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Loewen examines how the Mennonites' social structure and life goals accommodated societal changes and tells of three generations for whom the farm family was the primary social unit. The group's strategies of cultural continuity dictated that they adapt sensitively and carefully to the market economy and the outside world. Photos. Maps.
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
During the half-millennium from the eleventh through the sixth centuries BC, the power and the glory of the imperial pharaohs of the New Kingdom crumbled in the face of internal crises and external pressures, ultimately reversed by invaders from Nubia and consolidated by natives of the Nile Delta following a series of Assyrian invasions. Much of this era remains obscure, with little consensus among Egyptologists. Against this background, Aidan Dodson reconsiders the evidence and proposes a number of new solutions to the problems of the period. He also considers the era's art, architecture, and archaeology, including the royal tombs of Tanis, one of which yielded the intact burials of no fewer than five pharaohs. Afterglow of Empire is extensively illustrated with images of this material, much of which is little known to non-specialists. By the author of the bestselling Amarna Sunset and Poisoned Legacy.