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Studies on the colon not only serve medical interest or clinical purposes, but are also a highly interesting subject of comparative physiology, from which we can learn much about the basic principles in physiology. Presented here are examples of research on colonic ion transport of each vertebrate group, including the classical models of epithelia, rat and rabbit, and also on the special and unique features in fish, amphibians, reptiles, birds, and selected mammals such as the guinea pig. Physiology and pathophysiology of ion transport in the human large intestine are as well covered as the use of colonic cell cultures as model systems for crypt cell properties.
Studies on the colon not only serve medical interest or clinical purposes, but are also a highly interesting subject of comparative physiology, from which we can learn much about the basic principles in physiology. Presented here are examples of research on colonic ion transport of each vertebrate group, including the classical models of epithelia, rat and rabbit, and also on the special and unique features in fish, amphibians, reptiles, birds, and selected mammals such as the guinea pig. Physiology and pathophysiology of ion transport in the human large intestine are as well covered as the use of colonic cell cultures as model systems for crypt cell properties.
After the pioneering studies by Ussing and co-workers, studies of epithelial Nael transport have come a long way. The first phase of the phenomenological description of the cell as a black box has been follow ed by studies of cellular mechanisms, the interplay of the different trans port components, and the mechanisms of regulation. A broad spectrum of methods has been applied to many epithelia in a variety of species. For the individual epithelia transport schemes have been proposed, and, at this point I think it is appropriate to take a pause and search for elements common to several epithelia. This aspect triggered the publica tion of this book, and in fact the various chapters emphasize that the funetional eomponents, expressed in the various epithelia, are not in finite in number, but they occur in epithelia which are separated in evolu tion by several hundred million years. The authors come both from the field of veterinary and human physiology as weIl as from biology. In my opinion, the close contacts and eollaborations between physiologists and biologists have been essential for the progress in this field. I wish to thank all authors for their con tributions, and I hope that the reader will appreciate this collection of up to date reviews on epithelia in nonvertebrates and vertebrates.
This is the fourth Falk Symposium devoted to the study of intestinal abso~ l 3 tion. As in the case of its predecessors - , I hope that the relaxed atmosphere will enable the participants from all comers of the world to exchange views, not only in this room, but also at less formal moments in the cellar, on the lake, or in the buses that transport us to different parts of the Schwarzwald. We are all eternally grateful to Dr Herbert Falk for undertaking to sponsor this meeting, and to him and his staff for the impeccable organisation which will permit us to work in such a pleasant environment. In the organisation of the programme, one or two innovations have been in troduced which are perhaps foreign to routine gastroenterological meetings. First, the average age in this room is rather lower than at most gatherings of this nature, which means that those who carry out the experiments will be responsible for their presentation; they are after all the ones who have made the relevant small observations which lead to the advancement of knowledge.
Fourth Conference of the European Society for Comparative Physiology and Biochemistry, Bielefeld, September 8-11, 1982
Many physiological processes are regulated by the movement of ions into and out of organs, tissues, and cells. During the past decade, a variety of new techniques and approaches have contributed to a deeper understanding of the myriad influences ions have on the function and structure of organisms. From respiration and excretion to neurological control and metabolic processing, ions and their regulation occupy a central role in physiology of fish as well as other organisms. - Comprehensive update of ionic regulation in fish - Focuses on wide variety of organ systems and the influence of ions on organ system function - Contributions from an international group
Vertebrate Endocrinology: Fundamentals and Biomedical Implications, Volume 2: Regulation of Water and Electrolytes provides information pertinent to vertebrate endocrine systems, which has significant contributions to basic biological and biomedical research. This book discusses the practical implications of the endocrinological studies. Organized into 13 chapters, this volume starts with an overview of the comprehensive aspects of endocrinology in mammalian and nonmammalian vertebrates, with emphasis on those systems that affect salt and water balance. This book then discusses the control of secretion as well as the function and biomedical implications of knowledge of secretion and function. Other chapters discuss several topics, including neurohypophysis, adrenal hormones, and pancreatic hormones. This text discusses as well the renin–angiotensin system. The final chapter deals with the changes that occur during vertebrate evolution in smaller peptide hormones, such as the neurohypophysial peptides and the angiotensins. Endocrinologists, biologists, graduate students, and researchers will find this book extremely useful.