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Written by practitioners experienced in the field, 'Practical Radiation Protection in Healthcare' provides a practical guide for medical physicists and others involved with radiation protection in the healthcare environment.
Over the past decade significant progress has been achieved in the development of waste characterization and control procedures and equipment as a direct response to ever-increasing requirements for quality and reliability of information on waste characteristics. Failure in control procedures at any step can have important, adverse consequences and may result in producing waste packages which are not compliant with the waste acceptance criteria for disposal, thereby adversely impacting the repository. The information and guidance included in this publication corresponds to recent achievements and reflects the optimum approaches, thereby reducing the potential for error and enhancing the quality of the end product. -- Publisher's description.
Growing public concern about releases of radiation into the environment has focused attention on the measurement of exposure of people living near nuclear weapons production facilities or in areas affected by accidental releases of radiation. Radiation-Dose Reconstruction for Epidemiologic Uses responds to the need for criteria for dose reconstruction studies, particularly if the doses are to be useful in epidemiology. This book provides specific and practical recommendations for whether, when, and how studies should be conducted, with an emphasis on public participation. Based on the expertise of scientists involved in dozens of dose reconstruction projects, this volume: Provides an overview of the basic requirements and technical aspects of dose reconstruction. Presents lessons to be learned from dose reconstructions after Chernobyl, Three Mile Island, and elsewhere. Explores the potential benefits and limitations of biological markers. Discusses how to establish the "source term"â€"that is, to determine what was released. Explores methods for identifying the environmental pathways by which radiation reaches the body. Offers details on three major categories of dose assessment.
This book is dedicated to the great scientist and outstanding individual Nikolay Wladimirovich Timofeeff-Ressovsky. The book brings together a number of brief stories/essays about Timofeeff-Ressovsky including “Stories told by himself”, and scientific chapters addressing his major research areas: genetics, radiobiology, radiation ecology and epidemiology, and evolution. Timofeeff-Ressovsky contributed to several fields of biology and established new directions of scientific research. He often repeated the phrase, which would later become famous: “Science should not be approached with the ferocity of wild animals”. In keeping with that philosophy, the issues discussed here are still open. Each scientific part starts with a current review; the chapters present leading scientific schools and views. The main theme discussed in the genetics part is mutation variability in the context of linear (replication, transcription, translation) and conformational template processes, and its dependence on phylogenetic group. In turn, the radiobiology chapters focus on the reorganization of DNA, cell, and population variability under low-dose irradiation, sparking indirect processes and adaptive response. The radiation ecology and epidemiology parts present data on the consequences of nuclear plants and related accidents for ecological systems and human beings. Here some approaches to estimating radiation risks are also offered. Evolution laws are demonstrated in the genomic universe, plant-microbe symbiosis, stabilizing and destabilizing (directional) selection. The last essay demonstrates the principles of organization operating in local animal populations, which are approached as social organisms of complex systemic nature. The chapter 'Radiation-Induced Aging and Genetic Instability of Mesenchymal Stem Cells: An Issue for Late Health Effects?' is available open access under a CC BY 4.0 license.
Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.
Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. - Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics - Provides the reader with a better understanding on how to design and implement early phase oncology trials - Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development