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Leading researchers have contributed state-of-the-art chapters to this overview of high-performance computing in biomedical research. The book includes over 30 pages of color illustrations. Some of the important topics featured in the book include the following:
This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.
Modern medicine and healthcare are highly dependent on engineering, employing instrumentation and computer systems to aid investigation, diagnosis, treatment and patient management. The significant developments in the field of computational intelligence, combined with the emergence of high-performance computing is impacting society in many ways, and the health sector is no exception. The interface of high-performance computing, computational intelligence and medical science, has seen the emergence of intelligent medical systems. These systems can provide a deeper insight into many healthcare and medical problems. They can also aid in controlling, analyzing and the management of medical applications and can provide significant improvement in the quality of life and efficacy of clinical treatment. However, the successful application of high-performance computing in medicine requires in-depth knowledge and understanding of medical systems. This book focuses on the advances and applications of high-performance computing for medical systems and provides an insight into the latest developments in the field. It will help readers to understand the high-performance computing research domain as related to intelligent medical systems, its effect on our lives and its present limitations. Part of IOP Series in Next Generation Computing.
Members of this project have studied the academic and industrial uses of High Performance Computing (HPC) and have conducted site visits at a number of Army R & D HPC user and provider sites, including the Medical Research and Materiel Command (MRMC), Edgewood Chemical Biological Center (ECBC), the Army Research Lab's Major Shared Resource Center (MSRC), the Developmental Test Command (DTC), Research, Development, and Engineering Command's (RDECOM's) Communications- Electronics Research, Development, and Engineering (RD & E) Center (CERDEC), Scalable Network Technologies, Inc., and the Director for Command, Control, Communication, Computers, Intelligence, Surveillance, and Reconnaissance (C4ISR) for Future Combat Systems (FCS) at Boeing, Huntington Beach, California. Because of the breadth of possible uses of HPC in Army R & D, our client asked us to concentrate on two HPC application areas: biotechnology and biomedicine, and modeling and simulation of the complex battlefield wireless network communication systems. We did so, and concluded that these areas are of great importance and merit focused funding and attention.
Use the GPU Successfully in Your Radiotherapy Practice With its high processing power, cost-effectiveness, and easy deployment, access, and maintenance, the graphics processing unit (GPU) has increasingly been used to tackle problems in the medical physics field, ranging from computed tomography reconstruction to Monte Carlo radiation transport simulation. Graphics Processing Unit-Based High Performance Computing in Radiation Therapy collects state-of-the-art research on GPU computing and its applications to medical physics problems in radiation therapy. Tackle Problems in Medical Imaging and Radiotherapy The book first offers an introduction to the GPU technology and its current applications in radiotherapy. Most of the remaining chapters discuss a specific application of a GPU in a key radiotherapy problem. These chapters summarize advances and present technical details and insightful discussions on the use of GPU in addressing the problems. The book also examines two real systems developed with GPU as a core component to accomplish important clinical tasks in modern radiotherapy. Translate Research Developments to Clinical Practice Written by a team of international experts in radiation oncology, biomedical imaging, computing, and physics, this book gets clinical and research physicists, graduate students, and other scientists up to date on the latest in GPU computing for radiotherapy. It encourages you to bring this novel technology to routine clinical radiotherapy practice.
"This book disseminates knowledge regarding high performance computing for medical applications and bioinformatics"--Provided by publisher.
Biomedical Diagnostics and Clinical Technologies: Applying High-Performance Cluster and Grid Computing disseminates knowledge regarding high performance computing for medical applications and bioinformatics. This critical reference source contains a valuable collection of cutting-edge research chapters for those working in the broad field of medical informatics and bioinformatics.
Silicon photonics is beginning to play an important role in driving innovations in communication and computation for an increasing number of applications, from health care and biomedical sensors to autonomous driving, datacenter networking, and security. In recent years, there has been a significant amount of effort in industry and academia to innovate, design, develop, analyze, optimize, and fabricate systems employing silicon photonics, shaping the future of not only Datacom and telecom technology but also high-performance computing and emerging computing paradigms, such as optical computing and artificial intelligence. Different from existing books in this area, Silicon Photonics for High-Performance Computing and Beyond presents a comprehensive overview of the current state-of-the-art technology and research achievements in applying silicon photonics for communication and computation. It focuses on various design, development, and integration challenges, reviews the latest advances spanning materials, devices, circuits, systems, and applications. Technical topics discussed in the book include: • Requirements and the latest advances in high-performance computing systems • Device- and system-level challenges and latest improvements to deploy silicon photonics in computing systems • Novel design solutions and design automation techniques for silicon photonic integrated circuits • Novel materials, devices, and photonic integrated circuits on silicon • Emerging computing technologies and applications based on silicon photonics Silicon Photonics for High-Performance Computing and Beyond presents a compilation of 19 outstanding contributions from academic and industry pioneers in the field. The selected contributions present insightful discussions and innovative approaches to understand current and future bottlenecks in high-performance computing systems and traditional computing platforms, and the promise of silicon photonics to address those challenges. It is ideal for researchers and engineers working in the photonics, electrical, and computer engineering industries as well as academic researchers and graduate students (M.S. and Ph.D.) in computer science and engineering, electronic and electrical engineering, applied physics, photonics, and optics.
This IBM® Redpaper publication provides an update to the original description of IBM Reference Architecture for Genomics. This paper expands the reference architecture to cover all of the major vertical areas of healthcare and life sciences industries, such as genomics, imaging, and clinical and translational research. The architecture was renamed IBM Reference Architecture for High Performance Data and AI in Healthcare and Life Sciences to reflect the fact that it incorporates key building blocks for high-performance computing (HPC) and software-defined storage, and that it supports an expanding infrastructure of leading industry partners, platforms, and frameworks. The reference architecture defines a highly flexible, scalable, and cost-effective platform for accessing, managing, storing, sharing, integrating, and analyzing big data, which can be deployed on-premises, in the cloud, or as a hybrid of the two. IT organizations can use the reference architecture as a high-level guide for overcoming data management challenges and processing bottlenecks that are frequently encountered in personalized healthcare initiatives, and in compute-intensive and data-intensive biomedical workloads. This reference architecture also provides a framework and context for modern healthcare and life sciences institutions to adopt cutting-edge technologies, such as cognitive life sciences solutions, machine learning and deep learning, Spark for analytics, and cloud computing. To illustrate these points, this paper includes case studies describing how clients and IBM Business Partners alike used the reference architecture in the deployments of demanding infrastructures for precision medicine. This publication targets technical professionals (consultants, technical support staff, IT Architects, and IT Specialists) who are responsible for providing life sciences solutions and support.