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It can be seen that the insects are the still attracting most research and researchers. However, an increasing interest is emerging to study new invertebrate groups, especially those where the genome is known. Even though Drosophila has been and still is an excellent model for immune studies, it is now clear that there are great differences between immune responses in Drosophila and that of several other invertebrates, which indeed calls for more research on other invertebrates
Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.
The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo lecular contexts in which the mechanism was introduced.
Immunology of Annelids provides a state-of-the-art review of the biological and biochemical processes involved in defense reactions of annelids. The book covers phylogeny, taxonomy, and fundamental body structure to provide basic information essential to developing a full understanding of the defense system of an organism. Physiological aspects of the relationship between the immune systems and cells and their limitations are discussed in detail, and the role of cells in cellular defense, transplantation, and humoral defenses is explained. The importance of annelids and their defense reaction from the phylogenetic standpoint is examined in a chapter comparing vertebrate and invertebrate defense strategies. Immunology of Annelids is a practical reference for cell biologists, immunologists, evolutionary and developmental biologists, and other researchers who need insight into the development and hierarchy of immune reactions.
The biological bases of invertebrate immune responses have interested scientists for decades, from the first relevant observation by E. Metchnikoff in 1882, who discovered phagocytosis while studying starfish larvae. Invertebrate immunology first began to be appre ciated as an important field in the late 1960s and 1970s. However, in the following years there was much controversy regarding the question: do invertebrates offer insight into the origin of the sophisticated immune responses of the vertebrates? There are several reasons why progress in research on invertebrate immune competence has been painfully slow. One of the main impediments to the progress, as compared to the fast development of knowledge in the vertebrate systems, was the fact that most of the studies concentrated on "whole organism" assays, mainly on grafting tissues between allogeneic partners. Only in the last few years have more and more aspects of invertebrate immunity been investigated on the cellular, biochemical and molecular levels. These studies led to discoveries of novel defense reactions, new pathways of effector mechanisms which are elicited after recognition of "nonself', and complex, sometimes highly polymorphic genetic elements that control invertebrate immune reactions. The importance of invertebrate immunity for understanding "immunology" as a whole, despite the conflicting models and hypotheses, is now much more recognized than before. Although most of the 20 phyla belonging to the inver tebrates have different modes of life, body organizations, habitats occupied, and biochemical patterns, they show striking aspects of exceptional precision for discriminating between self and nonself.
A rapidly growing interdisciplinary field, disease ecology merges key ideas from ecology, medicine, genetics, immunology, and epidemiology to study how hosts and pathogens interact in populations, communities, and entire ecosystems. Bringing together contributions from leading international experts on the ecology of diseases among invertebrate species, this book provides a comprehensive assessment of the current state of the field. Beginning with an introductory overview of general principles and methodologies, the book continues with in-depth discussions of a range of critical issues concerning invertebrate disease epidemiology, molecular biology, vectors, and pathogens. Topics covered in detail include: Methods for studying the ecology of invertebrate diseases and pathogens Invertebrate pathogen ecology and the ecology of pathogen groups Applied ecology of invertebrate pathogens Leveraging the ecology of invertebrate pathogens in microbial control Prevention and management of infectious diseases of aquatic invertebrates Ecology of Invertebrate Diseases is a necessary and long overdue addition to the world literature on this vitally important subject. This volume belongs on the reference shelves of all those involved in the environmental sciences, genetics, microbiology, marine biology, immunology, epidemiology, fisheries and wildlife science, and related disciplines.
E. L. Cooper In Volume 23 we considered, in seven chapters, the basic armamentarium of the invertebrate immune system and its cells, as well as an analysis of antigens, setting the stage for the initiation of an immune response. We studied cell products, natural or induced, as revealed by nonspecific and specific responses following antigenic challenge such as the pro phenol oxidase system, the lytic responses, the Ig superfamily, and the place this family offers invertebrates and insect hemolymph proteins as candidates for membership. At this point, these various topics seemed to converge, almost to overlap, in some instances, presenting a challenge as to how to move from one subject to another. Chapter 1, in this volume offers the bridge to Volume 23 and its final Chapter 7. This Volume 24 contains contributions pertaining to cell activities and the environment. Chapters 1-4 refer specifically to interactions between cells and the integration of cell activities. The focus is on a functional immune system, with antigenic challenge as a subtopic. In Chapters 5-7, the environment is considered from several points of view and the main subtopic here is the result of the consequences of connections and missed signals. The internal and external environments are treated, revealing what may happen when normal immune responses are interfered with. All this is integrated by the consideration of the three great regulatory systems, the ever-present network that somehow acts as the monitor or control for all incoming and outgoing signals.
The nervous system is particularly fascinating for many biologists because it controls animal characteristics such as movement, behavior, and coordinated thinking. Invertebrate neurobiology has traditionally been studied in specific model organisms, whilst knowledge of the broad diversity of nervous system architecture and its evolution among metazoan animals has received less attention. This is the first major reference work in the field for 50 years, bringing together many leading evolutionary neurobiologists to review the most recent research on the structure of invertebrate nervous systems and provide a comprehensive and authoritative overview for a new generation of researchers. Presented in full colour throughout, Structure and Evolution of Invertebrate Nervous Systems synthesizes and illustrates the numerous new findings that have been made possible with light and electron microscopy. These include the recent introduction of new molecular and optical techniques such as immunohistochemical staining of neuron-specific antigens and fluorescence in-situ-hybridization, combined with visualization by confocal laser scanning microscopy. New approaches to analysing the structure of the nervous system are also included such as micro-computational tomography, cryo-soft X-ray tomography, and various 3-D visualization techniques. The book follows a systematic and phylogenetic structure, covering a broad range of taxa, interspersed with chapters focusing on selected topics in nervous system functioning which are presented as research highlights and perspectives. This comprehensive reference work will be an essential companion for graduate students and researchers alike in the fields of metazoan neurobiology, morphology, zoology, phylogeny and evolution.