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A piercing and scientifically grounded look at the emergence of the coronavirus pandemic and how it will change the way we live—"excellent and timely." (The New Yorker) Apollo's Arrow offers a riveting account of the impact of the coronavirus pandemic as it swept through American society in 2020, and of how the recovery will unfold in the coming years. Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species. Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.
Environmental and Health Management of Novel Coronavirus Disease (COVID-19) examines mitigation measures that can be adopted at the time of a novel coronavirus outbreak to lessen environmental contamination and impacts on human health. The book discusses origin, structure and pathogenesis, epidemiology, environmental transmission and the potential spread routes of COVID-19 via surfaces, air, water, wastewater, medical waste and food products. It also covers guidelines and protocols for setting safety conditions to provide adequate health care and reduce the risk of infection in health and non-healthcare settings, along with preventative measures and disinfection technologies. In addition, the book discusses challenges, opportunities and future perspectives, the global crisis, and global consequences on the environment and health. With contributions from experts, this book presents a multidisciplinary reference resource for virologists, microbiologists, public health professionals, environmental health managers and others engaged in the study and mitigation of the environmental and health impacts of the virus. Covers the environmental transmission and spread of COVID-19 Includes environmental disinfection technologies for prevention of COVID-19 Provides guidelines, standards and protocols related to COVID-19
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Shanghai COVID-19 Medical Treatment Expert Team edits this timely guide for effective prevention and control of COVID-19. Readers will obtain useful guidance on prevention and control of COVID-19 in different places ranging from homes, outdoors, workplaces, etc. You will know 'What is the purpose and significance of home quarantine?', ' When do you need to wear a mask?', 'How should you wash your hands?', 'Do you need to wear a mask in an elevator?', 'What foods are safe to eat and what are not?', 'How to deal with express parcels from major epidemic areas or other areas?' and many other useful tips.Related Link(s)
What are public health services? Countries across Europe understand what they are or what they should include differently. This study describes the experiences of nine countries detailing the ways they have opted to organize and finance public health services and train and employ their public health workforce. It covers England France Germany Italy the Netherlands Slovenia Sweden Poland and the Republic of Moldova and aims to give insights into current practice that will support decision-makers in their efforts to strengthen public health capacities and services. Each country chapter captures the historical background of public health services and the context in which they operate; sets out the main organizational structures; assesses the sources of public health financing and how it is allocated; explains the training and employment of the public health workforce; and analyses existing frameworks for quality and performance assessment. The study reveals a wide range of experience and variation across Europe and clearly illustrates two fundamentally different approaches to public health services: integration with curative health services (as in Slovenia or Sweden) or organization and provision through a separate parallel structure (Republic of Moldova). The case studies explore the context that explain this divergence and its implications. This study is the result of close collaboration between the European Observatory on Health Systems and Policies and the WHO Regional Office for Europe Division of Health Systems and Public Health. It accompanies two other Observatory publications Organization and financing of public health services in Europe and The role of public health organizations in addressing public health problems in Europe: the case of obesity alcohol and antimicrobial resistance (both forthcoming).
Developed by WHO and the International Committee of the Red Cross, in collaboration with the International Federation for Emergency Medicine, "Basic Emergency Care (BEC): Approach to the acutely ill and injured" is an open-access training course for frontline healthcare providers who manage acute illness and injury with limited resources.BEC teaches a systematic approach to the initial assessment and management of time-sensitive conditions where early intervention saves lives. It includes modules on: the ABCDE and SAMPLE history approach, trauma, difficulty in breathing, shock, and altered mental status. The practical skills section covers the essential time-sensitive interventions for these key acute presentations.The BEC package includes a Participant Workbook and electronic slide decks for each module. BEC integrates the guidance from WHO Emergency Triage, Assessment and Treatment (ETAT) for children, WHO Pocket Book of Hospital Care for Children, WHO Integrated Management of Pregnancy and Childbirth and the Integrated Management of Adult/Adolescent Illness (IMAI).
