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This edited volume provides insights into and tools for the modeling, analysis, optimization, and control of large-scale networks in the life sciences and in engineering. Large-scale systems are often the result of networked interactions between a large number of subsystems, and their analysis and control are becoming increasingly important. The chapters of this book present the basic concepts and theoretical foundations of network theory and discuss its applications in different scientific areas such as biochemical reactions, chemical production processes, systems biology, electrical circuits, and mobile agents. The aim is to identify common concepts, to understand the underlying mathematical ideas, and to inspire discussions across the borders of the various disciplines. The book originates from the interdisciplinary summer school “Large Scale Networks in Engineering and Life Sciences” hosted by the International Max Planck Research School Magdeburg, September 26-30, 2011, and will therefore be of interest to mathematicians, engineers, physicists, biologists, chemists, and anyone involved in the network sciences. In particular, due to their introductory nature the chapters can serve individually or as a whole as the basis of graduate courses and seminars, future summer schools, or as reference material for practitioners in the network sciences.
This book is the culmination of three years of research effort on a multidisciplinary project in which physicists, mathematicians, computer scientists and social scientists worked together to arrive at a unifying picture of complex networks. The contributed chapters form a reference for the various problems in data analysis visualization and modeling of complex networks.
The nature of biomedical research has been evolving in recent years. Technological advances that make it easier to study the vast complexity of biological systems have led to the initiation of projects with a larger scale and scope. In many cases, these large-scale analyses may be the most efficient and effective way to extract functional information from complex biological systems. Large-Scale Biomedical Science: Exploring Strategies for Research looks at the role of these new large-scale projects in the biomedical sciences. Though written by the National Academies' Cancer Policy Board, this book addresses implications of large-scale science extending far beyond cancer research. It also identifies obstacles to the implementation of these projects, and makes recommendations to improve the process. The ultimate goal of biomedical research is to advance knowledge and provide useful innovations to society. Determining the best and most efficient method for accomplishing that goal, however, is a continuing and evolving challenge. The recommendations presented in Large-Scale Biomedical Science are intended to facilitate a more open, inclusive, and accountable approach to large-scale biomedical research, which in turn will maximize progress in understanding and controlling human disease.
A large-scale system is composed of several interconnected subsystems. For such a system it is often desired to have some form of decentralization in the control structure, since it is typically not realistic to assume that all output measurements can be transmitted to every local control station. Problems of this kind can appear in electric power systems, communication networks, large space structures, robotic systems, economic systems, and traffic networks, to name only a few. Typical large-scale control systems have several local control stations which observe only local outputs and control only local inputs. All controllers are involved, however, in the control operation of the overall system. The focus of this book is on the efficient control of interconnected systems, and it presents systems analysis and controller synthesis techniques using a variety of methods. A systematic study of multi-input, multi-output systems is carried out and illustrative examples are given to clarify the ideas.
Workshop Proceedings, Indian Statistical Institute, Kolkata December 19-20, 2015
This open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production.
An introduction to the quantitative modeling of biological processes, presenting modeling approaches, methodology, practical algorithms, software tools, and examples of current research. The quantitative modeling of biological processes promises to expand biological research from a science of observation and discovery to one of rigorous prediction and quantitative analysis. The rapidly growing field of quantitative biology seeks to use biology's emerging technological and computational capabilities to model biological processes. This textbook offers an introduction to the theory, methods, and tools of quantitative biology. The book first introduces the foundations of biological modeling, focusing on some of the most widely used formalisms. It then presents essential methodology for model-guided