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"Contains materials originally published in single magazine form Injection #1-15."
Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
Chapters by a distinguished group of international authors on various aspects of Underground Injection Science and Technology are organized into seven sections addressing specific topics of interest. In the first section the chapters focus on the history of deep underground injection as well regulatory issues, future trends and risk analysis. The next section contains ten chapters dealing with well testing and hydrologic modeling. Section 3, consisting of five chapters, addresses various aspects of the chemical processes affecting the fate of the waste in the subsurface environment. Consideration is given here to reactions between the waste and the geologic medium, and reactions that take place within the waste stream itself. The remaining four sections deal with experience relating to injection of, respectively, liquid wastes, liquid radioactive wastes in Russia, slurried solids, and compressed carbon dioxide. Chapters in Section 4, cover a diverse range of other issues concerning the injection of liquid wastes including two that deal with induced seismicity. In Section 5, Russian scientists have contributed several chapters revealing their knowledge and experience of the deep injection disposal of high-level radioactive liquid processing waste. Section 6 consists of five chapters that cover the technology surrounding the injection disposal of waste slurries. Among the materials considered are drilling wastes, bone meal, and biosolids. Finally, four chapters in Section 7 deal with questions relating to carbon dioxide sequestration in deep sedimentary aquifers. This subject is particularly topical as nations grapple with the problem of controlling the buildup of carbon dioxide in the atmosphere.* Comprehensive coverage of the state of the art in underground injection science and technology* Emerging subsurface waste disposal technologies* International scope
Direct injection enables precise control of the fuel/air mixture so that engines can be tuned for improved power and fuel economy, but ongoing research challenges remain in improving the technology for commercial applications. As fuel prices escalate DI engines are expected to gain in popularity for automotive applications. This important book, in two volumes, reviews the science and technology of different types of DI combustion engines and their fuels. Volume 1 deals with direct injection gasoline and CNG engines, including history and essential principles, approaches to improved fuel economy, design, optimisation, optical techniques and their applications. - Reviews key technologies for enhancing direct injection (DI) gasoline engines - Examines approaches to improved fuel economy and lower emissions - Discusses DI compressed natural gas (CNG) engines and biofuels
Metal injection molding combines the most useful characteristics of powder metallurgy and plastic injection molding to facilitate the production of small, complex-shaped metal components with outstanding mechanical properties. Handbook of Metal Injection Molding, Second Edition provides an authoritative guide to this important technology and its applications. Building upon the success of the first edition, this new edition includes the latest developments in the field and expands upon specific processing technologies. Part one discusses the fundamentals of the metal injection molding process with chapters on topics such as component design, important powder characteristics, compound manufacture, tooling design, molding optimization, debinding, and sintering. Part two provides a detailed review of quality issues, including feedstock characterisation, modeling and simulation, methods to qualify a MIM process, common defects and carbon content control. Special metal injection molding processes are the focus of part three, which provides comprehensive coverage of micro components, two material/two color structures, and porous metal techniques, as well as automation of the MIM process and metal injection molding of large components. Finally, part four explores metal injection molding of particular materials, and has been expanded to include super alloys, carbon steels, precious metals, and aluminum. With its distinguished editor and expert team of international contributors, the Handbook of Metal Injection Molding is an essential guide for all those involved in the high-volume manufacture of small precision parts, across a wide range of high-tech industries such as microelectronics, biomedical and aerospace engineering. Provides an authoritative guide to metal injection molding and its applications Discusses the fundamentals of the metal injection molding processes and covers topics such as component design, important powder characteristics, compound manufacture, tooling design, molding optimization, debinding, and sintering Comprehensively examines quality issues such as feedstock characterization, modeling and simulation, common defects and carbon content control
The injection of cosmetic neurotoxins and fillers is a multi-billion dollar industry in which facial plastic surgeons, plastic surgeons, dermatologists, oculoplastic surgeons, and paraprofessionals in the U.S. perform more than seven million injections annually. Cosmetic Injection Techniques and the videos that accompany it provide all medical professionals in the field (from beginners to experienced injectors) with practical information on how to properly administer neurotoxin and filler injections for conditions such as lower eyelid roll, nasal flare, platysmal banding, marionette lines, glabellar frown lines, and much more. Key Features: Full color, detailed illustrations describe key anatomical landmarks and identify exact injection locations Online access to videos narrated by Dr. Kontis that demonstrate multiple injection techniques A unique rating system for each procedure, enabling injectors to perform techniques appropriate to their skill level Every commonly performed cosmetic injection procedure is covered, giving readers a comprehensive guide on how to safely and effectively perform injections This easy-to-use manual gives facial plastic surgeons, plastic surgeons, dermatologists, oculoplastic surgeons and other medical professionals authoritative, concise information on the anatomy, techniques, precautions, complications, and post-treatment care involved in the administration of injections of cosmetic neurotoxins and fillers.