This book assesses the main features of COVID-19 from a clinical point of view, based on observations made during the disease epidemic in Northern Italy, one of the most affected areas in the world (the region has been the epicenter of the global pandemic for more than a month), and the first region outside China facing overwhelming numbers of cases. With no practical guidelines in place, Italian doctors were called to fight against an unknown disease. For the first time in modern history, healthcare workers and decision-makers had to find rapid solutions to a life-changing health crisis with no evidence-based recommendations or procedures in place to guide their actions. Sharing the lessons learned from this experience, and offering practical tips on implementing future programs for pandemic preparedness, the book is a valuable tool for medical practitioners and health-policy-makers wanting to better understand the complexity of the current and future global health crises.
This fully updated edition of Infectious Disease Surveillance is for frontline public health practitioners, epidemiologists, and clinical microbiologists who are engaged in communicable disease control. It is also a foundational text for trainees in public health, applied epidemiology, postgraduate medicine and nursing programs. The second edition portrays both the conceptual framework and practical aspects of infectious disease surveillance. It is a comprehensive resource designed to improve the tracking of infectious diseases and to serve as a starting point in the development of new surveillance systems. Infectious Disease Surveillance includes over 45 chapters from over 100 contributors, and topics organized into six sections based on major themes. Section One highlights the critical role surveillance plays in public health and it provides an overview of the current International Health Regulations (2005) in addition to successes and challenges in infectious disease eradication. Section Two describes surveillance systems based on logical program areas such as foodborne illnesses, vector-borne diseases, sexually transmitted diseases, viral hepatitis healthcare and transplantation associated infections. Attention is devoted to programs for monitoring unexplained deaths, agents of bioterrorism, mass gatherings, and disease associated with international travel. Sections Three and Four explore the uses of the Internet and wireless technologies to advance infectious disease surveillance in various settings with emphasis on best practices based on deployed systems. They also address molecular laboratory methods, and statistical and geospatial analysis, and evaluation of systems for early epidemic detection. Sections Five and Six discuss legal and ethical considerations, communication strategies and applied epidemiology-training programs. The rest of the chapters offer public-private partnerships, as well lessons from the 2009-2010 H1N1 influenza pandemic and future directions for infectious disease surveillance.
When working with countries to measure and compare health systems functioning, it is important to strike a good balance between avoiding blueprints that do not allow for country contexts and specificities while also encouraging a degree of standardization that enables comparisons within and between countries as well as over time. Standardized indicators allow comparisons between countries and can help mutual learning, including the identification of bottlenecks and the sharing of lessons learned. This handbook does not attempt to cover all components of the health system or deal with the various monitoring and evaluation frameworks. Instead, it is structured around the WHO framework that describes health systems in terms of six core components or "building blocks": service delivery, health workforce, health information systems, medical products, vaccines and technologies, financing and leadership/governance. The selection of indicators was guided by the need to detect change and show progress in health systems strengthening. Indicators relate to both the level and distribution of inputs and outputs. While the focus is on low- and middle-income countries, experiences from high-income countries are also used to guide the development of measurement systems. Each section has proposed core indicators that all countries are encouraged to collect, plus a wider set of indicators that users can choose or modify as needed. It is anticipated that the core indicators will enable the production of country "dashboards" that contain the instruments by which health systems trends can be regularly monitored and compared. Countries should integrate new indicators with existing indicators of their health sector and statistical strategies and plans. Health systems monitoring should also be seen in the context of the indicators' impact on access to priority health services and their contribution to reaching the Millennium Development Goals (MDGs). The handbook is divided into six sections, each of which covers one health system component or building block and is set out along the following lines: -introduction to the component and related indicators; -description of possible sources of information and available measurement strategies; -proposed "core indicators", supplemented, where necessary, by additional indicators that may be used depending on the country health system attributes and needs.