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HPV is a growing epidemic in head and neck cancer and specialists working with these diseases are provided information on shifting trends in HPV in head and neck cancers along with challenges and controversies in treating this disease. With this virus related cancer, there is a different approach to managing this patient population. Novel therapeutic treatments are actively being developed for this type of head and neck cancer. Topics include: Epidemioloygy of HPV-head and neck cancer; Clinical detection of HPV; Clinical evaluation and disease patterns of HPV-related head and neck cancers; Impact of HPV-related head and neck cancer in clinical trials; Molecular biology of HPV and head and neck cancer and targeted therapies; Transoral robotic surgery: new surgical techniques for oropharyngeal cancers; Economic impact of HPV-related cancers; Rehabilitation needs of oropharyngeal cancer patients; Psychosocial care needs of HPV-head and neck cancer patients; and a Multi-disciplinary approach to head and neck cancers.
While cancers of the oral cavity and oropharynx were overwhelming found in smokers and drinkers, a dramatic shift is occurring with a dramatic rise in the incidence of HPV-associated oropharyngeal cancers while oral cavity cancers and HPV-negative oropharyngeal cancers appear to be declining in incidence, reflecting the reduction in cigarette smoking. These trends also have implications for how Otolaryngologists prevent, diagnose, workup, treat, and follow these patients. The focus of information in this issue is on oral cavity and oropharyngeal cancer and the implications of the HPV epidemic on this disease. Amongst the medical community during this period of trying to better grasp the association of HPV with oropharyngeal cancers, there are misconceptions and a lack of knowledge of these important shifts which are addressed by Guest Editors Jeffrey Myers and Erich Sturgis of the University of Texas, MD Anderson Cancer Center. Topics include: Epidemiology- Control of a tobacco epidemic? But emergence of a HPV epidemic?; Oral cavity and Oropharyngeal Cancer Genomics; Why Otolaryngologists need to be aware of Fanconi anemia; Impact on HPV on Orpharyngeal Cancer Biology and Response to Therapy-Implications for Treatment; Oral premalignancy- The roles of early detection and chemoprevention; Evaluation and staging- Limitations despite technological breakthroughs; 7) Surgical treatment innovations; Radiotherapy- The “Particle-rs of energy, dose, and delivery method; Systemic Treatment- Its role before, during, and after definitive treatment; How to maximize functional assessment/rehabilitation; Standardizing treatment for Cancers – An approach to cancer care or crisis?; Survivorship in Oral Cancer- Competing mortalities, morbidities, and second malignancies.
A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis
This issue of Hematology/Oncology Clinics, guest edited by Dr. Glenn J. Hanna, will focus on Head and Neck Cancer. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. This issue addresses the evaluation and management of the complex head and neck cancer patient with articles focused on unique epidemiology and therapeutic principles by subsite of disease. Additional information relevant to rare head and neck malignancies is included. The issue further focuses on the evolving applications of minimally invasive surgery in oropharynx cancer and the role of immunotherapy in the management of advanced disease. Topics include: Radiologic Evaluation of the Head and Neck Cancer Patient, Robotic and Endoscopic Approaches to Head and Neck Surgery, Cancer of the Oral Cavity and Lip, Cancer of the Oropharynx and the Association with Human Papillomavirus, Cancer of the Larynx and Hypopharynx, Cancer of the Nasal Cavity and Paranasal Sinuses, Cancer of the Nasopharynx and the Association with Epstein-Barr Virus, Salivary Glands Cancers, Thyroid and Parathyroid Cancers, Cutaneous Malignancies of the Head and Neck, Managing Recurrent and Metastatic Head and Neck Cancer, and Immunotherapy for Head and Neck Cancer. - Provides in-depth, clinical reviews on head and neck cancer, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
This issue of Otolaryngologic Clinics, guest edited by Drs. James E. Saunders, Susan R. Cordes and Mark E. Zafereo, is devoted to Global Health in Otolaryngology. Articles in this outstanding issue include: Surgical Care and Otolaryngology in Global Health; Otolaryngology and the Global Burden of Disease; Health Organization and Otolaryngology; Otolaryngology in Low-Resource Settings: Practical and Ethical Considerations; Using Technology in Global Otolaryngology; Educational Resources for Global Health in Otolaryngology; Global Hearing Loss Prevention and Services; Management of Chronic Ear Disease and Otosclerosis; An Evidenced-Based Practical Approach to Pediatric Otolaryngology in the Developing World; Outcome of Head Neck Squamous Cell Cancers in Low Resource Settings: Challenges and Opportunities; Thyroid Disease Around the World; Workforce Considerations, Training and Diseases in Africa; Workforce Considerations, Training and Diseases in Latin America; Workforce Considerations, Training and Diseases in Asia/Pacific; Workforce Considerations, Training and Diseases in the Middle East; Workforce Considerations, Training and Diseases in Europe; and Overview of Otolaryngology-related Disorders in Underserved Populations, Otolaryngology Training, and Workforce Considerations in North America.
