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Implant dentistry has become a standard option for the rehabilitation of fully and partially edentulous patients. With the ever-increasing number of dentists involved in implant dentistry, it is essential to ensure that their treatment methods follow the highest standard. The ITI Treatment Guide series, a compendium of evidence-based implant-therapy techniques in daily practice, is written by renowned clinicians and provides a comprehensive overview of various therapeutic options. Using an illustrated step-by-step approach, the ITI Treatment Guide shows practitioners how to manage different clinical situations, with the emphasis on sound diagnostics, evidence-based treatment concepts, and predictable treatment outcomes. The second volume of the ITI Treatment Guide is devoted to the restoration of partially dentate patients. Central to this volume of the ITI Treatment Guide are loading protocols available to the clinician and the patient and how they relate to various treatment indications, including both single and multiple missing teeth in the posterior and anterior regions of the mouth. Among potential topics for upcoming volumes are implant placement in extraction sockets, loading protocols in edentulous patients, implant therapy in the esthetic zone in extended edentulous spaces, and many more.
The management of orthopedic infection is an area of growing importance in orthopedic surgery. This text provides a complete overview from basic research to clinical application and future perspectives in the treatment of orthopedic infection emphasizing the role of local therapy. Coverage details the various approaches to the treatment of orthopedic infections, making the book an important tool for the daily practice of its readers.
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Ideal for shoulder surgeons who want to upgrade their skills to the next level, this practical, step-by-step text presents the latest cutting-edge management strategies and science aimed at shoulder preservation surgery. Highlighting four main areas - the overhead athlete, shoulder instability, glenohumeral arthritis, and the rotator cuff - these innovative techniques focus on the maintenance of the native shoulder joint. Chapters open with an introduction to the clinical problem, followed by misgivings related to open surgery or arthroplasty as treatment strategies. A rationale for the arthroscopic treatment is then presented, along with an in-depth description of the technique itself as well as preliminary results. Techniques presented include posterior capsule release for the overhead athlete, arthroscopic Latarjet for instability, the CAM procedure for glenohumeral arthritis, biological augmentation for rotator cuff repair. A fifth section covers post-operative care and return-to-play considerations. With contributions from many of the top thinkers and surgeons of the shoulder, Elite Techniques in Shoulder Arthroscopy brings these exciting new management strategies to the fore with the aim of elevating them to more common practice for orthopedic surgeons and sports medicine specialists.
Treatment protocols involving placement of dental implants require a dental team with expertise in surgery, restoration, and laboratory procedures. However, the responsibility for coordinating the treatment plan falls to the restorative clinician who must develop the blueprint for restoration. This concise and easy-to-follow guide provides a basic understanding of the fundamental principles of implant dentistry and prepares a clinician to lead the treatment team through the stages of restoration to produce an esthetic and functional result. The first part provides an overview of implants and their components, an explanation of the theory of osseointegration, and a guide to patient diagnosis and treatment planning, including strategies on how to interact with surgical colleagues and laboratory technicians. The second part consists of effective clinical protocols for simple implant restoration using techniques that are currently available and commonly used. This book is an ideal starting point for students and practitioners new to implant dentistry.
This valuable reference presents a considerable body of materials knowledge distilled from the leading industrial institutions' practical experience in developing and improving threaded fasteners, introducing engineers to the selection, procurement and quality control of fasteners. It gives elementary design formulas for fastener sizing, properties and sample calculations. Illustrated with tables and drawings, this volume is an important reference for any mechancial, design, manufacturing, automotive and aerospace engineers, technologists and technicians; fastener manufacturers and sales personnel, under graduate-level coureses in manufacturing and mechanical engineering and industry in-house training courses in fastener design and manufacture.
This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines. The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book’s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies’ efforts to address them.
Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Sample Chapter(s). Chapter 1: Introduction. Nanocarriers for Drug Delivery: Needs and Requirements (442 KB). Contents: Nanoparticle Flow: Implications for Drug Delivery (A T Florence); Polymer Micelles as Drug Carriers (E V Batrakova et al.); Lipoproteins as Pharmaceutical Carriers (S Liu et al.); Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia); Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero); Magnetic Nanoparticles as Drug Carriers (U O Hnfeli & M Chastellain); Liposomal Drug Carriers in Cancer Therapy (A A Gabizon); Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw); Nanoparticles for Targeting Lymphatics (W Phillips); Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso); and other papers. Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging."
In the past few years spine surgery has undergone revolutionary changes leading towards minimally invasive techniques. This book is a survey of microsurgical as well as endoscopic surgical techniques for the treatment of a variety of spinal disorders. The structure of the individual chapters includes terminology, history, surgical principles, advantages/disadvantages, indications, surgical technique, complications and hazards as well as results. However all chapters are focused on a very didactic presentation of surgical steps. Thus, the reader will get familiar with a variety of new techniques some of which are already integrated into clinical routine others still being part of ongoing clinical trials and development.