analyses of biological data, covering such methods as network reconstruction, uncertainty quantification, and experimental design; practical algorithms and software packages for modeling biological systems; and specific examples of current quantitative biology research and related specialized methods. Most chapters offer problems, progressing from simple to complex, that test the reader's mastery of such key techniques as deterministic and stochastic simulations and data analysis. Many chapters include snippets of code that can be used to recreate analyses and generate figures related to the text. Examples are presented in the three popular computing languages: Matlab, R, and Python. A variety of online resources supplement the the text. The editors are long-time organizers of the Annual q-bio Summer School, which was founded in 2007. Through the school, the editors have helped to train more than 400 visiting students in Los Alamos, NM, Santa Fe, NM, San Diego, CA, Albuquerque, NM, and Fort Collins, CO. This book is inspired by the school's curricula, and most of the contributors have participated in the school as students, lecturers, or both. Contributors John H. Abel, Roberto Bertolusso, Daniela Besozzi, Michael L. Blinov, Clive G. Bowsher, Fiona A. Chandra, Paolo Cazzaniga, Bryan C. Daniels, Bernie J. Daigle, Jr., Maciej Dobrzynski, Jonathan P. Doye, Brian Drawert, Sean Fancer, Gareth W. Fearnley, Dirk Fey, Zachary Fox, Ramon Grima, Andreas Hellander, Stefan Hellander, David Hofmann, Damian Hernandez, William S. Hlavacek, Jianjun Huang, Tomasz Jetka, Dongya Jia, Mohit Kumar Jolly, Boris N. Kholodenko, Markek Kimmel, Michał Komorowski, Ganhui Lan, Heeseob Lee, Herbert Levine, Leslie M Loew, Jason G. Lomnitz, Ard A. Louis, Grant Lythe, Carmen Molina-París, Ion I. Moraru, Andrew Mugler, Brian Munsky, Joe Natale, Ilya Nemenman, Karol Nienałtowski, Marco S. Nobile, Maria Nowicka, Sarah Olson, Alan S. Perelson, Linda R. Petzold, Sreenivasan Ponnambalam, Arya Pourzanjani, Ruy M. Ribeiro, William Raymond, William Raymond, Herbert M. Sauro, Michael A. Savageau, Abhyudai Singh, James C. Schaff, Boris M. Slepchenko, Thomas R. Sokolowski, Petr Šulc, Andrea Tangherloni, Pieter Rein ten Wolde, Philipp Thomas, Karen Tkach Tuzman, Lev S. Tsimring, Dan Vasilescu, Margaritis Voliotis, Lisa Weber
This book constitutes the thoroughly refereed post-conference proceedings of 12 workshops held at the 21st International Conference on Parallel and Distributed Computing, Euro-Par 2015, in Vienna, Austria, in August 2015. The 67 revised full papers presented were carefully reviewed and selected from 121 submissions. The volume includes papers from the following workshops: BigDataCloud: 4th Workshop on Big Data Management in Clouds - Euro-EDUPAR: First European Workshop on Parallel and Distributed Computing Education for Undergraduate Students - Hetero Par: 13th International Workshop on Algorithms, Models and Tools for Parallel Computing on Heterogeneous Platforms - LSDVE: Third Workshop on Large Scale Distributed Virtual Environments - OMHI: 4th International Workshop on On-chip Memory Hierarchies and Interconnects - PADAPS: Third Workshop on Parallel and Distributed Agent-Based Simulations - PELGA: Workshop on Performance Engineering for Large-Scale Graph Analytics - REPPAR: Second International Workshop on Reproducibility in Parallel Computing - Resilience: 8th Workshop on Resiliency in High Performance Computing in Clusters, Clouds, and Grids - ROME: Third Workshop on Runtime and Operating Systems for the Many Core Era - UCHPC: 8th Workshop on UnConventional High Performance Computing - and VHPC: 10th Workshop on Virtualization in High-Performance Cloud Computing.
This thesis considers the linear-quadratic optimal control problem for differential-algebraic systems. In this first part, a complete theoretical analysis of this problem is presented. The basis is a new differential-algebraic version of the Kalman-Yakubovich-Popov (KYP) lemma. One focus is the analysis of the solution structure of the associated descriptor KYP inequality. In particular, rank-minimizing, stabilizing, and extremal solutions are characterized which gives a deep insight into the structure of the problem. Further contributions include new relations of the descriptor KYP inequality to structured matrix pencils, conditions for the existence of nonpositive solutions, and the application of the new theory to the characterization of dissipative systems and the factorization of rational matrix-valued functions. The second part of this thesis focuses on robustness questions, i.e., the influence of perturbations on system properties like dissipativity and stability is discussed. Characterizations for the distance of a dissipative systems to the set of non-dissipative systems are given which lead to a numerical method for computing this distance. Furthermore, the problem of computing the H-infinity-norm of a large-scale differential-algebraic system is considered. Two approaches for this computation are introduced and compared to each other.