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In August 1956 a young shepherd, his wife, two-year-old daughter and ten-day-old son sat huddled in a small boat on Loch Monar in Ross-shire as a storm raged around them. They were bound for a tiny, remote cottage at the western end of the loch which was to be their home for the next four years. Isolation Shepherd is the moving story of those years. Set against the awesome splendour of some of Scotland's most spectacular scenery, Iain R. Thomson's classic book provides a sensitive, richly detailed account of the shepherd's life through the seasons and recreates the events that shaped the family's life in Glen Strathfarrar before the area was flooded as part of a huge hydro-electric project.
Sequencing of the model plant genomes such as those of A. thaliana and rice has revolutionized our understanding of plant biology but it has yet to translate into the improvement of major crop species such as maize, wheat, or barley. Moreover, the comparative genomic studies in cereals that have been performed in the past decade have revealed the limits of conservation between rice and the other cereal genomes. This has necessitated the development of genomic resources and programs for maize, sorghum, wheat, and barley to serve as the foundation for future genome sequencing and the acceleration of genomic based improvement of these critically important crops. Cereals constitute over 50% of total crop production worldwide (http://www.fao.org/) and cereal seeds are one of the most important renewable resources for food, feed, and industrial raw materials. Crop species of the Triticeae tribe that comprise wheat, barley, and rye are essential components of human and domestic animal nutrition. With 17% of all crop area, wheat is the staple food for 40% of the world’s population, while barley ranks fifth in the world production. Their domestication in the Fertile Crescent 10,000 years ago ushered in the beginning of agriculture and signified an important breakthrough in the advancement of civilization. Rye is second after wheat among grains most commonly used in the production of bread and is also very important for mixed animal feeds. It can be cultivated in poor soils and climates that are generally not suitable for other cereals. Extensive genetics and cytogenetics studies performed in the Triticeae species over the last 50 years have led to the characterization of their chromosomal composition and origins and have supported intensive work to create new genetic resources. Cytogenetic studies in wheat have allowed the identification and characterization of the different homoeologous genomes and have demonstrated the utility of studying wheat genome evolution as a model for the analysis of polyploidization, a major force in the evolution of the eukaryotic genomes. Barley with its diploid genome shows high collinearity with the other Triticeae genomes and therefore serves as a good template for supporting genomic analyses in the wheat and rye genomes. The knowledge gained from genetic studies in the Triticeae has also been used to produce Triticale, the first human made hybrid crop that results from a cross between wheat and rye and combines the nutrition quality and productivity of wheat with the ruggedness of rye. Despite the economic importance of the Triticeae species and the need for accelerated crop improvement based on genomics studies, the size (1.7 Gb for the bread wheat genome, i.e., 5x the human genome and 40 times the rice genome), high repeat content (>80%), and complexity (polyploidy in wheat) of their genomes often have been considered too challenging for efficient molecular analysis and genetic improvement in these species. Consequently, Triticeae genomics has lagged behind the genomic advances of other cereal crops for many years. Recently, however, the situation has changed dramatically and robust genomic programs can be established in the Triticeae as a result of the convergence of several technology developments that have led to new, more efficient scientific capabilities and resources such as whole-genome and chromosome-specific BAC libraries, extensive EST collections, transformation systems, wild germplasm and mutant collections, as well as DNA chips. Currently, the Triticeae genomics "toolbox" is comprised of: - 9 publicly available BAC libraries from diploid (5), tetraploid (1) and hexaploid (3) wheat; 3 publicly available BAC libraries from barley and one BAC library from rye; - 3 wheat chromosome specific BAC libraries; - DNA chips including commercially available first generation chips from AFFYMETRIX containing 55’000 wheat and 22,000 barley genes; - A large number of wheat and barley genetic maps that are saturated by a significant number of markers; - The largest plant EST collection with 870’000 wheat ESTs, 440’000 barley ESTs and about 10’000 rye ESTs; - Established protocols for stable transformation by biolistic and agrobacterium as well as a transient expression system using VIGS in wheat and barley; and - Large collections of well characterized cultivated and wild genetic resources. International consortia, such as the International Triticeae Mapping Initiative (ITMI), have advanced synergies in the Triticeae genetics community in the development of additional mapping populations and markers that have led to a dramatic improvement in the resolution of the genetic maps and the amount of molecular markers in the three species