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Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.
"Proceedings A publishes refereed research papers in the mathematical, physical, and engineering sciences. The emphasis is on new, emerging areas of interdisciplinary and multidisciplinary research." Continues: Proceedings. Mathematical and physical sciences.
This is volume 1 of a 2-volume set. Marine Design XIII collects the contributions to the 13th International Marine Design Conference (IMDC 2018, Espoo, Finland, 10-14 June 2018). The aim of this IMDC series of conferences is to promote all aspects of marine design as an engineering discipline. The focus is on key design challenges and opportunities in the area of current maritime technologies and markets, with special emphasis on: • Challenges in merging ship design and marine applications of experience-based industrial design • Digitalisation as technological enabler for stronger link between efficient design, operations and maintenance in future • Emerging technologies and their impact on future designs • Cruise ship and icebreaker designs including fleet compositions to meet new market demands To reflect on the conference focus, Marine Design XIII covers the following research topic series: •State of art ship design principles - education, design methodology, structural design, hydrodynamic design; •Cutting edge ship designs and operations - ship concept design, risk and safety, arctic design, autonomous ships; •Energy efficiency and propulsions - energy efficiency, hull form design, propulsion equipment design; •Wider marine designs and practices - navy ships, offshore and wind farms and production. Marine Design XIII contains 2 state-of-the-art reports on design methodologies and cruise ships design, and 4 keynote papers on new directions for vessel design practices and tools, digital maritime traffic, naval ship designs, and new tanker design for arctic. Marine Design XIII will be of interest to academics and professionals in maritime technologies and marine design.
Marine Design XIII collects the contributions to the 13th International Marine Design Conference (IMDC 2018, Espoo, Finland, 10-14 June 2018). The aim of this IMDC series of conferences is to promote all aspects of marine design as an engineering discipline. The focus is on key design challenges and opportunities in the area of current maritime technologies and markets, with special emphasis on: • Challenges in merging ship design and marine applications of experience-based industrial design • Digitalisation as technological enabler for stronger link between efficient design, operations and maintenance in future • Emerging technologies and their impact on future designs • Cruise ship and icebreaker designs including fleet compositions to meet new market demands To reflect on the conference focus, Marine Design XIII covers the following research topic series: •State of art ship design principles - education, design methodology, structural design, hydrodynamic design; •Cutting edge ship designs and operations - ship concept design, risk and safety, arctic design, autonomous ships; •Energy efficiency and propulsions - energy efficiency, hull form design, propulsion equipment design; •Wider marine designs and practices - navy ships, offshore and wind farms and production. Marine Design XIII contains 2 state-of-the-art reports on design methodologies and cruise ships design, and 4 keynote papers on new directions for vessel design practices and tools, digital maritime traffic, naval ship designs, and new tanker design for arctic. Marine Design XIII will be of interest to academics and professionals in maritime technologies and marine design.
This book deals with ship design and in particular with methodologies of the preliminary design of ships. The book is complemented by a basic bibliography and five appendices with useful updated charts for the selection of the main dimensions and other basic characteristics of different types of ships (Appendix A), the determination of hull form from the data of systematic hull form series (Appendix B), the detailed description of the relational method for the preliminary estimation of ship weights (Appendix C), a brief review of the historical evolution of shipbuilding science and technology from the prehistoric era to date (Appendix D) and finally a historical review of regulatory developments of ship's damage stability to date (Appendix E). The book can be used as textbook for ship design courses or as additional reading for university or college students of naval architecture courses and related disciplines; it may also serve as a reference book for naval architects, practicing engineers of related disciplines and ship officers, who like to enter the ship design field systematically or to use practical methodologies for the estimation of ship's main dimensions and of other ship main properties and elements of ship design.