This issue of Physician Assistant Clinics, guest edited by Laura A. Kirk, MSPAS, PA-C, is devoted to Otolaryngology. Articles in this issue include: Hyperparathyroidism: Workup and Treatment; "Sinus" Headaches: Sinusitis vs. Migraine; Sudden Sensorineural Hearing Loss; ENT Manifestations of Sarcoidosis; Pediatric Otitis Media; Evaluation and Management of Adult Neck Masses; Vestibular Migraine; Pediatric Sleep Disordered Breathing; Benign Paroxysmal Positional Vertigo (BPPV); Infectious and Inflammatory Salivary Disease; Evaluation and Management of Pediatric Neck Masses: An Otolaryngology Perspective; and Indications for Cochlear Implantation.
This issue of Otolaryngologic Clinics, guest edited by Drs. Sarah K. Wise, Ashkan Monfared, and Nicole C. Schmitt is devoted to Biologics in Otolaryngology. This issue is one of six selected each year by our series consulting editor, Dr. Sujana S. Chandrasekhar. Articles in this issue include: Biologics in otolaryngology overview, Current evidence for biologic therapy in chronic rhinosinusitis with nasal polyposis, Choosing the right patient for biologic therapy in CRSwNP, Knowledge gaps and research needs for biologic therapy in rhinology practice, Mechanisms and practical use of biologic therapies for allergy and asthma indications, Immunotherapeutic strategies in head and neck cancer, Cetuximab in head and neck cancer, Anti-PD-1 immune checkpoint blockade for head and neck cancer, Advances in adoptive cell therapy for head and neck cancer, Biologics for the treatment of recurrent respiratory papillomatosis, Past and future biologics for otologic disorders, Biological treatments for Neurofibromatosis Type II and other skullbase disorders, and Biologics in treatment of autoimmune ear disorders.
This issue of Otolaryngologic Clinics, Guest Edited by Drs. Umamaheswar Duvvuri, Arun Sharma, and Erica Thaler, is devoted to Robotics in Otolaryngology. This issue is one of six selected each year by our series Consulting Editor, Sujana S. Chandrasekhar. Articles in this important issue include: Past, present and future of Robotic Surgical Systems; History and acceptance of TORS; Current indications for TORS in OP cancer; Role of TORS for workup of unknown primary SCCa; TORS and de-escalation of cancer treatment; Pediatric Applications of TORS; TORS for OSA; Robotic thyroidectomy; Robotic Neck Dissection; Robotic management of salivary glands; Robotic Ear Surgery; Robotic skull base surgery; Salvage Surgery for TORS; Complications of TORS; QOL implications after TORS for OP CA; and Cost Considerations for Robotic Surgery.
In this issue of Otolaryngologic Clinics, guest editors Drs. Karen M. Kost and Gina D. Jefferson bring their considerable expertise to the topic of Larynx Cancer. Top experts in the field cover key topics such as perioperative assessment/prehabilitation; dysplastic lesions of the larynx; radiation for early glottic cancer; surgical management of supraglottic cancer; salvage surgery; vocal rehabilitation and quality of life; swallowing function after treatment of laryngeal cancer; end-of-life care; and more. - Contains 18 relevant, practice-oriented topics including diagnostic assessment (imaging) and staging of laryngeal cancer; surgical treatment of early glottic cancer; surgical management of advanced glottic cancer; the role of robotic surgery in laryngeal cancer; reconstruction options; and more. - Provides in-depth clinical reviews on larynx cancer, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
An Update in ENT for Internists, An Issue of Medical Clinics of North America, E-Book