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Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.
In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.
This clinical casebook provides a concise, state-of-the-art review of pediatric bleeding disorders. Presented in a case-based format, each case presents a different variant of bleeding disorder, illustrates the etiology, pathology, genetics, diagnosis, and management of the disorder, and offers clinical pearls. Disorders covered include hemophilia A and B, rare factor deficiencies, von Willebrand disease, immune thrombocytopenia purpura, and platelet dysfunctions. Written by experts in the field, Pediatric Bleeding Disorders: A Clinical Casebook is a valuable resource for clinicians and practitioners treating patients with challenging coagulation issues.
First Published in 2004. Routledge is an imprint of Taylor & Francis, an informa company.
Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. - Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers - Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice - Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice - Covers case studies that highlight the practical use of genomics in the management of patients
Pain, especially chronic pain, is a major health care problem, a fact that has precipitated a recent dramatic expansion in pain-related research efforts. This revised edition of Dr Welden Bell's classic text has been updated to incorporate the latest findings from these studies, including advanced understanding of the neurophysiology and central processing of pain and the resulting changes to diagnostic, classification, and treatment guidelines. To assist clinicians in the difficult and often complicated task of managing patients suffering from oral and facial pain, this textbook provides documented information concerning pain and pain behavior so that one may better understand what pain is, how it behaves, and how it might best be managed; develops a useful classification of orofacial pain disorders; offers practical diagnostic criteria by which the different orofacial pain disorders can be identified on a clinical level; and suggests guidelines for the effective management of patients who suffer from pain in the region of the mouth and face. The concepts and techniques discussed are supplemented with case reports as well as new, full-color photographs and illustrations to help the clinician better understand orofacial pain disorders and how to treat them effectively. (EDITOR).
In this text for graduate students in various disciplines who are studying international public health, the author focuses on conditions in low- and middle-income countries, occasionally making reference to high-income countries. He suggests approaches for fostering public health, and discusses future challenges for health promotion and disease prevention around the world. The text can also be used as a reference by those working in government agencies, international health and development agencies, and NGOs.
The human eye is only capable of detecting a miniscule percentage of the electromagnetic spectrum; we call this visible light. It is this limited perception that has defined our very reality as a species. Second Sight is the story of a brilliant young scientist who develops the nano-technology to cure blindness. He could never have prepared for the betrayal and intrigue that befell him, nor could he have foreseen the hidden agendas that lay waiting in the shadows. Michael Rose's synchronistic journey into the realms of possibility would not only leave him questioning his own sanity, but the very nature of existence itself. Neither he nor his nefarious benefactors stopped to ask: if this nano-technology could enhance the function of the human eye, what else would it see?
Steve "Sneeze" Wyatt attempts to thwart his parents' plan to have him skip eighth grade, but he has bigger problems when his friends disapprove of his new list and Mrs. "Fierce" Pierce threatens to keep him from the Invention Convention.