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This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
This rare interdisciplinary combination of research into neighbourhood dynamics and effects attempts to unravel the complex relationship between disadvantaged neighbourhoods and the life outcomes of the residents who live therein. It seeks to overcome the notorious difficulties of establishing an empirical causal relationship between living in a disadvantaged area and the poorer health and well-being often found in such places. There remains a widespread belief in neighbourhood effects: that living in a poorer area can adversely affect residents’ life chances. These chapters caution that neighbourhood effects cannot be fully understood without a profound understanding of the changes to, and selective mobility into and out of, these areas. Featuring fresh research findings from a number of countries and data sources, including from the UK, Australia, Sweden and the USA, this book offers fresh perspectives on neighbourhood choice and dynamics, as well as new material for social scientists, geographers and policy makers alike. It enriches neighbourhood effects research with insights from the closely related, but currently largely separate, literature on neighbourhood dynamics.
Structuring, or, as it is referred to in the title of this book, the art of structuring, is one of the core elements in the discipline of Information Systems. While the world is becoming increasingly complex, and a growing number of disciplines are evolving to help make it a better place, structure is what is needed in order to understand and combine the various perspectives and approaches involved. Structure is the essential component that allows us to bridge the gaps between these different worlds, and offers a medium for communication and exchange. The contributions in this book build these bridges, which are vital in order to communicate between different worlds of thought and methodology – be it between Information Systems (IS) research and practice, or between IS research and other research disciplines. They describe how structuring can be and should be done so as to foster communication and collaboration. The topics covered reflect various layers of structure that can serve as bridges: models, processes, data, organizations, and technologies. In turn, these aspects are complemented by visionary outlooks on how structure influences the field.
The two-volume set of LNCS 11778 and 11779 constitutes the refereed proceedings of the 18th International Semantic Web Conference, ISWC 2019, held in Auckland, New Zealand, in October 2019. The ISWC conference is the premier international forum for the Semantic Web / Linked Data Community. The total of 74 full papers included in this volume was selected from 283 submissions. The conference is organized in three tracks: for the Research Track 42 full papers were selected from 194 submissions; the Resource Track contains 21 full papers, selected from 64 submissions; and the In-Use Track features 11 full papers which were selected from 25 submissions to this track.
This book comprises select peer-reviewed papers presented at the International Conference on Advanced Engineering Optimization Through Intelligent Techniques (AEOTIT) 2018. The book combines contributions from academics and industry professionals, and covers advanced optimization techniques across all major engineering disciplines like mechanical, manufacturing, civil, automobile, electrical, chemical, computer and electronics engineering. Different optimization techniques and algorithms such as genetic algorithm (GA), differential evolution (DE), simulated annealing (SA), particle swarm optimization (PSO), artificial bee colony (ABC) algorithm, artificial immune algorithm (AIA), teaching-learning-based optimization (TLBO) algorithm and many other latest meta-heuristic techniques and their applications are discussed. This book will serve as a valuable reference for students, researchers and practitioners and help them in solving a wide range of optimization problems.
Military robots are affecting both the decision to go to war and the means by which wars are conducted. This book covers the history of military robotics, analyzes their current employment, and examines the ramifications of their future utilization. Robotic systems are the future of military conflicts: their development is already revolutionizing the nature of human conflict-and eroding the standards of acceptable behavior in wartime. Written by a professor who teaches strategy and leadership for the U.S. Air Force, one of the global leaders in the development and utilization of military robots, this book both addresses the history of military robotics and discusses the troubling future ramifications of this game-changing technology. Organized both chronologically and thematically, the book's chapters describe the development and evolution of unmanned warfare; clarify the past, current, and future capabilities of military robotics; and offer a detailed and convincing argument that limits should be placed upon their development before it is too late. This standout work presents an eye-opening analysis that military personnel, civil servants, and academic instructors who teach military history, social policy, and ethics can ill afford to ignore, and will also provide the general public with information that will correct misconceptions about military robotics derived through popular culture and the news media.