resulting in the accelerated utilization of molecular markers in selection programs. Together, with the development of the genomic resources, the isolation of the first genes of agronomic interest by map-based cloning has been enabled and has proven the feasibility of forging the link between genotype and phenotype in the Triticeae species. Moreover, the first analyses of BAC sequences from wheat and barley have allowed preliminary characterizations of their genome organization and composition as well as the first inter- and intra-specific comparative genomic studies. These later have revealed important evolutionary mechanisms (e.g. unequal crossing over, illegitimate recombination) that have shaped the wheat and barley genomes during their evolution. These breakthroughs have demonstrated the feasibility of developing efficient genomic studies in the Triticeae and have led to the recent establishment of the International Wheat Genome Sequencing Consortium (IWGSC) (http//:www.wheatgenome.org) and the International Barley Sequencing Consortium (www.isbc.org) that aim to sequence, respectively, the hexaploid wheat and barley genomes to accelerate gene discovery and crop improvement in the next decade. Large projects aiming at the establishment of the physical maps as well as a better characterization of their composition and organization through large scale random sequencing projects have been initiated already. Concurrently, a number of projects have been launched to develop high throughput functional genomics in wheat and barley. Transcriptomics, proteomics, and metabolomics analyses of traits of agronomic importance, such as quality, disease resistance, drought, and salt tolerance, are underway in both species. Combined with the development of physical maps, efficient gene isolation will be enabled and improved sequencing technologies and reduced sequencing costs will permit ultimately genome sequencing and access to the entire wheat and barley gene regulatory elements repertoire. Because rye is closely related to wheat and barley in Triticeae evolution, the latest developments in wheat and barley genomics will be of great use for developing rye genomics and for providing tools for rye improvement. Finally, a new model for temperate grasses has emerged in the past year with the development of the genetics and genomics (including a 8x whole genome shotgun sequencing project) of Brachypodium, a member of the Poeae family that is more closely related to the Triticeae than rice and can provide valuable information for supporting Triticeae genomics in the near future. These recent breakthroughs have yet to be reviewed in a single source of literature and current handbooks on wheat, barley, or rye are dedicated mainly to progress in genetics. In "Genetics and Genomics of the Triticeae", we will aim to comprehensively review the recent progress in the development of structural and functional genomics tools in the Triticeae species and review the understanding of wheat, barley, and rye biology that has resulted from these new resources as well as to illuminate how this new found knowledge can be applied for the improvement of these essential species. The book will be the seventh volume in the ambitious series of books, Plant Genetics and Genomics (Richard A. Jorgensen, series editor) that will attempt to bring the field up-to-date on the genetics and genomics of important crop plants and genetic models. It is our hope that the publication will be a useful and timely tool for researchers and students alike working with the Triticeae.
Presents a survey of what is known about sexual disorders and their treatment. It covers all the therapeutic approaches to sexual dysfunction: psychoanalytic, behavioural, Masters and Johnson's, Helen Kaplan's, and the holistic.
'Coffin roads' along which bodies were carried for burial are a marked feature of the landscape of the Scottish Highlands and islands – many are now popular walking and cycling routes. This book journeys along eight coffin roads to discover and explore the distinctive traditions, beliefs and practices around dying, death and mourning in the communities which created and used them. The result is a fascinating snapshot into place and culture. After more than a century when death was very much a taboo subject, this book argues that aspects of the distinctive West Highland and Hebridean way of death and approach to dying and mourning may have something helpful and important to offer to us today. Routes covered in this book are: The Kilmartin Valley – the archetypal coffin road in this ritual landscape of the dead. The Street of the Dead on Iona – perhaps the best known coffin road in Scotland. Kilearnadil Graveyard, Jura – a perfect example of a Hebridean graveyard. The coffin road through Morvern to Keil Church, Lochaline - among the best defined and most evocative coffin roads today. The Green Isle, Loch Shiel, Ardnamurchan - the oldest continuously used burial place anywhere in Europe. The coffin road on Eigg – with its distinctive 'piper's cairn' where the coffin of Donald MacQuarrie, the 'Great Piper of Eigg', was rested. The coffin road from Traigh Losgaintir to Loch Stocinis on Harris - popular with walkers and taken as the title for a best-selling thriller by Peter May. The coffin road on Barra – A detailed study of burial practices on Barra in the early 1950s provides a fascinating record of Hebridean attitudes to dying, death and mourning.
Through the ages, the book of Ecclesiastes (Qoheleth) has elicited a wide variety of interpretations. Its status as wisdom literature is secure, but its meaning for the religion of the Hebrew Bible and its heirs has been a matter of much debate. The debate has swung from claiming orthodoxy for the book to arguing that the message intended by its author is heterodox, in its entirety. There are a number of passages in the book that present difficulties for any comprehensive approach to the work. Martin Shields here fully acknowledges the heterodox nature of Qoheleth’s words but offers an orthodox reading of the book as a whole through the eyes of the author of the epilogue. After a survey of attitudes regarding wisdom in the Hebrew Bible itself, which serves as an orientation to the monograph as a whole, Shields provides a detailed study of the epilogue (Qoh 12:9–14), which he believes is the key to the reading of the remainder of the book. He then addresses various problematic texts in the book in light of this perspective, arguing that the book could originally have functioned as a warning to students against joining a wisdom movement that existed at the time of the book’s composition. Qoheleth is presented as a true adherent of this movement, and the divergence of his words from the theism presented in the rest of the Hebrew Bible becomes the basis of the epilogue’s critique. Finally, Shields proposes a historical context in which just this scenario may have arisen, showing that the desire of the writer of the epilogue is to correct a wayward wisdom tradition.
Straight out of today’s hospitals and labs–and tomorrow’s headlines–comes a frightening, scalpel-sharp thriller from medical insider Joshua Spanogle. In an astounding debut, Spanogle takes us on an all-too-real race against time…as a young doctor enters the dark side of scientific research, desperate to stop a terrifying epidemic before it is too late…. In Baltimore’s St. Raphael’s Hospital, three newly admitted patients are among society’s most helpless citizens: female residents of Baltimore’s group homes for the mentally impaired, their bodies racked by a virus the likes of which no one at St. Raphael’s has ever seen. Dr. Nathaniel McCormick is one of the first on the scene. A young investigator from the Centers for Disease Control, Nate is paid to explore the bizarre, the exotic, and the baffling–from superviruses to bioterrorism. But as soon as Nate begins to investigate the lives and habits of the victims, he knows something is terribly wrong. Using all his skills as a medical detective, Nate soon zeroes in on the “vector”–the one person who had sexual contact with the first victims. And when that suspect is found murdered, Nate fears that the disease he’s chasing may not be an act of nature, but of man. With his brash style angering his superiors and fellow investigators alike, Nate turns to an old colleague and former lover, Dr. Brooke Michaels, for help. Together the two investigators follow a twisting trail of clues to a discovery that is at once groundbreaking and unspeakable. And as a circle of treachery tightens around him, Nate is about to confront the most chilling revelation of all–and a past Nate himself has been trying to escape. At once a taut medical thriller and a riveting psychological portrait of a young doctor on the edge, Isolation Ward is a tale of runaway tension–with a brilliant “what-if” premise that is harrowing…heartbreaking…and impossible to wrench from your imagination.
A teen girl on a quest to find her long-lost mother finds herself on a journey of self-discovery in Kristy Dallas Alley's moving YA debut, The Ballad of Ami Miles. Raised in isolation at Heavenly Shepherd, her family’s trailer-dealership-turned-survival compound, Ami Miles knows that she was lucky to be born into a place of safety after the old world ended and the chaos began. But when her grandfather brings home a cold-eyed stranger, she realizes that her “destiny” as one of the few females capable of still bearing children isn’t something she’s ready to face. With the help of one of her aunts, she flees the only life she’s ever known and sets off on a quest to find her long-lost mother (and hopefully a mate of her own choosing). But as she journeys, Ami discovers many new things about the world...and about herself.
Harris' Developmental Neuropsychiatry provides updated information to the first edition which defined the field of developmental neuropsychiatry, and is the most recent comprehensive textbook in the field.