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Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. - Describes techniques in the context of important biological problems - Delineates critical steps and potential pitfalls for each method - Includes full-color plates to illustrate techniques
Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The eighth volume of the series features six reviews focusing on NMR spectroscopic techniques in food science, molecular biology and medical diagnosis. The reviews in this volume are: - qNMR as a Tool for Determination of Six Common Sugars in Foods - Correlation of VIP Scores and 1H NMR to Extract Information of Psychological Attention Tests Applied Before and After Coffee Intake - NMR Spectroscopy for Probing the Structural Determinants of Aptamer Optimization and Riboswitch Engineering - Applications of NMR Spectroscopy in Medical Diagnosis - Applications of NMR Spectroscopy in Cancer Diagnosis - NMR as a Tool for Exploring Protein Interactions and Dynamics
Neutron Applications in Earth, Energy and Environmental Sciences offers a comprehensive overview of the wide ranging applications of neutron scattering techniques to elucidate the fundamental materials properties at the nano-, micro- and meso-scale, which underpin research in the related fields of Earth, Energy and Environmental Sciences. Introductions to neutron scattering fundamentals and instrumentation are paired with a thorough review of the applications to a large variety of scientific and technological problems, written through the direct experience of leading scientists in each field. Tailored to a wide audience, this volume provides the novice with an inspiring introduction and stimulates the expert to consider these non-conventional problem solving techniques in his/her field of interest. Earth and environmental scientists, engineers, researchers and graduate students involved with materials science will find Neutron Applications in Earth, Energy and Environmental Sciences a valuable ready-to-use reference.
Answering the need to facilitate quantum-chemical calculations of systems with thousands of atoms, Kazuo Kitaura and his coworkers developed the Fragment Molecular Orbital (FMO) method in 1999. Today, the FMO method can be applied to the study of whole proteins and protein-ligand interactions, and is extremely effective in calculating the propertie
Nanopollutants are nanoparticles that have escaped into the environment and can include engineered nanoparticles as well as nanoparticles that are products of degradation (e.g. nanoplastics) or other processes. As many of these particles are only recently developed or described there is still a lot to learn about where they come from, where they end up and what risks they pose to health and the environment. Offering a wide overview of the most recent research on these emerging contaminants, from the investigation of their sources and fate to the analytical developments for their detection and analysis, this book gives the reader a full picture of the global research on engineered and natural nanoparticles in the environment. Taking a forward-looking perspective with chapters on new nanopollutants, regulatory direction and occurrence in different environmental compartments, this book is a great resource for anyone working in environmental chemistry, nanoscience or environmental regulation.
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Advances in Biotechnology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biotechnology. The editors have built Advances in Biotechnology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biotechnology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Biotechnology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
A NATO Advanced Research Workshop entitled New Methods for the Study of Molecular Aggregates was held at Tbe Lodge at Kananaskis Village, Alberta, Canada from 16 -20 June 1996. In fact the meeting was entirely concerned with the problem of analyzing biomolecular complexes, so the title of these proceedings has been altered to give a more precise description of the content. Tbe workshop was hosted by the time-of-flight group of the Department of Physics at the University of Manitoba, and was attended by 64 participants from around the world. '!\venty-one invited talks were given and 27 papers were presented as posters. Of the 48 contributions, 22 papers (12 orals, 10 posters) are included in these proceedings. Tbe subject of the conference was the investigation of noncovalent biomolecular complexes, with particular focus on the application of mass spectrometry to their characterization. '!\vo new ionization techniques introduced in the late 1980s, electrospray ionization (ES I) and matrix-assisted laser desorptionlionization (MALDI), resulted in a breakthrough in mass spectrometry, enabling its use in molecular weight and primary structure determination of biopolymers larger than 100 kDa. Recently it has been discovered that ESI mass spectrometry mayaiso be used to characterize complexes containing noncovalent interactions, thus opening new perspectives for supramolecular chemistry. ESI mass spectrometry has the advantage that the sampie is introduced from a homogenous solution which can be maintained at near physiological conditions of pR, concentration, and temperature.