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Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.
An exploration of how states address the often conflicting challenges of development, order, and inclusion.
Reconnecting Reading and Writing explores the ways in which reading can and should have a strong role in the teaching of writing in college. Reconnecting Reading and Writing draws on broad perspectives from history and international work to show how and why reading should be reunited with writing in college and high school classrooms. It presents an overview of relevant research on reading and how it can best be used to support and enhance writing instruction.
The first systematic study of the practice of royal self-coronations from late antiquity to the present.
Written and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of tuberculosis of the central nervous system, with emphasis on clinical, diagnostics, and therapeutic features. Tuberculosis, one of the most lethal diseases in human history, still poses a serious threat in the world together with economic and social problems, although a great progress in the fight against this infectious disease in the last century. It covers the full range of tuberculosis of central nervous system and the chapters are organized into six sections: (1) the cranial; (2) the spinal; and (3) the peripheral portions of the nervous system; followed by (4) a section on the laboratory studies in tuberculosis; (5) a section on medical and surgical therapy; and (6) further insights into tuberculosis. This comprehensive reference book will be an ideal source for neurosurgeons, neurologists and specialists upon infectious diseases seeking both basic and more sophisticated information and surgical procedures relating to the complications associated with tuberculosis involving the spine, brain and peripheral nerves.
Increasingly, international governmental networks and organisations make it necessary to master the legal principles of other jurisdictions. Since the advent of international criminal tribunals this need has fully reached criminal law. A large part of their work is based on comparative research. The legal systems which contribute most to this systemic discussion are common law and civil law, sometimes called continental law. So far this dialogue appears to have been dominated by the former. While there are many reasons for this, one stands out very clearly: Language. English has become the lingua franca of international legal research. The present book addresses this issue. Thomas Vormbaum is one of the foremost German legal historians and the book's original has become a cornerstone of research into the history of German criminal law beyond doctrinal expositions; it allows a look at the system’s genesis, its ideological, political and cultural roots. In the field of comparative research, it is of the utmost importance to have an understanding of the law’s provenance, in other words its historical DNA.
Field epidemiology involves the application of epidemiologic methods to unexpected health problems when a rapid on-site investigation is necessary for timely intervention. Based on decades of experience in both infectious and noninfectious diseases at the Centers for Disease Control andPrevention, this book describes in simple and practical terms the distinct approach, tasks, and actions needed for successful field investigations. Guidance is given on such issues as how to perform surveillance, manage and execute field investigations, collect and analyze data, perform surveys,adapt a personal computer for field use, and communicate the findings. Specific advice is also given on such subjects as dealing with the media; investigations in health care, day care, and international settings; and the legal aspects of field studies. An entire chapter covers the propercollection, handling, and testing of infectious and noninfectious agents in the field. In the Second Edition, four new chapters cover many unique aspects of field studies in the workplace, after natural disasters, in preparation for and response to possible bioterrorist attacks, and by state andlocal health departments. Finally, an appendix describes how to investigate a common source food-borne epidemic. This text gives public health professionals and students a practical and complete refernece to use in virtually any field investigation setting.
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.