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Genistein is a naturally occurring isoflavone that interacts with estrogen receptors & multiple other molecular targets. Human exposure to Genistein is through consumption of soy products, including soy-based infant formula & dietary supplements. A series of short-term studies with Genistein was conducted with two goals: to obtain data necessary to establish dose levels for subsequent multi-generation reproductive & chronic toxicity studies; & to evaluate the effects of Genistein on endpoints outside the reproductive tract. This report focuses on the reproductive & toxicology endpoints. Data obtained in separate evaluations of behavioral, neuroanatomical, neurochemical, & immunological endpoints are also discussed. Illustrations.
Phenolphthalein (PH) was commonly used as a laxative for most of the 20th cent. The use of PH in laxatives has decreased since 1997 when the FDA proposed to withdraw its classification as an OTC drug. PH has been previously evaluated in carcinogenecity studies in 1996. The major route of human exposure to PH is via ingestion, dermal contact, & inhalation of contaminated air originating from process units manufacturing the compound. In this study, the carcinogenic effects of PH were studied in the haploinsufficient p16Ink4a/p19Arf mouse model as an ongoing goal to seek model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic info. relative to understanding an agent¿s model of action. Illustrations.
Includes subject area sections that describe all pertinent census data products available, i.e. "Business--trade and services", "Geography", "Transportation," etc.