Download Free Improvements In Continuum Modeling For Biomolecular Systemsproject Supported By The National Natural Science Foundation Of China Grant No 91230106 And The Chinese Academy Of Sciences Program For Cross Cooperative Team Of The Science Technology Innovation Book in PDF and EPUB Free Download. You can read online Improvements In Continuum Modeling For Biomolecular Systemsproject Supported By The National Natural Science Foundation Of China Grant No 91230106 And The Chinese Academy Of Sciences Program For Cross Cooperative Team Of The Science Technology Innovation and write the review.

Abstract: Modeling of biomolecular systems plays an essential role in understanding biological processes, such as ionic flow across channels, protein modification or interaction, and cell signaling. The continuum model described by the Poisson– Boltzmann (PB)/Poisson–Nernst–Planck (PNP) equations has made great contributions towards simulation of these processes. However, the model has shortcomings in its commonly used form and cannot capture (or cannot accurately capture) some important physical properties of the biological systems. Considerable efforts have been made to improve the continuum model to account for discrete particle interactions and to make progress in numerical methods to provide accurate and efficient simulations. This review will summarize recent main improvements in continuum modeling for biomolecular systems, with focus on the size-modified models, the coupling of the classical density functional theory and the PNP equations, the coupling of polar and nonpolar interactions, and numerical progress.