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In this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopathy (HE) is a reversible syndrome in patients with advanced liver dysfunction, and is characterized by a wide spectrum of neuropsychiatric abnormalities resulting from the accumulation of neurotoxic substances in the brain. In this issue, top experts provide detailed clinical reviews devoted to the epidemiology, manifestations, and management of HE in the hopes of improving patient outcomes. - Contains 13 relevant, practice-oriented topics including clinical manifestations of HE; laboratory abnormalities of HE; pharmacologic management of HE; nontraditional treatment of HE; social impact of HE; future therapies of HE; and more. - Provides in-depth clinical reviews on hepatic encephalopathy, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems. Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.
This volume presents a concise yet comprehensive overview on all facets concerning the complications of cirrhosis. Structured in three sections, the book reviews the natural history of cirrhosis, the diagnostic and predictive tools available to assess the disease, complications, and treatment options such as liver assist devices and transplantation. Topical concerns in the management of patients with cirrhosis are also addressed, including issues pertaining to the delivery of quality care in this patient population. Written by experts in their fields, Complications of Cirrhosis: Evaluation and Management serves as a valuable resource for practitioners and physicians-in-training on the subject of cirrhosis.
In this issue of Clinics in Liver Disease, guest editor Dr. Nikolaos T. Pyrsopoulos brings his considerable expertise to the topic of Acute-on-Chronic Liver Failure. Recent studies indicate that as many as one in four patients with cirrhosis develop acute-on-chronic liver failure (ACLF) and 25% die within one month. This issue, the first devoted to this topic, provides thorough coverage of critical clinical interventions, including diagnosis, treatment, and management. It also focuses on early recognition of ACLF, which is important for the initiation of aggressive management and ultimately, saving lives. - Contains 17 practice-oriented topics including ACLF: mechanisms of disease and multisystemic involvement; the clinical spectrum and manifestations of ACLF; management of ACLF; maximizing the donor potential for patients with ACLF Listed for Liver Transplant; future approaches and therapeutic modalities for ACLF; and more. - Provides in-depth clinical reviews of acute-on-chronic liver failure, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
In this issue of Clinics in Liver Disease, guest editor Dr. Pierre M. Gholam brings his considerable expertise to the topic of Portal Hypertension and Its Complications. Portal hypertension is often one of the major complications seen in advanced liver disease. Patients can be asymptomatic for years and considered compensated. How to manage patients prior to the point of hepatic decompensation is of utmost importance, due to the impact on life expectancy and quality. The timely clinical reviews in this issue will help hepatologists manage these patients and improve outcomes. - Contains 12 relevant, practice-oriented topics including non-invasive assessment of portal hypertension; radiological and surgical treatments of portal hypertension; bleeding complications of portal hypertension; cognitive issues and portal hypertension; surgical considerations in portal hypertension; and more. - Provides in-depth clinical reviews on portal hypertension and its complications, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
In collaboration with Consulting Editor, Dr. Norman Gitlin, Guest Editors Drs. Andres Cardenas and Thomas Reiberger have created an up-to-date monograph on the complications of cirrhosis. They have secured top experts to contribute clinical review articles on the following topics: Non-invasive Detection of CSPH in cACLD; Prevention of First Decompensation in ACLD; Treatment of Acute Variceal Bleeding in 2020: When to Use TIPS; Prevention of Variceal Bleeding and Rebleeding by NSBB: A Tailored Approach; The Role of Hepatic Venous Pressure Gradient (HVPG); Measurement in the Management of Cirrhosis; Bacterial Infections in Cirrhosis as a Cause or Consequence of Decompensation; Nutrition in Chronic Liver Disease; Diagnosis and Management of Hepatic Encephalopathy; Discriminating Acute Decompensation from Acute-on-Chronic Liver; Management of Severe and Refractory Ascites; Monitoring Renal Function and Therapy of HRS patients with Cirrhosis; Coagulopathy in Cirrhosis; and Current Concepts of Cirrhotic Cardiomyopathy. Hepatologists will come away with the information they need to manage these patients.
In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.
In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
This book focuses on the critical care of the patient with acute, acute on chronic and chronic liver failure as well as the peri-operative care of the patient with liver transplantation. Each of these disease processes is unique in pathophysiological manifestations, underpinnings of physiology and treatment options. Patients with acute, chronic or acute on chronic liver failure are a growing fraction of ICU admissions. Hepatic Critical Care serves as the essential reference for both practicing intensivists at community hospitals and tertiary referral centers. This textbook is also targeted towards trainees specifically interested in taking care of patients with liver disease and liver transplantation.
In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Steven Flamm has put together another great update for the hepatology consult. Articles are submitted by expert author and in the format of the clinical review article, provide timely data for diagnosis and treatment. Specific areas addressed include the following: Management of esophageal and gastric varices; Severe thrombocytopenia in chronic liver disease and new management approaches; Pathology in chronic liver disease; Alpha 1 antitrypsin disease and chronic liver disease in adults; Evaluation of management of Budd-Chiari; HBV reactivation with immunosuppressive therapy; Homeopathic products and hepatotoxicity; New uses of TIPS; Dermatologic manifestations of chronic liver disease; Acute on chronic liver failure; Cholangiocarcinoma; Diagnosis and management of hepatic adenoma and focal nodular hyperplasia; Emerging data about the microbiome in chronic liver disease; and Acute viral hepatitis aside from HAV, HBV, and HCV. Readers will come away with the information they need to improve patient outcomes.