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Infertility is a widespread condition with significant consequences on both individual and societal levels. It has a prevalence of 9-18% of the general population, a rate that is seen in similar levels in different countries and continents. While significant progress has already been made in understanding the etiologies, pathogenesis, and management of a variety of conditions that can affect both male and female infertility at various levels, infertility remains a challenging problem for physicians and society. Even in advanced centers, the success rate of infertility treatments lingers at about 60%, and we believe that with more research we can tackle the most difficult situations. Although our understanding of embryo development and selection has greatly improved, knowledge of uterine and endometrial function and dysfunction is still insufficient. We welcome basic and translational research contributions that focus on the advancement of the field of uterine and endometrial physiology and pathology, aiming to address current challenges and unsolved issues. We welcome basic and translational studies on diagnosis and potential therapeutic management of a variety of issues affecting female reproduction at the level of the uterus, such as but not limited to: • endometriosis and adenomyosis, • immunology of endometrium, • endometritis, • implantation failure, • unexplained infertility, • studies on endometrial function/dysfunction, endometrial receptivity, uterine microbiota; • studies that focus on possible implementation and advancement of personalized medicine in management of uterine disorders of reproduction.
Frontiers in Tissue Engineering is a carefully edited compilation of state-of-the-art contributions from an international authorship of experts in the diverse subjects that make up tissue engineering. A broad representation of the medical, scientific, industrial and regulatory community is detailed in the book. The work is an authoritative and comprehensive reference source for scientists and clinicians working in this emerging field. The book is divided into three parts: fundamentals and methods of tissue engineering, tissue engineering applied to specialised tissues, and tissue engineering applied to organs. The text offers many novel approaches, including a detailed coverage of cell-tissue interactions at cellular and molecular levels; cell-tissue surface, biochemical, and mechanical environments; biomaterials; engineering design; tissue-organ function; new approaches to tissue-organ regeneration and replacement of function; ethical considerations of tissue engineering; and government regulation of tissue-engineered products.
The first medical specialty selection guide written by residents for students! Provides an inside look at the issues surrounding medical specialty selection, blending first-hand knowledge with useful facts and statistics, such as salary information, employment data, and match statistics. Focuses on all the major specialties and features firsthand portrayals of each by current residents. Also includes a guide to personality characteristics that are predominate with practitioners of each specialty. “A terrific mixture of objective information as well as factual data make this book an easy, informative, and interesting read.” --Review from a 4th year Medical Student
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.
Research on small groups played an important role in the early formulation of social psychology. By the 1970s, however, the field had lost the interest of most social psychologists. Theory and Research on Small Groups reintegrates that work back into the mainstream of social psychology. The more recent `issues-oriented' approach has not only resulted in many interesting findings-it has also applied basic social psychological theory in new ways and, moreover, led to new theoretical developments that deserve more attention. This volume, which features the work of esteemed researchers from around the world, is a bountiful resource worthy of notice by all social psychologists.
The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.