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The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Essential textbook for all undergraduate students of neurobiology, physiology, cell biology and preclinical medicine.
This exciting, user-friendly text covers everything sports medicine and emergency clinicians need to know when encountering sports-related injuries and trauma, whether on the field or in the office. Divided into eight thematic sections, all aspects of musculoskeletal and other trauma care are described in detail, with each chapter including key points for quick reference. The opening section presents general approaches to sports-related trauma, from initial evaluation and acute management to stabilization, anesthesia and imaging. The different types of fractures and dislocations, as well as musculoskeletal healing complications, are covered in part two. The next three sections then take in-depth looks at bone and joint trauma in the upper extremity, lower extremity and axial skeleton, respectively. Soft tissue and other sports-related trauma comprise parts six and seven - from tendons, ligaments, nerves and more to chest, head and facial injuries. The final and largest section presents sports-specific injuries, covering more than 30 individual and team activities from baseball, basketball and hockey to swimming, sailing and triathalon. Throughout, copious figures, photographs and tables enhance and advance the content for a complete, well-rounded examination of the field. Comprehensive but not complex, Sports-related Fractures, Dislocations and Trauma is a practical, high-yield manual for sports medicine and emergency care specialists, primary care physicians and any other professionals caring for athletes both on the field and in the office.
In this work, the authors integrate three major basic themes of neuroscience to serve as an introduction and review of the subject.
Cellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. An all-new introduction to electrical signaling in the nervous system. Expanded coverage of synaptic transmission and synaptic plasticity. A quantitative overview of the electrical properties of cells. New detailed illustrations.