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The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work? There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. Figuring out how it all works – how your genes build your body – is a major challenge for researchers around the world. And what they're discovering is that far from genes being a fixed, deterministic blueprint, things are much more random and wobbly than anyone expected. Drawing on stories ranging from six toed cats and stickleback hips to Mickey Mouse mice and zombie genes – told by researchers working at the cutting edge of genetics – Kat Arney explores the mysteries in our genomes with clarity, flair and wit, creating a companion reader to the book of life itself.
Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck? The answer is all of these and none of them. We get cancer because we can't avoid it—it's a bug in the system of life itself. Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us. Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy. We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move. Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.
An award-winning author takes us on a mind-bending journey through the world of DNA, exploring how it encodes our genes and make us unique. What is a genetic superhero? Is all DNA important? Can genetics affect your love life, mental health, and even ability to grow a tail? How to Code a Human answers these and many other questions as it investigates all aspects of modern genetics, from the evolution of our species to inherited disease, from "junk" DNA to the molecular processes inside our cells. This fascinating guide examines what gene sequencing reveals about who we are, how we're wired, and how we repair ourselves. Featuring stunning illustrations and infographics, this insightful guide to the code of life takes us on a beautiful visual journey--and is an essential read for anyone captivated by the scope of human discovery.
Epigenetics is the most exciting field in biology today, developing our understanding of how and why we inherit certain traits, develop diseases and age, and evolve as a species. This non-fiction comic book introduces us to genetics, cell biology and the fascinating science of epigenetics, which is rapidly filling in the gaps in our knowledge, allowing us to make huge advances in medicine. We'll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.
A thrilling, fact-packed journey of discovery through the body's immune system The human body is like an exceedingly well-fortified castle, defended by billions of soldiers – some live for less than a day, others remember battles for decades, but all are essential in protecting us from disease. This hidden army is our immune system, and without it we could not survive the eternal war between our microscopic enemies and ourselves. Immune explores the incredible arsenal that lives within us – how it knows what to attack and what to defend, and how it kills everything from the common cold virus to plague bacteria. We see what happens when the immune system turns on us, and how life is impossible without its protection. We learn how diseases try to evade the immune system and exploit its vulnerabilities, and we discover how scientists are designing new drugs to harness the power of the system to fight disease. Do transplants ever reject their new bodies? What is pus? How can your body make more antibodies than there are stars in our galaxy? Why is cancer so hard for our immune system to fight? Why do flu outbreaks cause a spike in sleep disorders? Can we smell someone else's immune system, and does that help us subconsciously decide who we fall in love with? In this book, Catherine Carver answers all of these compelling questions, and many more besides. Drawing on everything from ancient Egyptian medical texts to cutting-edge medical science, Immune will take you on an adventure packed with weird and wonderful revelations about your own internal defensive system.
Highlights what we know about the pathways pursued by embryos and evolution, and stresses what we do not yet know.
Horsemeat in burgers was hard to swallow, but there are far more sinister culinary crimes afoot... Chicken eggs that haven't come from chickens, melamine in infants' milk in China, nut shells in spices – these are just some examples of the food fraud that has occurred in recent years. As our urban lifestyle takes us further and further away from our food sources, there are increasing opportunities for dishonesty, duplicity and profit-making short-cuts. Food adulteration, motivated by money, is an issue that has spanned the globe throughout human history. Whether it's a matter of making a good quality oil stretch a bit further by adding a little extra 'something' or labelling a food falsely to appeal to current consumer trends – it's all food fraud, and it costs the food industry billions of dollars each year. The price to consumers may be even higher, with some paying for these crimes with their health and, in some cases, their lives. Sorting the Beef from the Bull is a collection of food fraud tales from around the world. It explains the role of science in uncovering some of the century's biggest food scams, and explores the arms race between food forensics and fraudsters as new methods of detection spur more creative and sophisticated means of committing the crimes. This book equips us with the knowledge of what is possible in the world of food fraud and shines a light on the shady areas of our food supply system where these criminals lurk.
Death in the Afternoon is a non-fiction book written by Ernest Hemingway about the ceremony and traditions of Spanish bullfighting, published in 1932. The book provides a look at the history and what Hemingway considers the magnificence of bullfighting. It also contains a deeper contemplation on the nature of fear and courage. While essentially a guide book, there are three main sections: Hemingway's work, pictures, and a glossary of terms.
"I tore through this urgent, timely, and deeply disturbing tale.”—Andrea Bartz, New York Times bestselling author of We Were Never Here Spine-chilling and sharp, Anne Heltzel's Just Like Mother is a modern gothic from a fresh new voice in horror, and “will disturb readers to their core.” (Library Journal) A GoodReads Choice Award Finalist for Best Horror, and named one of the Best Books of 2022 by LitReactor! The last time Maeve saw her cousin was the night she escaped the cult they were raised in. For the past two decades, Maeve has worked hard to build a normal life in New York City, where she keeps everything—and everyone—at a safe distance. When Andrea suddenly reappears, Maeve regains the only true friend she’s ever had. Soon she’s spending more time at Andrea’s remote Catskills estate than in her own cramped apartment. Maeve doesn’t even mind that her cousin’s wealthy work friends clearly disapprove of her single lifestyle. After all, Andrea has made her fortune in the fertility industry—baby fever comes with the territory. The more Maeve immerses herself in Andrea’s world, the more disconnected she feels from her life back in the city; and the cousins’ increasing attachment triggers memories Maeve has fought hard to bury. But confronting the terrors of her childhood may be the only way for Maeve to transcend the nightmare still to come... "A fierce, frightening novel."—Rachel Harrison, author of Cackle At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
An entertaining and delightful collection of short stories from the No. 84 Writing Group. Each one of the 84 stories is exactly 84 words long. Enjoy!Authors in the book: Kat Arney, Keith Avenue, Wendy Bretherton, George Brooker, Cathy Clement, Sue Couves, Anthony Cowin, Jayne Curtis, Em Dehaney, Debra Frayne, Jonathan Fryer, Ros Fryer, Peter Germany, David John Griffin, Matt Hill, Paul Hiscock, Sam Jewiss, Lex H Jones, Kayleigh Manley, Ben Morton, Brenda Marlene Moss, Catriona Murfitt, Judith Northwood-Boorman, Chrissie Pountain, Sally Skeptic, Dom Sullivan, Mike Swift, Paolo Viscardi, Richard Wall, Mark Whitehouse, P Zakia