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Isozymes, IV: Genetics and Evolution contains manuscripts presented at the Third International Conference on isozymes convened in April 1974 at Yale University. Separating 58 manuscripts into chapters, this book begins by elucidating the usefulness of isozymes as effective markers in studies of various aspects of genetics and evolution. Specific discussions are given to isozymes in evolutionary systematics and isozyme polymorphism maintenance mechanisms viewed from the standpoint of population genetics. This book explains multiple allelism and isozyme diversity in human populations. It also addresses the usefulness of isozyme variants as markers of population movement in man and plant population genetics.
Isoenzymes in Biology and Medicine attempts to give an account of the study of isoenzymes in relation to humans, animals, insects, higher plants, fungi, protozoa, algae, and bacteria. This book discusses the chemical structure, physiological aspects, metabolic role, and function of isoenzyme observations in genetic, ontogenic, and phylogenic studies. A detailed account of the use of isoenzyme in the diagnosis and pathogenesis of disease and control of therapy is also provided. This text likewise considers the isoenzymes of the oxidoreductases, transferases, and hydrolases, including its relation to clinical medicine. This publication is intended for biochemists, biologists, clinical biochemists and physicians.
Isozymes, III: Developmental Biology contains manuscripts presented at the Third International Conference on isozymes convened in April 1974 at Yale University. Separating 61 manuscripts into chapters, this book begins by discussing the areas of ""isozymology"" that appear particularly promising for further developmental analysis. This text also looks into the role of isozymes as genetic markers in early mammalian development, as well as the mechanisms of intracellular enzyme localization. Significant topics on specific isozymes are given separately in other chapters.
Isozymes, II: Physiological Function contains manuscripts presented at the Third International Conference on isozymes convened in April 1974 at Yale University. Separating 53 manuscripts into chapters, this book first discusses the medical uses of isozymes. It then describes the various dehydrogenase isozymes mechanisms of action and biological functions. Other general topics explored are the roles of isozymes in adaptation to varying temperatures and their use in the study of mitochondria. Significant topics on specific isozymes are given separately in other chapters.
Isoenzymes were 'discovered' 20 years ago and were at first regarded as interesting but rare occurrences. Since then a wealth of information on enzyme heterogeneity has accrued and it now seems likely that at least half of all enzymes exist as isoenzymes. This is important in many areas of biological and medical science. Thus isoenzyme studies have provided the main experimental substance for the neutral drift controversy in genetics and evolution; they have greatly extended our understanding of metabolic regulation not only in animals but also in bacteria and plants; their existence has made available a multitude of highly sensitive markers for the study of differentiation and development, as well as providing indices of aberrant gene expression in carcinogenesis and other pathological processes. Iso enzymes are also being used increasingly in diagnostic clinical bio chemistry. It is surprising that this phenomenon which affects such a high pro portion of enzymes and is clearly important in biochemistry should receive such scant attention in the standard textbooks of that subject, the formal treatment of isoenzymology in these rarely exceeding one or two pages. This may be because the 'pure biochemist' has tended to regard variation in enzyme properties between tissues more as an unwanted complication than as a potential source of insight into diversity of biological function.