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Intractable Focal Epilepsyis a definitive multi author reference work covering the most difficult to treat epilepsies. The natural history, pathology and treatment, both medical and surgical, of the conditions underlying intractable seizures are fully described and illustrated. Including contributions from North America, Europe and the Pacific Rim, the emphasis throughout is on clinical diagnosis and treatment both medical and surgical, and their respective outcomes. The text is enhanced by over 250 illustrations, and the clear modern design enables the reader to assimilate information quickly. In addition to clinical treatment, there is a section on the costs of persistent intractable focal epilepsy and the costs of surgical treatment. Drs Oxbury, Polkey and Duchowny have produced a book that will appeal to epileptologists, paediatric neurologists, and neurosurgeons. The books clinical strengths will make it an invaluable working tool. Definitive resource on difficult to treat epilepsies Covers manifestation, consequences and treatment Major section on surgical treatment of focal epilepsy Complete coverage of paediatric diagnosis and treatment Special "Case Reports" give practical case histories to illustrate clinical points International line up of contributors
This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. - Provides a comprehensive reference detailing animal models of epilepsy and seizure - Offers insights on the use of novel technologies that can be applied in experimental epilepsy research - Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques - Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders.*Provides a crucial update of recent advances in imaging techniques*Timely publication as subject of neuroimaging is a very "hot" area in both clinical epilepsy and basic neuroscience research*Editors are well-respected in this field
This work is the result of a recently held International Epilepsy Colloquium on the mesial temporal lobe epilepsies (MTLE) which covered all aspects of this specific group of syndromes (or constellations), from animal model to treatment strategies. Written by international experts from different fields, it aims to provide professionals from neuroscientists to clinical neurologists, neurosurgeons and neuropaedia-tricians dealing with mesial temporal lobe epilepsy, with a concise overview on the current body of knowledge and on emerging concepts and findings.
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”
Part of the Neurosurgery by Example series, this volume on functional neurosurgery presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, after care, and complication management of common and uncommon disorders. The cases explore the spectrum of clinical diversity and complexity within functional neurosurgery, including essential tremor, thalamotomy, parkinson's disease, epilepsy, dystonia, and more. Each chapter also contains 'pivot points' that illuminate changes required to manage patients in alternate or atypical situations, and pearls for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Functional Neurosurgery is appropriate for neurosurgeons who wish to learn more about a subspecialty, and those preparing for the American Board of Neurological Surgery oral examination.
Textbook of Epilepsy Surgery covers all of the latest advances in the surgical management of epilepsy. The book provides a better understanding of epileptogenic mechanisms in etiologically different types of epilepsy and explains neuronavigation systems. It discusses new neuroimaging techniques, new surgical strategies, and more aggressive surgical approaches in cases with catastrophic epilepsies. The contributors also analyze the improved statistics of surgical outcome in different epilepsy types. This definitive textbook is an invaluable reference for neurologists, neurosurgeons, epilepsy specialists, and those interested in epilepsy and its surgical treatment.