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Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applications This book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational challenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest work in leading labs actively contributing to the fast-growing field of NGS. The book is divided into four parts: Part I focuses on computing and experimental infrastructure for NGS analysis, including chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling strategies for massive viral sequencing, and high-fidelity sequencing protocols. Part II concentrates on analysis of DNA sequencing data, covering the classic scaffolding problem, detection of genomic variants, including insertions and deletions, and analysis of DNA methylation sequencing data. Part III is devoted to analysis of RNA-seq data. This part discusses algorithms and compares software tools for transcriptome assembly along with methods for detection of alternative splicing and tools for transcriptome quantification and differential expression analysis. Part IV explores computational tools for NGS applications in microbiomics, including a discussion on error correction of NGS reads from viral populations, methods for viral quasispecies reconstruction, and a survey of state-of-the-art methods and future trends in microbiome analysis. Computational Methods for Next Generation Sequencing Data Analysis: Reviews computational techniques such as new combinatorial optimization methods, data structures, high performance computing, machine learning, and inference algorithms Discusses the mathematical and computational challenges in NGS technologies Covers NGS error correction, de novo genome transcriptome assembly, variant detection from NGS reads, and more This text is a reference for biomedical professionals interested in expanding their knowledge of computational techniques for NGS data analysis. The book is also useful for graduate and post-graduate students in bioinformatics.
This is the proceedings of the Fourth Workshop on Computing: Theory and Practice, WCTP 2015 devoted to theoretical and practical approaches to computation. This workshop was organized by four top universities in Japan and the Philippines: Tokyo Institute of Technology, Osaka University, University of the Philippines - Diliman, and De La Salle University. The proceedings provides a view of the current movement in research in these two countries. The papers included in the proceedings focus on the two research areas: theoretical and practical aspects of computation.
This volume contains 68 papers presented at SCI 2016: First International Conference on Smart Computing and Informatics. The conference was held during 3-4 March 2017, Visakhapatnam, India and organized communally by ANITS, Visakhapatnam and supported technically by CSI Division V – Education and Research and PRF, Vizag. This volume contains papers mainly focused on smart computing for cloud storage, data mining and software analysis, and image processing.
This two-volume set (CCIS 905 and CCIS 906) constitutes the refereed proceedings of the Second International Conference on Advances in Computing and Data Sciences, ICACDS 2018, held in Dehradun, India, in April 2018. The 110 full papers were carefully reviewed and selected from 598 submissions. The papers are centered around topics like advanced computing, data sciences, distributed systems organizing principles, development frameworks and environments, software verification and validation, computational complexity and cryptography, machine learning theory, database theory, probabilistic representations.
This book constitutes the proceedings of the 12th International Symposium on Bioinformatics Research and Applications, ISBRA 2016, held in Minsk, Belarus, in June 2016. The 25 papers presented in this volume were carefully reviewed and selected from 77 submissions. They were organized in topical sections named: next generation sequencing data analysis; protein-protein interactions and networks; protein and RNA structure; phylogenetics; sequence analysis; and statistical methods.
This book presents a collection of state-of-the-art approaches for deep-learning-based biomedical and health-related applications. The aim of healthcare informatics is to ensure high-quality, efficient health care, and better treatment and quality of life by efficiently analyzing abundant biomedical and healthcare data, including patient data and electronic health records (EHRs), as well as lifestyle problems. In the past, it was common to have a domain expert to develop a model for biomedical or health care applications; however, recent advances in the representation of learning algorithms (deep learning techniques) make it possible to automatically recognize the patterns and represent the given data for the development of such model. This book allows new researchers and practitioners working in the field to quickly understand the best-performing methods. It also enables them to compare different approaches and carry forward their research in an important area that has a direct impact on improving the human life and health. It is intended for researchers, academics, industry professionals, and those at technical institutes and R&D organizations, as well as students working in the fields of machine learning, deep learning, biomedical engineering, health informatics, and related fields.