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Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.
Pathophysiology of Cardiovascular Disease has been divided into four sections that focus on heart dysfunction and its associated characteristics (hypertrophy, cardiomyopathy and failure); vascular dysfunction and disease; ischemic heart disease; and novel therapeutic interventions. This volume is a compendium of different approaches to understanding cardiovascular disease and identifying the proteins, pathways and processes that impact it.
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
This state-of-the-art reference details current and effective symptom-specific strategies for the diagnosis and management of diabetic patients-emphasizing the exploration of therapeutic options available for the treatment of accelerated coronary complications associated with diabetes. Addresses the pathophysiology underlying advanced heart
Can food really take the place of medicine? While modern medicine certainly has its place and does more than its fair share of good, there is no denying that many of society’s most perilous chronic diseases are exacerbated by poor diets. Whereas infectious diseases used to cause the most number of deaths, the impact of chronic diseases now far overshadows that of infectious diseases. Diet plays a significant role in the development of a number of types of chronic disease, such as heart disease, diabetes, and certain types of cancer. This title explores the impact of dietary choices on the prevention, management, and treatment of a number of medical conditions and disease states including cardiovascular disease, diabetes and metabolic stress, critical illness, cancer, and HIV/AIDS. Conditions of the gastrointestinal tract, musculoskeletal disorders, rheumatic disease, anemia, hepatobiliary, gallbladder, pancreatic, and kidney diseases are covered in the subsequent title Diet and Disease II.
The New York Times bestselling guide to the lifesaving diet that can both prevent and help reverse the effects of heart disease Based on the groundbreaking results of his twenty-year nutritional study, Prevent and Reverse Heart Disease by Dr. Caldwell Esselstyn illustrates that a plant-based, oil-free diet can not only prevent the progression of heart disease but can also reverse its effects. Dr. Esselstyn is an internationally known surgeon, researcher and former clinician at the Cleveland Clinic and a featured expert in the acclaimed documentary Forks Over Knives. Prevent and Reverse Heart Disease has helped thousands across the country, and is the book behind Bill Clinton’s life-changing vegan diet. The proof lies in the incredible outcomes for patients who have followed Dr. Esselstyn's program, including a number of patients in his original study who had been told by their cardiologists that they had less than a year to live. Within months of starting the program, all Dr. Esselstyn’s patients began to improve dramatically, and twenty years later, they remain free of symptoms. Complete with more than 150 delicious recipes perfect for a plant-based diet, the national bestseller Prevent and Reverse Heart Disease explains the science behind the simple plan that has drastically changed the lives of heart disease patients forever. It will empower readers and give them the tools to take control of their heart health.
Heart failure has been traditionally explained as a reduction in cardiac pumping capacity, caused by problems in the blood. Till now the therapy prescribed has been symptomatic, involving the use of diuretics, muscular stimulation and blood vessel relaxants. But recent research has focussed on the circumstances leading up to heart failure, which includes abnormal hemodynamics, atherosclerosis, dietary and nutritional anomalies, obesity, immunity and other metabolic disorders. This book brings together such research in one volume, including molecular and cellular aspects of heart failure and its pathophysiology. It is a significant contribution to the understanding and prevention of heart failure, and will be welcomed by cardiologists, pharmacologists, biochemists, and all those who practice and research the subject. The contributors from around the world include Australia, Brazil, Canada, Denmark, India, and USA.
The Saccharine Disease, Conditions Caused by the Taking of Refined Carbohydrates, such as Sugar and White Flour contends that the causation of these conditions has been obscured through confusing distinctions between unnatural, refined carbohydrates and that of natural, unrefined carbohydrates like fruits and whole meal flour. The author notes that all the foregoing conditions are really the manifestations of a single master-disease—that many of the major diseases of modern societies are caused by consuming unreasonable amounts of refined carbohydrate foods. The author discusses that in the short time that man has changed his diet, evolutionary adaptation is left behind. He gives two rules to prevent and arrest all saccharine disease manifestations: Do not eat any food unless you definitely want it, and avoid eating white flour or white sugar. These two rules will prevent gastric or duodenal ulcer, diabetes, coronary disease, constipation, complications of varicose veins, hemorrhoids, E. coli infections, obesity, and some skin conditions, As a retired Surgeon-General of the Royal Navy, the author bases his assumptions on evolutionary, epidemiological, and other scientific or historical work. This book can give insights to dieticians, food researchers, nutritionists, people on diet, and general medicine practioners.
Diabetic retinopathy (DR), a common microvascular complication, has consistently been shown to be associated with an increased risk of cardiovascular disease (CVD). This book provides complete coverage of DR as a potential marker for CVD in those with diabetes. It succinctly reviews the epidemiological and pathogenic links of DR to various cardiovascular events including stroke, coronary artery disease, chronic kidney disease, heart failure, and mortality. Furthermore, it discusses the usefulness of DR in CVD risk prediction and cardiovascular safety of anti-VEGF therapy in diabetic patients. There are insights from contemporary diabetic trials that demonstrated the enhanced cardiovascular benefit of novel glucose lowering therapy. It also highlights the potential of novel retinal imaging to predict CVD and its risk factors using the state-of-the art artificial intelligence-based deep learning systems. This book will be an invaluable resource for specialists translating research findings into clinical care, including those in cardiology, endocrinology, ophthalmology, and general practitioners. IT will also be of interest to public health practitioners, researchers, graduate students, and biotech companies interested in developing retinal image-based diagnostic and prognostic tools.
Published in 1988: The enormous literature, scattered through journals devoted to physiology, biochemistry, pharmacology, ultrastructure, and clinical medicine, together with the laboratory observations of the authors, is reviewed and integrated in an effort to portray the origin, evolution, and consequences of heart dysfunction during diabetes.