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Despite the fame surrounding the name of Louis Pasteur, few people know what exactly occurs at the institute he founded in 1887. Scientific breakthroughs made by pioneers of microbiology, the emergence of molecular biology and genomics, and the identification of VIH–1 in 1983 have kept the Pasteur Institute at the forefront of the fight against infectious diseases. This prestigious private foundation has upheld the vision of its founder, creating a Pasteurian community worldwide, with 33 Pasteur Institutes on five continents, and supported by both famous and unknown donors throughout the world. This book presents the fascinating story of an institution which had enormous influence on both British and American science and medicine. It offers detailed and personal insights into the Pasteur Institute, where lively personalities and outsized passions give birth to excitement and the triumph of world-class research.
In The Private Science of Louis Pasteur, Gerald Geison has written a controversial biography that finally penetrates the secrecy that has surrounded much of this legendary scientist's laboratory work. Geison uses Pasteur's laboratory notebooks, made available only recently, and his published papers to present a rich and full account of some of the most famous episodes in the history of science and their darker sides--for example, Pasteur's rush to develop the rabies vaccine and the human risks his haste entailed. The discrepancies between the public record and the "private science" of Louis Pasteur tell us as much about the man as they do about the highly competitive and political world he learned to master. Although experimental ingenuity served Pasteur well, he also owed much of his success to the polemical virtuosity and political savvy that won him unprecedented financial support from the French state during the late nineteenth century. But a close look at his greatest achievements raises ethical issues. In the case of Pasteur's widely publicized anthrax vaccine, Geison reveals its initial defects and how Pasteur, in order to avoid embarrassment, secretly incorporated a rival colleague's findings to make his version of the vaccine work. Pasteur's premature decision to apply his rabies treatment to his first animal-bite victims raises even deeper questions and must be understood not only in terms of the ethics of human experimentation and scientific method, but also in light of Pasteur's shift from a biological theory of immunity to a chemical theory--similar to ones he had often disparaged when advanced by his competitors. Through his vivid reconstruction of the professional rivalries as well as the national adulation that surrounded Pasteur, Geison places him in his wider cultural context. In giving Pasteur the close scrutiny his fame and achievements deserve, Geison's book offers compelling reading for anyone interested in the social and ethical dimensions of science. Originally published in 1995. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Why did "microbe hunters" at the Pasteur Institute become the most important health experts in the French empire in the early twentieth century? Pasteur's Empire illustrates how French microbiologists transformed life in the colonies in the name of humanitarian public health, which often had grave consequences for those living under French rule.
Essays by leading researchers on the nature and genesis of laboratory medicine.
In Louis Pasteur, the distinguished French immunologist and physician Patrice Debre offers the most extensive, balanced, and detailed account of the scientist's life, struggles, and contributions yet written. First published in France in 1994 to mark the centenary of Pasteur's death in 1895, Debre's biography draws heavily on Pasteur's own scientific notebooks and writings to present a complete critical account of his discoveries and of the controversies they raised with other scientists, occasionally with his closest associates, and with historians ever since. Debre provides an extremely well documented narrative of Pasteur's life and family, as well as his relations with the French government and the established scientific and medical communities. And he places Pasteur in historical context, describing the politics and culture of nineteenth-century France and sketching portraits of the other scientists, including Marcelin Berthelot, Emile Littre, and Claude Bernard, whose life or work became intertwined with Pasteur's.
Retells the life of the famous scientist, including his early life and education, his work on fermentation and microorganisms, and describes how his work lives on today.
Follows the life and career of the French scientist who proved the existence of germs and their connection with diseases.
Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.