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Allergic diseases are rare in areas with high helminth parasite exposure and common where helminth exposure is lacking or significantly reduced, such as urban areas of developing countries and industrialized nations. To test the hypothesis that helminths protect against allergies, Dr Carsten Flohr conducted both clinical and laboratory studies at the Oxford University Clinical Research Unit in Ho Chi Minh City (Saigon), Vietnam. Dr Flohr s work has shown that gut parasites, such as hookworm and Ascaris lumbricoides, can suppress allergic skin sensitisation to environmental allergens, an effect that is probably mediated by parasite-induced anti-inflammatory cytokines, including interleukin-10. The ultimate aim is to develop allergy drugs from parasite-derived products.
The inverse correlation between allergic diseases and helminth infections has been debated for over 30 years. It was initially assumed that the underlying mechanism is an imbalance between Th1 and Th2 responses that, as a result of reduced exposure to Th1-inducing infectious pathogens, has tipped to allergic Th2 responses. It has only recently been clearly demonstrated that helminth infections have negative effects on allergic disease manifestation. This was shown to be consistent with the activity of regulatory cell populations, which control the effector mechanisms of both Th1 and Th2. In th.
A controversial, revisionist approach to autoimmune and allergic disorders considers the perspective that the human immune system has been disabled by twentieth-century hygiene and medical practices.
Infectious Diseases and Your Health has the potential to impact and improve your life, and the lives of your loved ones. Every day, nearly 40, 000 people including small children and women die of infectious diseases. Many of these innocent lives could be saved. Your journey through the pages of this book will take you to an amazing world of infectious diseases. You will learn about various infectious diseases, how they can affect your life, the problems associated with their treatment and prevention, and how to overcome these problems. Additionally, you will hear the success story of new drug research, be introduced to the hard facts, and find fascinating pictures of microorganisms and parasites. The book provides instant solutions to several of your concerns about infectious diseases, and you will learn to live a highly productive, long and healthy life. So, join thousands of readers of this book worldwide, enhance your life and the lives of your loving family, become an informed healthy citizen, and contribute to achieving the UN’s Sustainable Development Goals. Let us never forget: life and quality of life are very precious.
THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.
Humans suffer from numerous parasitic foodborne zoonoses, many of which are caused by helminths. The helminth zoonoses of concern in this book were once limited to diseases of animals, but have now become transmissible to humans. This book reviews not only the prevalence and distribution of these zoonoses, including available health and economic impact data, but highlights gaps in our knowledge that must be filled in order to assess the importance of a particular zoonosis.
This volume of the Neglected Tropical Diseases (NTD) series covers the most prevalent NTDs in Oceania. This book will discuss in detail pathology, diagnostics and control approaches of selected NTDs in the geographic region. A large part of Oceania’s population lives in poverty and therefore is at high risk for certain parasitic diseases, such as hookworm infection, lymphatic filariasis, strongyloidiasis or scabies. In addition viral infections such as dengue and new emerging viruses are of importance as major health risks for people living and traveling in this area. Each chapter focuses on one specific disease or series of related diseases, and provides in-depth insights into the topic.