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The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.
1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
This book constitutes the refereed proceedings of the 12th International Conference on Machine Learning and Data Mining in Pattern Recognition, MLDM 2016, held in New York, NY, USA in July 2016. The 58 regular papers presented in this book were carefully reviewed and selected from 169 submissions. The topics range from theoretical topics for classification, clustering, association rule and pattern mining to specific data mining methods for the different multimedia data types such as image mining, text mining, video mining and Web mining.
This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both classroom exercises as well as self-guided exploration and learning. As such, the book is ideal for self-learning and also as the basis of a semester-long course for undergraduate and graduate students in molecular biology, bioengineering, genome sciences, or systems biology.
This three-volume set LNAI 8724, 8725 and 8726 constitutes the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases: ECML PKDD 2014, held in Nancy, France, in September 2014. The 115 revised research papers presented together with 13 demo track papers, 10 nectar track papers, 8 PhD track papers, and 9 invited talks were carefully reviewed and selected from 550 submissions. The papers cover the latest high-quality interdisciplinary research results in all areas related to machine learning and knowledge discovery in databases.
Teaches the use of modern computational methods for the analysis of biomedical systems using case studies and accompanying software.
This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.
Handbook of HydroInformatics Volume III: Water Data Management Best Practices presents the latest and most updated data processing techniques that are fundamental to Water Science and Engineering disciplines. These include a wide range of the new methods that are used in hydro-modeling such as Atmospheric Teleconnection Pattern, CONUS-Scale Hydrologic Modeling, Copula Function, Decision Support System, Downscaling Methods, Dynamic System Modeling, Economic Impacts and Models, Geostatistics and Geospatial Frameworks, Hydrologic Similarity Indices, Hydropower/Renewable Energy Models, Sediment Transport Dynamics Advanced Models, Social Data Mining, and Wavelet Transforms. This volume is an example of true interdisciplinary work. The audience includes postgraduates and above interested in Water Science, Geotechnical Engineering, Soil Science, Civil Engineering, Chemical Engineering, Computer Engineering, Engineering, Applied Science, Earth and Geoscience, Atmospheric Science, Geography, Environment Science, Natural Resources, Mathematical Science, and Social Sciences. It is a fully comprehensive handbook which provides all the information needed related to the best practices for managing water data. - Contributions from global experts in the fields of data management research, climate change and resilience, insufficient data problem, etc. - Thorough applied examples and case studies in each chapter, providing the reader with real world scenarios for comparison. - Includes a wide range of new methods that are used in hydro-modeling, with step-by-step guides on how to use them.
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.