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Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. Immunopharmacology of Respiratory System embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance. - Focuses on aspects of disease pathogenesis that are common to a variety of lung disorders - Includes coverage of the mechanisms of asthma - origin, progression, and novel therapeutic interventions - This volume is another in the "Systems" section of the Handbook of Immunopharmacology
The second edition of this text has been revised and refocused to reflect the transformation of immunotoxicology from a subdiscipline of toxicology to an independent area of research that can best be described as "environmental immunology." New chapters discuss the role of immune mediators in liver, lung, and skin toxicity, in regulating chemical- metabolizing enzymes, and in the immunosuppression produced by ultraviolet light. More emphasis is placed on the clinical consequences of immunotoxicity, as well as the interpretation of experimental data for predicting, human health risk.; The second edition is divided into three major sections: immunosuppression, autoimmunity, and hypersensitivity. This new organization of the text allows for a more thorough treatment of these phenomena, with greater attention to test methods, theoretical considerations, and clinical implications. The book includes many chapters on specific environmental agents, therapeutic drugs, biological agents, and drugs of abuse, as well as on immune-mediated toxicity in specific organ systems.
Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are detailed. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.​
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. - Explores the current state of Alzheimer's disease research and therapeutics - Chapters cover a variety of topics such as the B cell targeted therapies, lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin - With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike
First multi-year cumulation covers six years: 1965-70.
Advances in Pharmacology, Volume 91, the latest release in this well-received series, presents the latest information in the field, with this update including chapters on Modulation of inflammation and immune response by the stress-activated transcription factor Nrf2, Therapeutic modulation of macrophage phenotype to treat acute and chronic liver diseases, Immodulation by cannabinoids, The use of nanomaterials to target immunity, Next generation in cancer immunotherapy, checkpoint inhibitors, Vaccines as a therapy for food allergy, Role of inflammation/immune system in depression, Therapeutic targeting of tumor-associated macrophages, Mast cells, and more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
The realisation that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology. This volume adopts a step-by-step approach, whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive but integrated treatise of epithelial function and its immunopharmacology, which aims to serve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immunopharmacology as they are currently understood.