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This book is written for researchers, undergraduate students and postgraduate students, physicians and traditional medicine practitioners who develop research in the field of neurosciences, phytochemistry and ethnopharmacology or can be useful for their practice. Topics discussed include the description of depression, its biochemical causes, the targets of antidepressant drugs, animal and cell models commonly used in the research of this pathology, medicinal plants and bioactive compounds with antidepressant activity used in traditional medicine, advances in nanotechnology for drug delivery to the brain and finally the future challenges for researchers studying this pathology.
This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K, Akt, mTOR, GSK3, BDNF, and other intracellular pathways. New theories of the pathophysiology underlying major depression, such as oxidative damage, inflammation, stress and insulin resistance are then explored. Key Features: Focuses on oxidative damage, inflammation, and metabolic syndrome. Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications. These facts lead to discussion of herbs that can be used to treat major depression, as well as consideration of the scientific basis for how these herbs act. The antidepressant properties of 66 herbs are discussed, along with dosing and safety information.
Studies the effectiveness and safety of taking St. John's Wort for depression, kava for stress or anxiety, ginkgo for memory loss, or valerian for insomnia.
When Gracelyn Guyol was diagnosed in 1993 with a mild form of bipolar disorder, also known as manic depression, she was prescribed a commonly used antidepressant. Soon she developed breast cysts and benign tumors, a possible side effect of the antidepressant. She went off the drug and within two months, her tumors disappeared. Under the care of a naturopath, Guyol embarked on a quest to educate herself about the underlying genetic, hormonal, and other causes of depression and bipolar disorder. She investigated many natural therapies-including diet, vitamins, herbal treatments, and energy healing-before finding the solutions that have kept her free of depression and bipolar symptoms since 2002. Healing Depression & Bipolar Disorder Without Drugs features Gracelyn Guyol's own story and those of thirteen other people around the country who have cured their depression and bipolar disorder using only natural therapies. In-depth research and the expertise of alternative health-care professionals are included in this landmark guide for patients and caregivers seeking responsible, safe alternatives to psychiatric drugs.
Includes CD-ROM with fully searchable text and links to Medline.
A compilation of current scientific knowledge about psychoactive herbal drugs. Virtually all cultures consume drugs from psychoactive plants. Caffeine, for example, is probably the most common stimulant in the world, and many modern medicines, such as morphine and codeine, are derived from plant sources. In these cases, scientific research has revealed the composition of the plants and how they interact with the nervous system. There are also many herbal medications with reputed therapeutic value that have not yet gained acceptance into mainstream medicine, partly because there has not been enough research to support their usefulness. Instead they are regarded as "alternative medicines." This is an active research area, however, and many current studies are focusing on identifying the active components, pharmacological properties, physiological effects, and clinical efficacy of herbal medicines. This book compiles and integrates the most up-to-date information on the major psychoactive herbal medicines—that is, herbal medicines that alter mind, brain, and behavior. It focuses particularly on the effects on various areas of cognition, including attention, learning, and memory. The book covers all major classes of psychoactive drugs, including stimulants, cognitive enhancers, sedatives and anxiolytics, psychotherapeutic herbs, analgesics and anesthetic plants, hallucinogens, and cannabis.
This book presents the current clinical evidence on the efficacy of herbal and nutritional treatments for anxiety that is experienced in association with psychiatric disorders, and explains how health professionals can apply this knowledge to the benefit of patients presenting with a wide range of symptoms, including comorbid mood disorders. All chapters are written by world-leading researchers who draw on the findings of human clinical trials to provide uncompromising assessments of individual treatments, including herbal anxiolytics with sedative actions, adaptogens, cognitive anxiolytics, and nutraceuticals. Traditional treatments requiring further study – including the plant-based psychotropic Ayahuasca and other phytotherapies of potential value in the treatment of anxiety – are also reviewed. In the closing chapters, a series of helpful case studies are provided by mental health clinicians in order to illustrate how herbal and nutritional treatments can best be integrated into an overall treatment plan for individuals with a range of comorbid diagnoses. Mental health professionals, researchers, and general readers will find that the book provides an excellent review of current scientific knowledge gained from the study of herbal and nutritional treatments, together with important clinical recommendations for their use in patients experiencing clinically significant levels of anxiety.
The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef
Integrative Medicine for Depression A disease that has long plagued humankind, depression is debilitating. Despite the frequency with which they’re prescribed, drugs alone don’t always provide relief, and often have side effects that limit effectiveness. There’s new hope for treatment, as emerging evidence suggests depression can be triggered by biochemical imbalances and nutritional deficiencies. In the newly updated edition of Integrative Medicine for Depression, mental health expert Dr. James M. Greenblatt emphasizes the treatment of depression using an integrative regimen that first seeks to understand the whole person. This book offers fresh new possibilities for those who suffer from depression. Incorporating decades of research and treatment in this groundbreaking work, Dr. Greenblatt explains: ■ The biologic mechanisms that cause depression ■ Why previous treatments may have failed ■ Nutritional approaches to improve mood ■ Ways to minimize the side effects of antidepressants ■ Strategies for a personalized supplement program
This case-based approach to geriatric medicine is suitable for all health professionals and trainees who provide care for the elderly. Examples range from the healthy elderly to those with advanced cognitive or physical impairments.