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The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. For this reason, this book focuses on the principles that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles that is presented in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents. Key Features * Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy * Unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course * Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study * Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry