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This policy brief is based on the evidence on the mortality and morbidity during and post-TB disease and proposes the policy approach to address the needs of people with TB-assiciated disability. The policy brief builds on existing evidence in the areas of TB, TB-comorbidities, TB in vulberable populations, disability, and rehabilitation and it is aligned with the currently WHO recommended policies and guidances on these topics. moreover, the policy brief aims at informing and promoting strengthened collaborative actions between national TB programmes with other disease programmes and health systems functions, to deliver people-centres care to people with TB-assiciated impairments and disabilities during and after TB treatment. The policy brief is intended for use by the national TB programmes, TB care providers, civil society, and other TB stakeholders, as well as the disability and rehabilitation communities.
Children and young people with developmental disabilities are a large and growing population. But across the world, children and young people with development disabilities have been neglected in services and policy provisions for health and continue to experience stigma, barriers to participation, widespread health inequalities and premature mortality. The aim of this report is to increase awareness of the public health significance of developmental disabilities and the need for increased investment and accountability at all levels. It proposes priority actions to accelerate individual-, family-, community-, and society-level changes to achieve inclusion and health equity.
This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches. Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease
There are three aims of Injured Brains of Medical Minds II - Firstly, to provide perceptive accounts of symptoms and the natural history of brain disorders by people specially trained in the art of observing and reporting, thus yielding unique insights into the lived experience of what it is like to be a patient and to be disabled. Secondly, to offer insights into how the brain works, since the articles are written by patients who are uniquely privileged in view of their understanding of the brain. Thirdly, to highlight ways in which the conditions described in the book can be best managed and treated by healthcare professions and carers. Each chapter includes a set of articles by doctors and other healthcare professionals who have suffered a brain injury illness or brain injury, recounting their experience, accompanied by a commentary for each article. The commentaries critically examine the piece, relating it to current issues in neuropsychology, neurology and cognitive neuroscience. Accounts from over 40 individuals cover a wide range of conditions including: stroke, traumatic brain injury, Alzheimer's Disease and other forms of dementia, brain tumour, infectious and inflammatory conditions, multiple sclerosis, and epilepsy. Summaries are also included of recent books written by doctors/scientists who suffered a brain disorder. This second volume includes totally new articles and commentaries, providing a valuable insight into what it is like to suffer from a brain disorder as well as advice both to patients and practitioners as to what can best be done to improve everyday limitations resulting from a brain disorder. The first volume was published by Oxford University Press in 1997.
Research and innovation are integral parts of the global response to dementia. Yet, the Global status report on the public health response to dementia shows that despite some encouraging efforts most countries are far from reaching the adopted targets of the Global action plan on the public health response to dementia 2017–2025. This blueprint for dementia research summarizes the current state of dementia research across six broad themes, identifies existing knowledge gaps, and outlines 15 strategic goals with actions and timebound milestones to address these gaps. The blueprint also outlines drivers of research that together create an enabling research environment that is essential for accelerating dementia research globally. Going forward, the blueprint will guide policymakers, funders, and the research community on future activities in dementia research, and contribute to making dementia research more efficient, equitable, and impactful.
This integrated operational framework provides an overview of the connections between mental health, neurological and substance use (MNS) conditions, and their links to health, well-being and the broader public health and sustainable development agenda. The need for integrated approaches is increasingly recognized as critical to address the complex interactions between mental health, brain health, substance use, and physical health, particularly in light of global threats such as the COVID-19 pandemic. The framework also provides a series of actions for governments and health service planners and advisors to achieve integration across four domains: leadership and governance; care services; promotion and prevention; and health information systems, evidence generation and research.