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Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians. Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems
Hydrogels represent one of the cornerstones in tissue engineering and regenerative medicine, due to their biocompatibility and physiologically relevant properties. These inherent characteristics mean that they can be widely exploited as bioinks in 3D bioprinting for tissue engineering applications as well as injectable gels for cell therapy and drug delivery purposes. The research in these fields is booming and this book provides the reader with a terrific introduction to the burgeoning field of injectable hydrogel design, bioprinting and tissue engineering. Edited by three leaders in the field, users of this book will learn about different classes of hydrogels, properties and synthesis strategies to produce bioinks. A section devoted to the key processing and design challenges at the hydrogel/3D bioprinting/tissue interface is also covered. The final section of the book closes with pertinent clinical applications. Tightly edited, the reader will find this book to be a coherent resource to learn from. It will appeal to those working across biomaterials science, chemical and biomedical engineering, tissue engineering and regenerative medicine.
There have been important developments in materials and therapies for the treatment of spinal conditions. Biomaterials for spinal surgery summarises this research and how it is being applied for the benefit of patients. After an introduction to the subject, part one reviews fundamental issues such as spinal conditions and their pathologies, spinal loads, modelling and osteobiologic agents in spinal surgery. Part two discusses the use of bone substitutes and artificial intervertebral discs whilst part three covers topics such as the use of injectable biomaterials like calcium phosphate for vertebroplasty and kyphoplasty as well as scoliosis implants. The final part of the book summarises developments in regenerative therapies such as the use of stem cells for intervertebral disc regeneration. With its distinguished editors and international team of contributors, Biomaterials for spinal surgery is a standard reference for both those developing new biomaterials and therapies for spinal surgery and those using them in clinical practice. Summarises recent developments in materials and therapies for the treatment of spinal conditions and examines how it is being applied for the benefit of patients Reviews fundamental issues such as spinal conditions and their pathologies, spinal loads, modelling and osteobiologic agents in spinal surgery Discusses the use of bone substitutes and artificial intervertebral discs and covers topics such as the use of injectable biomaterials like calcium phosphate for vertebroplasty and kyphoplasty
Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials
This chapter discusses recent developments of injectable biomimetic hydrogel systems found in soft tissue repair applications. It begins by introducing how biomimesis and biomaterials are related, and how tissue repair systems can be considered biomimetic. We introduce hydrogels by discussing their classification, synthesis and applications, then discuss how injectable biomimetic hydrogels have been investigated for use in soft tissue repair. Different approaches to the use of biomimetic hydrogels for soft tissue repair are covered, focusing on synthetic, non-biodegrable polymers. We include so-called conventional polymers and more biomimetic polymers. The chapter concludes with the likely future trends and highlights further reading materials.
"Regenerative engineering, with its ability to foster novel therapeutic techniques and strategies, has emerged as the most versatile and innovative technology of the 21st century. The past few years have seen a significant interest in the development of injectable hydrogels as a delivery system to realize the dream of regenerative engineering. The book will explain synthetic approaches towards developing injectable hydrogels, and the clinical implications and applications of injectable hydrogels for engineering various tissues. Injectable Hydrogels for Regenerative Engineering is the first of its kind to bring together the fields of injectable hydrogels and regenerative engineering to give a perspective of the emerging therapeutic strategies for a wide audience."--
Injectable smart hydrogels possess various properties that enable the development of new minimally invasive approaches to avoid problems associated with traditional implants. Researchers in academia and industry will learn the range of synthetic strategies used to produce this emerging class of biomaterials. Clinicians will also be inspired by the range of applications demonstrated to advance surgical procedures. The editors have brought together a global authorship to ensure that this book presents the state-of-the-art in materials engineering and therapeutics. Their knowledge and experience will help the reader develop better knowledge of the field and inspire new innovations, that cover a range of areas such as regenerative medicine, cancer therapy, and drug delivery.
This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.
This excellent textbook provides up-to-date information on all aspects of pelvic floor disorders. After an opening section on anatomy and physiology, it explains the methodology, role and application of the integrated imaging approach in detail, including the most advanced 3D, 4D, and dynamic ultrasound techniques, illustrated with hundreds of images. It then discusses in depth the epidemiology, etiology, assessment, and management of the full range of pelvic floor disorders from multidisciplinary and practical perspectives. The book also provides information on the various forms of obstetric perineal trauma, urinary incontinence and voiding dysfunction, anal incontinence, pelvic organ prolapse, constipation and obstructed defecation, pelvic pain and sexual dysfunction, and fistulas, and includes treatment algorithms as well as helpful guidance on what to do when surgical treatment goes wrong. The authors are leading experts in the field from around the globe. Since the first edition from 2010 (more than 200,000 chapter downloads), the book has been extensively rewritten and features numerous additional topics. The result is a comprehensive textbook that is invaluable for gynecologists, colorectal surgeons, urologists, radiologists, and gastroenterologists, beginners and veterans alike.