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When Richard Goldschmidt' coined the term "intersexuality" in 1915, he intended it to apply to normally dioecious species which exhibit some kind of mixture between male and female characters. However, as knowledge of the bewildering variability present in the sexual orga nization of members of the animal kingdom has increased, the original meaning of the word has changed. Today many authors define inter sexuality as "the presence of both male and female characteristics, or of intermediate sexual characteristics, in a single individual".2 This more extensive and widely accepted concept justifies the title of our book •. Among all the anatomical and physiological features of living organisms the reproductive system has a unique importance for the perpetuation of the species. Conversely, reproductive processes are of little or no account for the viability of the individual. Therefore, within the framework of general biology reproduction has all too often been looked at solely from the point of view of genetics. Lively discussions about genotypic versus phenotypic sex determination long dominated the sci entific literature on sexuality in animals; this one-sided emphasis has tended to obscure many important facets of an organism's ability to reproduce. Recent developments in current biological research have brought the classic problem of sex differentiation into focus again, and the rapid progress being made in comparative endocrinology has added a new di mension to the study of reproductive biology.
How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Müllerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.
The Pineal Gland of Vertebrates Including Man
The cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene opened a new era in research on sex determination. This book surveys current knowledge of sex chromosomes and sex determination in all vertebrate classes, relying on the restriction of genetic recombination in sex chromosomes as the unifying concept of this subject. The book's interdisciplinary approach integrates contributions from the fields of cytogenetics, molecular biology, developmental biology, and evolutionary genetics. A detailed treatment of the meiotic behavior of sex chromosomes is featured, and the entire text is supplemented by numerous schemes, drawings, and electron micrographs. The book will be valuable to general cytogeneticists, vertebrate zoologists, and veterinarian and medical practitioners interested in the foundations of sex determination and the current knowledge of sex chromosomes. It will also interest students in advanced undergraduate and graduate courses in these areas.
Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
First published in 1995, the book describes personal experiences of those who cross-dress and sex change, how they organise themselves socially - in both `outsider' and `respectable' communities. The contributors consider the dominant medical framework through which gender blending is so often seen and look at the treatment afforded gender blending in literature, the press and the recently emerged telephone sex lines. The book concludes with a discussion of the lively debates that have taken place concerning the politics of transgenderism in recent years, and examines its prominence in recent contributions to contemporary cultural theory and queer theory.