This comprehensive and unique handbook of split and splitless injection techniques has been completely revised and updated. This new edition offers: - New insights concerning sample evaporation in the injector - Information about matrix effects - A new chapter on injector design The real processes within the injector are for the first time visualized and explained by the CD-ROM included in the book. Furthermore the reader will understand the concepts of injection techniques and get a knowledge of the sources of error. The handbook also includes many practical guidelines. From reviews of former editions: "This substantial book is on injection techniques alone, which ... demonstrates this can have many pitfalls ... no one should be allowed to direct a laboratory doing quantitative analysis by GC without first being thoroughly familar with this book ..." The Analyst "This is a detailed reference volume filled with practical suggestions and techniques for managing split and splitless injection in the day-to-day world of the working gas chromatographer. It will be useful ... for anyone who must work hands-on with GC." Journal of High Resolution Chromatography
What is SQL injection? -- Testing for SQL injection -- Reviewing code for SQL injection -- Exploiting SQL injection -- Blind SQL injection exploitation -- Exploiting the operating system -- Advanced topics -- Code-level defenses -- Platform level defenses -- Confirming and recovering from SQL injection attacks -- References.
The quintessential visual guide to facial aesthetic enhancement and dermal filler injection techniques from top experts In-depth and detailed knowledge of anatomy, different facial shapes, and ethnic origins is essential to delivering safe, effective, natural, and harmonious aesthetic facial treatment results. Dermal Fillers: Facial Anatomy and Injection Techniques is the culmination of many years of expertise decrypting facial anatomy as it applies to aesthetic enhancement of the face. This visually rich atlas is authored by internationally renowned Brazilian dermatologists André Braz, an esteemed expert in the use of botulinum toxin, fillers, and lasers; and Thais Sakuma, a distinguished lecturer in the application of botulinum toxin and hyaluronic acid fillers. Nineteen highly practical, concise, and didactic chapters are organized consistently with structured text at the beginning of each chapter. The book encompasses the application of injection techniques for the full spectrum of indications, from softening wrinkles to facial contouring. Important topics include facial assessment, hyaluronic acid science, facial aging, and regional nerve blocks for pain management. Meticulous anatomic descriptions and images depict the relationships between superficial and deeper structures such as vasculature, thereby providing vital knowledge to help clinicians avoid potentially serious complications. Key Features: Systematic organization based on aesthetic zones, from superficial to deep Richly illustrated, with 1664 outstanding drawings, remarkable cadaver dissection images, and patient photos Seventeen concise video sequences elucidate key injection techniques Comprehensive coverage of potential complications, such as unintended injection of filler into vasculature Expert discussion of safety issues, potential pitfalls, and the naturalness of expected outcomes This is the ultimate resource for all dermatologists, plastic surgeons, and non–core practitioners who wish to expand their practices to offer complex facial cosmetic injection techniques and achieve optimal patient outcomes.
Comprehensive Atlas of Ultrasound-Guided Pain Management Injection Techniquesdepicts in crisp, step-by-step detail how to prepare and perform injections under ultrasound guidance. Over 160 ultrasound-guided injection techniques are depicted in short, easy to review chapters with hundreds of full color photographs and illustrations. The accompanying website presents many of these techniques in video. Coverage includes techniques for head, neck, shoulder, elbow and forearm, wrist and hand, chest wall, trunk and abdomen, low back, hip and pelvis, knee and lower extremity, and foot and ankle. Visualizing patient anatomy and correlating it to ultrasound output is a crucial skill for these procedures, and is clearly demonstrated with anatomical illustrations placed side-by-side with ultrasound images. Transducer positioning and proper needle angle are also clearly demonstrated in illustrations, photographs, and in video accompanying the text. . This text demonstrates the ease and utility of ultrasound in a comprehensive, aesthetically pleasing layout. Images are oversized for viewing ease and text is direct, succinct, and easy to read. FEATURES: Each technique will illustrate the relevant anatomy Each technique is accompanied by full-color illustrations and photographs Uses a step-by-step, how-to approach to describe each technique Accompanying videos further illustrate the techniques