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This report presents a cost analysis of Lactic Acid production from glucose syrup using a low pH fermentation process The process examined is similar to Cargill process. In this process, a 70 wt% glucose-water syrup is used as raw material and an 88 wt% lactic acid solution in water is generated as final product. This report was developed based essentially on the following reference(s): (1) US Patent 20060094093, issued to Cargill in 2006 (2) US Patent 7736514, issued to BASF in 2010 Keywords: Dextrose, 2-Hydroxypropanoic Acid, Anaerobic Fermentation, Cell Recycle, Acid Tolerant Bacteria
This report presents a cost analysis of Lactic Acid production from glucose syrup using a low pH fermentation process. The process examined is similar to Cargill process. In this process, a 70 wt% glucose-water syrup is used as raw material and an 88 wt% lactic acid solution in water is generated as final product. This report was developed based essentially on the following reference(s): (1) US Patent 20060094093, issued to Cargill in 2006 (2) US Patent 7736514, issued to BASF in 2010 Keywords: Dextrose, 2-Hydroxypropanoic Acid, Anaerobic Fermentation, Cell Recycle, Acid Tolerant Bacteria
Modern analytical biotechnology is focused on the use of a set of enabling platform technologies that provide contemporary, state-of-the-art tools for genomics, proteomics, metabolomics, drug discovery, screening, and analysis of natural product molecules. Thus, analytical biotechnology covers all areas of bioanalysis from biochips and nano-chemistry to biology and high throughput screening. Moreover, it aims to apply advanced automation and micro fabrica tion technology to the development of robotic and fluidic devices as well as integrated systems. This book focuses on enhancement technology development by promoting cross-disciplinary approaches directed toward solving key problems in biology and medicine. The scope thus brings under one umbrella many different techniques in allied areas. The purpose is to support and teach the fundamental principles and practical uses of major instrumental techniques. Major platforms are the use of immobilized molecules in biotechnology and bioanalysis, im munological techniques, immunological strip tests, fluorescence detection and confocal techniques, optical and electrochemical biosensors, biochips, micro dotting, novel transducers such as nano clusters, atomic force microscopy based techniques and analysis in complex media such as fermentation broth, plasma and serum. Techniques related to HPLC, capillary electrophoresis, gel electrophoresis, and mass spectrometry have not been included in this book but will be covered by further publications. Fundamentals in analytical biotechnology include basic and practical aspects of characterizing and analyzing DNA, proteins, and small metabolites.
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This report presents a cost analysis of Lactic Acid production from glucose syrup using a fermentation process. The process examined is similar to Corbion process. In this process, a 70 wt% glucose-water syrup is used as raw material. The fermentation broth is acidified in order to recover Lactic Acid and the product purification is realized by the use of a solvent. An 88 wt% Lactic Acid solution in water is generated as final product. This report examines one-time costs associated with the construction of a United States-based plant and the continuing costs associated with the daily operation of such a plant. More specifically, it discusses: * Capital Investment, broken down by: - Total fixed capital required, divided in production unit (ISBL); infrastructure (OSBL) and contingency - Alternative perspective on the total fixed capital, divided in direct costs, indirect costs and contingency - Working capital and costs incurred during industrial plant commissioning and start-up * Production cost, broken down by: - Manufacturing variable costs (raw materials, utilities) - Manufacturing fixed costs (maintenance costs, operating charges, plant overhead, local taxes and insurance) - Depreciation and corporate overhead costs * Raw materials consumption, products generation and labor requirements * Process block flow diagram and description of industrial site installations (production unit and infrastructure) This report was developed based essentially on the following reference(s): (1) US Patent 7867736, issued to Purac (now Corbion) in 2011; (2) US Patent 6747173, issued to Purac (now Corbion) in 2004 Keywords: Dextrose, 2-Hydroxypropanoic Acid, Anaerobic Fermentation, Calcium Carbonate, Sulfuric Acid
This report presents a cost analysis of Lactic Acid production from glucose syrup using a fermentation process The process examined is similar to Cargill process. In this process, a 70 wt% glucose-water syrup is used as raw material. Lactic Acid recovery from the fermentation broth is realized by trialkylamine solvent extraction in the presence of carbon dioxide. The final product is Food Grade Lactic Acid solution containing 88 wt% of Lactic Acid. This report was developed based essentially on the following reference(s): (1) US Patent 6472559, issued to Cargill in 2002 (2) "Hydrocarboxylic Acids", Kirk-Othmer Encyclopedia of Chemical Technology, 5th edition Keywords: Dextrose, 2-Hydroxypropanoic Acid, Anaerobic Fermentation, Trialkyl Amine, Sodium Carbonate
This report presents a cost analysis of Lactic Acid production from glucose syrup using a speculative, continuous, low pH, fermentation process. In this process, a 70 wt% glucose-water syrup is used as raw material. Lactic Acid is recovered from the fermentation broth through microfiltration and nanofiltration steps. An 80 wt% Technical Grade Lactic Acid, with 95 wt% purity is generated as final product. This report was developed based essentially on the following reference(s): (1) Pal, P., et al., “Process Intensification in Lactic Acid Production: A Review of Membrane Based Processes” (2) Kwon, S., et al., “High-Rate Continuous Production of Lactic Acid by Lactobacillus rhamnosus in a Two-Stage Membrane Cell-Recycle Bioreactor” Keywords: Dextrose, 2-Hydroxypropanoic Acid, Anaerobic Fermentation, Cell Recycle
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