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This book illustrates the characteristics of imaging after treatment in brain gliomas. It describes in detail the modifications to brain tissue, both healthy and pathological, that can manifest after surgery, radiotherapy or chemotherapy treatment. These modifications are discussed in terms of both how they occur in the immediate post-treatment period, and in the long term. The imaging methods used include CT with and without the addition of contrast medium, but above all MRI, which involves the use of routine basic sequences and mainly advanced study techniques such as diffusion, perfusion, spectroscopy and cortical activation. The aim of the text is to equip neuroradiologists with adequate expertise in post-treatment examinations reporting, allowing them to perform an effective differential diagnosis between the persistency or recurrence of illness and the effects of short or long-term treatment. The book is divided into a general section, which addresses the classification of cerebral tumors, the surgical treatment options, radiotherapy and chemotherapy protocols; and a section on clinical cases that employs rich iconography, making it quick and easy to consult. This second edition has been updated to reflect the new WHO classification system from 2016; new surgical, radiotherapy and chemotherapeutic treatment options; and (in the iconography section) the new sequences available from the manufacturers of RM scanners.
This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy and chemotherapy. It features more than 40 clinical cases and 500 illustrations, making it an invaluable clinical and research tool.
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice. The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn: current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits
Provides a summary of glioma biology, genetics and management, based on the world-leading Duke University Preston Robert Tisch Brain Tumor Center program.
Treatment of malignant glioma remains a major challenge for neurosurgeons, neurologists, medical oncologists, and radiation oncologists caring for patients with these tumors. Glioblastoma multiforme, the most common type of brain tumor, is also the most deadly -- only five percent of patients or fewer will be alive at five years after diagnosis. This comprehensive new reference is edited by a renowned team consisting of a neurosurgeon, medical oncologist, oncologic surgeon, and radiation oncologist. The book provides basic researchers and clinicians with a contemporary review of the epidemiology, diagnosis, and treatment of glioblastoma multiforme, and also imparts to experienced investigators outside of the field sufficient background to apply their skills to the treatment of this deadly disease. Expert malignant glioma researchers and clinicians provide state-of-the-art chapters on important topics such as molecular genetic classification of glioblastoma, surgical management, stem cell therapy, chemotherapy, angiogenesis, and more.
This book reviews the significant advances in our understanding of glioma biology that have been achieved during the past decade and describes in detail the resultant new approaches to treatment. Improvements in surgical techniques, radiation therapy, and chemotherapy are comprehensively covered, with discussion of their impact in decreasing patient morbidity and increasing survival. In addition, individual chapters are devoted specifically to current treatment for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. Other topics addressed include treatment of the elderly patient, investigating emerging therapies from small molecules to immunotherapy and palliative care. This timely book will be a valuable source of up-to-date information for practitioners and will also be of interest to researchers.
New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients. Provides the first comprehensive book to discuss techniques for removing gliomas that are traditionally deemed ‘inoperable’ Presents a great reference tool that challenges stereotypical thinking by offering techniques by innovative surgeons Includes chapters that are organized by different glioma types and surgery/techniques
Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation