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The combination of two leading imaging techniques – magnetic resonance imaging and positron emission tomography – is poised to have a large impact and has recently been a driver of research and clinical applications. The hybrid instrument is capable of acquiring both datasets simultaneously and this affords a number of advantages ranging from the obvious, two datasets acquired in the time required for one, through to novel applications. This book describes the basics of MRI and PET and then the technical issues and advantages involved in bringing together the two techniques. Novel applications in preclinical settings, human imaging and tracers are described. The book is for students and scientists entering the field of MR–PET with an MRI background but lacking PET or vice versa. It provides practical details from experts working in the area.
This book serves as a reference and comprehensive guide for PET/MR neuroimaging. The field of PET/MR is rapidly evolving, however, there is no standard resource summarizing the vast information and its potential applications. This book will guide neurological molecular imaging applications in both clinical practice and the research setting. Experts from multiple disciplines, including radiologists, researchers, and physicists, have collaborated to bring their knowledge and expertise together. Sections begin by covering general considerations, including public health and economic implications, the physics of PET/MR systems, an overview of hot lab and cyclotron, and radiotracers used in neurologic PET/MRI. There is then coverage of each major disease/systemic category, including dementia and neurodegenerative disease, epilepsy localization, brain tumors, inflammatory and infectious CNS disorders, head and neck imaging, as well as vascular hybrid imaging. Together, we have created a thorough, concise and up-to-date textbook in a unique, user-friendly format. This is an ideal guide for neuroradiologists, nuclear medicine specialists, medical physicists, clinical trainees and researchers.
This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.
Practical and clinically oriented, the third edition of Clinical Molecular Anatomic Imaging focuses on PET/CT, SPECT/CT, and PET/MR examinations – precisely the information you need to know. Ideal for clinical hybrid imaging users, it fully integrates all applications, allowing you to easily compare modalities and decide whether to use PET/CT, PET/MR, or SPECT/CT to solve a clinical dilemma. More than 1,600 high-quality illustrations document the use of integrated imaging and provide superb visual references for interpreting integrated imaging studies.
This clinically oriented book provides an up-to-date review on the various hybrid imaging modalities that may be employed for the purpose of cardiac imaging. After discussion of generic aspects of hybrid imaging, SPECT/CT, PET/CT, and PET/MRI are each considered in depth. In addition, information is provided on upcoming technologies, such as dedicated so-called fast cardiac cameras (CZT detector technology) and novel probes and radiotracers. A wide variety of topics are addressed, including important technological aspects, possible applications, imaging protocols, peculiarities of the available modalities, radiation exposure, and dose reduction. Last but not least, an estimation of the cost efficiency of dedicated and hybrid imaging devices in cardiology is provided and possible scenarios with respect to health care economics are envisioned. Hybrid Cardiac Imaging will be of particular value for nuclear medicine specialists, cardiologists, and radiologists and will also be of interest to medical physicists, medical technicians, and cardiothoracic surgeons. .
This timely atlas details advancements in PET/CT and SPECT/CT. Each chapter provides nuclear medicine practitioners, radiologists, oncologists, and residents with detailed information on normal anatomy of FDG PET/CT, variations and artifacts of FDG PET/CT, normal anatomy of non-FDG PET/CT, and normal anatomy of PET/CT and SPECT/CT. Coverage emphasizes anatomy to reinforce the names of organs and to support familiarization with normal and abnormal findings. The atlas has been compiled with help from experienced contributors from several top international imaging centers. Throughout the text, four-color images aid readers in proper interpretation.
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
In compiling this textbook on the exciting novel imaging modality of PET/MRI, the editors have brought together a truly international group of experts in the field. The book is divided into two parts. The first part covers methodology and equipment and includes chapters on basic molecular medicine, contrast agents, MR attenuation and validation, and quantitative MRI and PET motion correction. The second part of the book focuses on clinical applications in oncology, cardiology, and neurology. Imaging of major neoplasms is covered in a series of individual chapters. Further chapters address functional and metabolic cardiovascular examinations and major central nervous system applications such as brain tumors and dementias. This book will be of interest to all radiologists and nuclear medicine physicians who wish to learn more about the latest developments in this important emerging imaging modality and its applications.
Describes the most common imaging technologies and their diagnostic applications so that pharmacists and other health professionals, as well as imaging researchers, can understand and interpret medical imaging science This book guides pharmacists and other health professionals and researchers to understand and interpret medical imaging. Divided into two sections, it covers both fundamental principles and clinical applications. It describes the most common imaging technologies and their use to diagnose diseases. In addition, the authors introduce the emerging role of molecular imaging including PET in the diagnosis of cancer and to assess the effectiveness of cancer treatments. The book features many illustrations and discusses many patient case examples. Medical Imaging for Health Professionals: Technologies and Clinical Applications offers in-depth chapters explaining the basic principles of: X-Ray, CT, and Mammography Technology; Nuclear Medicine Imaging Technology; Radionuclide Production and Radiopharmaceuticals; Magnetic Resonance Imaging (MRI) Technology; and Ultrasound Imaging Technology. It also provides chapters written by expert radiologists in well-explained terminology discussing clinical applications including: Cardiac Imaging; Lung Imaging; Breast Imaging; Endocrine Gland Imaging; Abdominal Imaging; Genitourinary Tract Imaging; Imaging of the Head, Neck, Spine and Brain; Musculoskeletal Imaging; and Molecular Imaging with Positron Emission Tomography (PET). Teaches pharmacists, health professionals, and researchers the basics of medical imaging technology Introduces all of the customary imaging tools—X-ray, CT, ultrasound, MRI, SPECT, and PET—and describes their diagnostic applications Explains how molecular imaging aids in cancer diagnosis and in assessing the effectiveness of cancer treatments Includes many case examples of imaging applications for diagnosing common diseases Medical Imaging for Health Professionals: Technologies and Clinical Applications is an important resource for pharmacists, nurses, physiotherapists, respiratory therapists, occupational therapists, radiological or nuclear medicine technologists, health physicists, radiotherapists, as well as researchers in the imaging field.
This careful revision keeps pace with developments in the field, with new chapters on PET Metabolism, CT and MRI in the Emergency Department, Image-Guided Electrophysiology Mapping and Ablation, and Identification of Vulnerable Atherosclerotic Plaque by Radionuclide and CT techniques, plus the introduction of new contributors Udo Hoffman and Stephan Achenbach. Praised in its previous edition as a concise source of essential information, this new edition presents the most recent information in an accessible format and serves as an excellent reference source for all cardiologists, radiologists and nuclear medicine physicians.