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This invaluable book provides comprehensive coverage of contemporary serological, cellular and molecular methodologies in histocompatibility testing, and their application to human organ transplantation and transfusion. The contributors are internationally respected authorities in histocompatibility and immunogenetics, and are closely involved in the development or application of state-of-the-art technologies. The first three sections of the book are primarily intended for use as a bench manual for histocompatibility testers, immunologists and immunogeneticists; the fourth and fifth sections, on selection of donors and statistical methods, will further assist medical practitioners involved in clinical transplantation and its outcome. The final section of the book reviews the genetics and clinical relevance of minor histocompatibility antigens.
The Tenth International Histocompatibility Workshop of this work, and Fran Berman for her help in preparing component concerning T-cell recognition of HLA class the report. MaryAnn Barletta, Sally Krell, and Halina II molecules drew its strength from the hard work, Korsun provided invaluable help with a multitude of diligence, and selfless spirit of the 23 participating organizational and operational issues. Bo Dupont and laboratories. The enthusiasm and camaraderie exhib Bob Knowles provided sound advice, helpful discus ited by the participants in Princeton during November sions, and continued support. John Hansen, Jean Marc 1987 bear testimony to the caliber of the individuals Lalouel, and the other members ofthe Organizing Com involved. mittee made valuable contributions. Rosemarie Pliitke's Numerous individuals, both inside and outside of the enthusiasm, diligence, and statistical expertise were Organizing Committee, contributed significantly to the vital ingredients in this undertaking. John Klein was success of this component of the Workshop. We thank always ready to step in and assume whatever responsibil David Eckels, Adrianna Zeevi, Nancy Reinsmoen, and ity was necessary to keep the work going. Above all, I Eric Mickelson for their continued advice, encourage owe special and personal thanks to my family, whose ment, and hard work throughout this endeavor. We thank patience, support, and understanding helped to sustain Deborah Richardson for her help during the early stages me over the last 2 years."
This book presents an authoritative collection of HLA phenotyping and genotyping techniques to be used at the bench level and as a reference. It includes detailed methodologies, notes on the interpretation of tests, reference material, and appendices.
This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.
Rubin and Damjanov's latest volume of Pathology Reviews highlights the latest progress in the interface of biology and disease. Forefront techniques and experimental models that were once considered exotic or esoteric, are explored here in the context of understanding more fully the processes involved in human disease. Topics include: regulation of liver growth • contractile cells in lungs • mineral formation in bone • folate metabolism • the "riddle of the mast cell" • HLA antigens • interleukin 6 • IgA nephropathy • Goodpasture syndrome • anti-basement membrane glomerulonephropathy • molecular mechanisms of oncogenesis • molecular diagnosis of cancer • inhibition of intercellular communication in carcinogenesis • DNA repair and its pathogenetic implications • human and rat mammary tumorigenesis. Pathology Reviews • 1990 is essential reading for everyone concerned with the mechanisms of disease.
Those who have had the privilege to visit the Sistine Chapel may remember the fres co painting of Jesus curing the leper (Marcus 1, 40-45). It seems that leprosy was not only known 2000 years ago but was also recognized as an important problem. Unfortunately, little has changed since then. Although leprosy is mainly known as an "import" disease in Europe and North America, in the greater part of the world it remains the problem it has always been, one of a stigmatizing disease comparable to the modern day pestilence, namely AIDS. Who could forget Durer's etch of a leper walking with a clapper to an nounce his presence, or the heartbreaking stories of patients, especially those with lepromatous leprosy, ousted by their own families to become social outcasts forced to beg for their food. This attitude is slowly changing and with this change the name of Mahatma Ghandi will always be connected and remembered.
Publication of papers presented at the 12th International Meeting for Forensic Haemogentics Wien 1987. Topics covered included: Formal genetics, population genetics, biochemistry and serology of nearly all hereditary blood group poly- morphisms. Also several reviews of e.g. enzyme polymor- phisms; problems and aspects of the application for paternity testing; extensive articles on forensic stain information with numerous new methods and description of artifacts; polymorphisms in body fluids; quality control methods; use of biostatistics in forensic haemogentics.
Immunology has progressed in spectacular fashion in the last four decades. Studies of the response to infectious agents, transplanted organs and tumours (and the potential to manipulate that response), and the study of the immune system as a model system in molecular cell biology have yielded dramatic advances in our understanding of the mechanisms of immunity.The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein.Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective.