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In this New York Times bestselling “imperative how-to for creativity” (Nick Offerman), Adam Savage—star of Discovery Channel’s Mythbusters—shares his golden rules of creativity, from finding inspiration to following through and successfully making your idea a reality. Every Tool’s a Hammer is a chronicle of my life as a maker. It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and break­ing, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the fric­tion in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
The e-mail Danny and Allison read on their new computer in 1996 looks no different from the millions of others received by Web users around the world, with one glaring exception--it was sent by their dads who died during the 1970s. While residing in the afterworld at an amenity-laden paradise called Midway Manor, guitar-strumming Mickey Parks and piano-playing Lloyd Wallace monitor and manipulate the lives of their adult children on earth from the mid-'70s through the 1990s. Tampering with the facility's sophisticated computer, the dads thrust Mickey's daughter Allison and Lloyd's son Danny into a passionate but sometimes stormy relationship-a relationship steeped in Danny's heavy drinking and entangled in the often-zany world of men's adventure magazine publishing. After carefully implementing a plan to send their son and daughter a gift of knowledge that could enrich their lives forever, the dads' brief contact is cut short. They are banished to another destination in the afterworld, but not before they impart indisputable proof of life after death--and unwittingly put Danny's and Allison's earthbound lives on the line.
Provides students with a foundation of knowledge they can build on as they pursue a career in healthcare. This work is written in a user-friendly style.
Corresponding chapter-by-chapter to Medical-Surgical Nursing, 9e, Elsevier Adaptive Learning combines the power of brain science with sophisticated, patented Cerego algorithms to help you learn faster and remember longer. It's fun; it's engaging; and it's constantly tracking your performance and adapting to deliver content precisely when it's needed to ensure core information is transformed into lasting knowledge. Please refer to the individual product pages for the duration of access to these products. An individual study schedule reduces cognitive workload and helps you become a more effective learner by automatically guiding the learning and review process. The mobile app offers a seamless learning experience between your smartphone and the web with your memory profile maintained and managed in the cloud. UNIQUE! Your memory strength is profiled at the course, chapter, and item level to identify personal learning and forgetting patterns. UNIQUE! Material is re-presented just before you would naturally forget it to counteract memory decay. A personalized learning pathway is established based on your learning profile, memory map, and time required to demonstrate information mastery. The comprehensive student dashboard allows you to view your personal learning progress.
A riveting new science fiction novel from the writer who twice won the Philip K. Dick Award for best SF novel.Bela and Paul, two wild young mathematicians, are friends and roommates, and in love with the same woman, who happens to be Alma, Bela's girlfriend. They fight it out by changing reality using cutting edge math, to change who gets the girl. The contemporary world they live in is not quite this one, but much like Berkeley, California, and the two graduate students are trying to finish their degrees and get jobs. It doesn't help that their unpredictable advisor Roland is a mad mathematical genius who has figured out a way to predict isolated and specific bits of the future that can cause a lot of trouble. . .and he's starting to see monsters in mirrors. Bela and Paul start to mess around with reality, and when that happens, all heaven and hell break loose. Those monsters of Roland's were really there, but who are they? This novel is a romantic comedy with a whole corkscrew of SF twists. At the publisher's request, this title is being sold without Digital Rights Management software (DRM) applied.
The book covers basic theories, basic knowledge and basic skills on clinical diagnosis, basic requirements for doctors’ ethical conduct, clinical reasoning and documentation of medical records during the process of making a diagnosis. It consists of six parts, including ‘Symptoms’, ‘History Taking’, ‘Physical Examination’, ‘Supplementary Examination’, ‘Common Clinical Diagnosis Techniques’, and ‘Diagnostic Process and Clinical Reasoning’. A vocabulary index is included for easy reference at the end of the book. This book is compiled by authors of 14 Chinese medical schools and universities, whose years of experience in clinical diagnostics, rich overseas learning and working experiences. This book is included in the first round of English textbooks series for clinical medicine major of China's higher medical colleges; and is among "13th Five-Year" planning textbooks of National Health Commission of the People’s Republic of China. It is also an ideal textbook for MBBS (Bachelor of Medicine and Bachelor of Surgery) student It is a co-publication book with People's Medical Publishing House (PMPH). The ISBN of PMPH version in China is 978-7-117-23852-6.
The innovative case-based way to learn neurology – completely revised for today’s shelf exam Medical students need exposure to cases to pass the USMLE® and shelf exams, and this is exactly what Case Files: Neurology, Third Edition offers. Written by experienced educators, it teaches students how to think through diagnosis and management when confronting neurological clinical problems. Sixty high-yield clinical cases focus on the core competencies for the neurology clerkship. Each case includes extended discussion, definition of key terms, clinical pearls, and USMLE-style review questions. This interactive learning system helps students learn instead of memorize. The Third Edition has been completely revised with new questions, enhanced discussions, and better alignment with the challenging shelf exam to give students an unmatched review and learning tool. • Clinical pearls highlight key points • Reflects the most recent clerkship guidelines and core curriculum • Helps students learn in the context of real patients
Exhaustively illustrated in color with over 1000 photographs, figures, histopathology slides, and sonographs, this uniquely authoritative atlas provides the clinician with a visual guide to diagnosing congenital anomalies, both common and rare, in every organ system in the human fetus. It covers the full range of embryo and fetal pathology, from point of death, autopsy and ultrasound, through specific syndromes, intrauterine problems, organ and system defects to multiple births and conjoined twins. Gross pathologic findings are correlated with sonographic features in order that the reader may confirm visually the diagnosis of congenital abnormalities for all organ systems. Obstetricians, perinatologists, neonatologists, geneticists, anatomic pathologists, and all practitioners of maternal-fetal medicine will find this atlas an invaluable resource.