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This thesis presents the design, modeling, and control of a magnetic artificial cilia system in which the cilia are individually controllable. In nature, cilia exhibit metachronal waves, or a phase difference between adjacent cilia that results in a traveling wave, which may improve pumping performance or efficiency of biological cilia. However, existing magnetic artificial cilia devices typically use actuation by a rotating field generated by Helmholtz coils or by a rotating permanent magnet. These field sources cannot apply a phase shift to the cilia array and therefore cannot generate a metachronal wave. Nevertheless, magnetic actuation remains desirable for cilia devices as it allows for biocompatibility, precise control of sys- tem inputs, and low-cost fabrication of the cilia. In this thesis, a new design for magnetic artificial cilia is presented in which the actuating magnetic field is localized, enabling indi- vidual actuation. However, this design decision leads to challenging research problems in input-pattern identification, nonlinear systems modeling, and control. In addressing these challenges, the contributions of this thesis are to (i) demonstrate that individual control can improve performance in cilia-based devices, (ii) present accurate nonlinear models for pre- dicting the static response, and (iii) develop a machine-learning-based system identification and control strategy for output tracking.
This book gives an overview of the research field of artificial cilia, a novel technology for controlling and sensing fluid flow at microscopic scales. This field is inspired by nature, namely by naturally occurring cilia which are tiny hairs covering biological cells and that are used already for over a billion years by nature to generate and sense fluid flow. The research field started less than a decade ago and has grown fast in recent years, since it offers very interesting options for flow control in lab-on-a-chip devices.
Mixing may be thought of as the operation by which a system evolves from one state of simplicity (initial segregation) to another state of simplicity (complete uniformity). Between these two extremes, complex patterns emerge and die. Questions naturally arise- how can the geometry of complex patterns be characterised, what is the time scale of the process, what structures are involved in the flow? This volume, comprising the proceedings of the NATO ASI on Mixing, attempts to address these questions from the approaches of geometry, kinetics and structure. The ASI which brought together diverse communities with a common interest in the problem of mixing, now provides us with a comprehensive work on the problem of mixing.
The application of Micro Electro Mechanical Systems (MEMS) in the biomedical field is leading to a new generation of medical devices. MEMS for biomedical applications reviews the wealth of recent research on fabrication technologies and applications of this exciting technology.The book is divided into four parts: Part one introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms. Part two describes applications of MEMS for biomedical sensing and diagnostic applications. MEMS for in vivo sensing and electrical impedance spectroscopy are investigated, along with ultrasonic transducers, and lab-on-chip devices. MEMS for tissue engineering and clinical applications are the focus of part three, which considers cell culture and tissue scaffolding devices, BioMEMS for drug delivery and minimally invasive medical procedures. Finally, part four reviews emerging biomedical applications of MEMS, from implantable neuroprobes and ocular implants to cellular microinjection and hybrid MEMS.With its distinguished editors and international team of expert contributors, MEMS for biomedical applications provides an authoritative review for scientists and manufacturers involved in the design and development of medical devices as well as clinicians using this important technology. Reviews the wealth of recent research on fabrication technologies and applications of Micro Electro Mechanical Systems (MEMS) in the biomedical field Introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms Considers MEMS for biomedical sensing and diagnostic applications, along with MEMS for in vivo sensing and electrical impedance spectroscopy
This book describes the substantial progress recently made in the development of micro and nanorobotic systems, utilizing magnetic, optical, acoustic, electrical, and other actuation fields. It covers several areas of micro and nanorobotics including robotics, materials science, and biomedical engineering. Field-Driven Micro and Nanorobots for Biology and Medicine provides readers with fundamental physics at the micro and nano scales, state-of-the-art technical advances in field-driven micro and nanorobots, and applications in biological and biomedical disciplines.
Microbiorobotics is a new engineering discipline that inherently involves a multidisciplinary approach (mechanical engineering, cellular biology, mathematical modeling, control systems, synthetic biology, etc). Building robotics system in the micro scale is an engineering task that has resulted in many important applications, ranging from micromanufacturing techniques to cellular manipulation. However, it is also a very challenging engineering task. One of the reasons is because many engineering ideas and principles that are used in larger scales do not scale well to the micro-scale. For example, locomotion principles in a fluid do not function in the same way, and the use of rotational motors is impractical because of the difficulty of building of the required components. Microrobotics is an area that is acknowledged to have massive potential in applications from medicine to manufacturing. This book introduces an inter-disciplinary readership to the toolkit that micro-organisms offer to micro-engineering The design of robots, sensors and actuators faces a range of techology challenges at the micro-scale. This book shows how biological techniques and materials can be used to meet these challenges World-class multi-disciplanry editors and contributors leverage insights from engineering, mathematical modeling and the life sciences – creating a novel toolkit for microrobotics
This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges.
Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering
This book introduces interesting topics, from concepts to the latest research, on cellular and micro robotic systems. The cellular robotic system is a self-organizing robotic system composed of a large number of autonomous robotic units, named cells. This idea came from the organic structure of a living body. Several attractive topics in this area are covered, such as swarm intelligence, communications, and robotic mechanisms. The micro robotic system is currently the most fascinating technology. Micro mechanisms, control and intelligence, with respect to this system are treated here. The combination of both technologies will prepare the way for a new paradigm in the field of engineering.