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In the last six months, Ashley's life has been one disappointment after another. She walked in on her boyfriend with another woman, leaving her needing a new place to live and a mountain of debt. As if that wasn't enough, her ex convinces her that his infidelity is her fault for being unadventurous in bed. Deep down Ashley has always had the desire to be wild but has been held back by her own insecurities. She's desperate to break free, but she's fearful of how people will judge her if they know her inner desires. She wants nothing more than to lose herself in sex that pushes her to the limit, but she hasn't found anyone she trusts enough to take her there until she meets Tanner. Tanner doesn't trust anyone outside of his inner circle easily. The infamous, media proclaimed playboy, quarterback is tired of people using him for money, connections and to get their fifteen minutes of fame. Determined to protect his image and himself, he makes sure to keep most people at arm's length until Ashley is thrown into his life. He's inexplicably drawn to her, and she needs his help in more ways than one. But to help her, he'll need to let her in. There's an immediate attraction and connection that neither can deny, but can both of them get past their inhibitions and find what they are looking for in each other or will everything backfire in their faces?
This vintage text contains Sigmund Freud's seminal essay, "Inhibitions, Symptoms and Anxiety". Although 'symptoms' and 'inhibitions' appear to be unconnected phenomena, the fact that in some disorders and illnesses there are only symptoms, and in others only inhibitions - seems to indicate that there may be a connection between the two. This fascinating treatise by the father of psychoanalysis explores this connection, and examines what it may mean for psychoanalytical paradigms. This text is highly recommended for anyone interested in psychoanalysis or the work of the great Sigmund Freud, and it will be of special utility to students of psychology. Sigmund Freud (1856 - 1939) was an Austrian neurologist widely considered to be the father of psychoanalysis. We are republishing this antiquarian volume in an affordable, modern edition complete with a specially commissioned new biography of the author.
This book examines three decades of research on behavioral inhibition (BI), addressing its underlying biological, psychological, and social markers of development and functioning. It offers a theory-to-practice overview of behavioral inhibition and explores its cognitive component as well as its relationship to shyness, anxiety, and social withdrawal. The volume traces the emergence of BI during infancy through its occurrences across childhood. In addition, the book details the biological basis of BI and explores ways in which it is amenable to environmental modeling. Its chapters explore the neural systems underlying developmental milestones, address lingering questions (e.g., limitations of studying BI in laboratory settings and debatable benefits of self-regulatory processes), and provide recommendations for future research. Key areas of coverage include: Animal models of behavioral inhibition. Social functioning and peer relationships in BI. Attention mechanisms in behavioral inhibition. BI and associative learning of fear. Behavioral inhibition and prevention of internalizing distress in early childhood. The relations between BI, cognitive control, and anxiety. Behavioral Inhibition is a must-have resource for researchers, clinicians, scientist-practitioners, and graduate students across such fields as developmental psychology, psychiatry, social work, cognitive and affective developmental neuroscience, child and school psychology, educational psychology, and pediatrics.
A book to cover developments in corrosion inhibitors is long overdue. This has been addressed by Dr Sastri in a book which presents fundamental aspects of corrosion inhibition, historical developments and the industrial applications of inhibitors. The book deals with the electrochemical principles and chemical aspects of corrosion inhibition, such as stability of metal complexes, the Hammett equation, hard and soft acid and base principle, quantum chemical aspects and Hansch' s model and also with the various surface analysis techniques, e.g. XPS, Auger, SIMS and Raman spectroscopy, that are used in industry for corrosion inhibition. The applications of corrosion inhibition are wide ranging. Examples given in this book include: oil and gas wells, petrochemical plants, steel reinforced cement, water cooling systems, and many more. The final chapters discuss economic and environmental considerations which are now of prime importance. The book is written for researchers in academia and industry, practicing corrosion engineers and students of materials science, engineering and applied chemistry.
In the last six months, Ashley’s life has been one disappointment after another. She walked in on her boyfriend with another woman, leaving her needing a new place to live and a mountain of debt. As if that wasn’t enough, her ex convinces her that his infidelity is her fault for being unadventurous in bed. Deep down Ashley has always had the desire to be wild but has been held back by her own insecurities. She’s desperate to break free, but she's fearful of how people will judge her if they know her inner desires. She wants nothing more than to lose herself in sex that pushes her to the limit, but she hasn’t found anyone she trusts enough to take her there until she meets Tanner. Tanner doesn’t trust anyone outside of his inner circle easily. The infamous, media proclaimed playboy, quarterback is tired of people using him for money, connections and to get their fifteen minutes of fame. Determined to protect his image and himself, he makes sure to keep most people at arm’s length until Ashley is thrown into his life. He’s inexplicably drawn to her, and she needs his help in more ways than one. But to help her, he’ll need to let her in. There’s an immediate attraction and connection that neither can deny, but can both of them get past their inhibitions and find what they are looking for in each other or will everything backfire in their faces?
Gorfein and MacLeod have compiled a collection of chapters written by top researchers in psychology discussing the concept of inhibition at the level of cognition and behavior. This work thoroughly addresses the concept of inhibition and covers the broad range of cognition, from attention and performance through memory and language.
"Frontiers in Anti-Cancer Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug di
Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"
Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.