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Research suggests an early start is the key to a successful intervention for children diagnosed with an autism spectrum disorder. What many don't know is that research also shows that for most early intervention programs to be effective, they must involve a child's primary caregivers, especially when it comes to such an all-pervasive area as communication. This book does not advocate that parents steer clear of therapists and specialists. Instead, it attempts to put more control in the parents' hands.Without adding to parents' already busy schedules, Teresa Cardon, a speech language pathologist and author of best-selling Let's Talk Emotions (see page 33), discusses the importance of creating a communication environment in the home. Simple everyday tools include deliberate use of books, toys, visual schedules, and labeling, among others.
The Handbook of Relationship Initiation is the first volume to focus specifically on the very beginning stage of relationships – their origin. In this Handbook, leading scholars on relationships review the literature on various processes related to the initiation of relationships: how people meet, communicate for the first time, and begin to define themselves as being in a relationship. Topics include attraction, mate selection, influence of social networks on relationship initiation, initiation over the internet, hook-ups among young adults, and flirting and opening gambits. In addition, the dark side of relationship initiation is considered, including unwanted relationship pursuit and barriers to relationship initiation including social anxiety. This volume provides an overdue synthesis of the literature on this topic. It is especially timely in view of the growing prevalence on relationship initiation online, through matchmaking and other social networking sites, which has increased awareness that science can be used to understand, create, and facilitate compatible matching. This Handbook provides an essential resource for an interdisciplinary range of researchers and students who study relationships, including social psychologists, communication scientists and scholars of marriage and the family.
Atypical Interaction presents a state-of-the-art overview of research which uses conversation analysis to explore how communicative impairments impact on conversation and other forms of talk and social interaction. Although the majority of people use spoken language unproblematically in social interaction, many individuals have an atypical capacity for communication. The first collection of its kind, this book examines a wide range of conditions where the communication of children or adults is atypical, including autism spectrum disorder, dementia, stammering, hearing impairment, schizophrenia, dysarthria and aphasia. By analyzing recordings of real-life interactions, the collection highlights not only the communication difficulties and challenges faced by atypical communicators and their interlocutors in everyday life, but also the competences and often novel forms of communication displayed. With fourteen empirical chapters from leading scholars in the field and an introductory chapter which provides a background to conversation analysis and its application to the study of atypical interactions, the collection will be an invaluable resource for students, practitioners such as speech and language therapists, and researchers with an interest in human communication, communication diversity and disorder.
The Initiation of DNA Replication contains the proceedings of the 1981 ICN-UCLA Symposia on Structure and DNA-Protein Interactions of Replication Origins, held in Salt Lake City, Utah on March 8-13, 1981. The papers explore the initiation of DNA replication and address relevant topics such as whether there are specific protein recognition sites within an origin; how many proteins interact at an origin and whether they interact in a specific temporal sequence; or whether origins can be subdivided into distinct functional domains. The specific biochemical steps in DNA chain initiation and how they are catalyzed are also discussed. This book is organized into six sections and comprised of 41 chapters. The discussion begins by analyzing the replication origin region of the Escherichia coli chromosome and the precise location of the region carrying autonomous replicating function. A genetic map of the replication and incompatibility regions of the resistance plasmids R100 and R1 is described, and several gene products produced in vivo or in vitro from the replication region are considered. The sections that follow focus on the DNA initiation determinants of bacteriophage M13 and of chimeric derivatives carrying foreign replication determinants; suppressor loci in E. coli; and enzymes and proteins involved in initiation of phage and bacterial chromosomes. The final chapters examine the origins of eukaryotic replication. This book will be of interest to scientists, students, and researchers in fields ranging from microbiology and molecular biology to biochemistry, molecular genetics, and physiology.
For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.
This treatise is focused on early aspects of fungal pathogenesis in plant and animal hosts. Our aim in choosing the topics and contributors was to demonstrate common approaches to studies of fungal-plant and fungal-animal interactions, particularly at the biochemical and molecular Ievels. For example, the initial events of adh«sion of fungal spores to the exposed surface tissues of the host are essential for subsequent invasion of the plant or animal and establishment of pathogenesis. A point of consensus among investigators who have directed their attention to such events in plants, insects, and vertebrates isthat spore adhesion to the host cuticle or epithelium is more than a simple binding event. lt is a complex and potentially pivotal process in fungal-plant interactions which "may involve the secretion of ftuids that prepare the infection court for the development of morphological stages of the germling" and subsequent invasion of the host (Nicholson and Epstein, Chapter 1). The attachment of the fungal propagule to the arthropod cuticle is also "mediated by the chemical components present on the outer layer of the spore wall and the epicuticle . . . . Initial attachment may be reinforced further by either the active secretion of adhesive materials or the modification of spore wall materiallocated at the [fungal spore arthropod] cuticle interface (Boucias and Pendland, Chapter 5).
Cancer is characterized by heterogeneous cells with capacity for self renewal, and selective pressures in the microenvironment which constantly change the cell population. This "descent with modification" is consistent with Darwin's definition of evolution, and accordingly, cancer progression can be captured from an evolutionary angle. However, there is also a clear difference between cancer progression and biological evolution. First, contrary to the evolution of complex organisms, cancer originates from cells of multicellular organisms that escape their constraints and behave like unicellular organisms. Therefore, from the beginning, cancer cells have complex genomes that contain abundant genetic materials which they can use to change their phenotype by dynamic rearrangements and modifications. Secondly, epigenetic effects promote cancer evolution in contrast to the evolution of life. Some tumors develop with minimal genetic alterations, and cell plasticity contributes to both initiation and progression in various tumors. However, an evolutionary theory that encompasses these characteristics of cancer remains to be developed.
For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the first of three on the topic of Translation Initiation includes articles written by leaders in the field.
​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
Progress in Behavior Modification, Volume 11 covers the developments in the study of behavior modification. The book discusses the pluralistic psychology of behavior change; the methodological issues in child behavior therapy; and the interpersonal-skills training with adolescents. The text also describes the behavior modification of work and work-related problems; the behavioral treatment of migraine and muscle-contraction headaches; and the modification of children's social withdrawal. An assessment of hyperactive children, with regard to the psychometric, methodological, and practical considerations, is considered. Psychologists, psychiatrists, and sociologists will find the book invaluable.