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This is the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology, and function. It provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs.
Platelets are tiny blood cells that help the body form clots to stop bleeding. Antiplatelet medications, such as aspirin and clopidogrel, are commonly used to thin the blood which limits clotting and reduces the risk of heart attack. This book is a comprehensive guide to blood platelets for haematologists. Beginning with discussion on platelet structure, morphology, function and physiology, the next chapters cover the role of calcium in platelet activation and calcium modulation by cyclic nucleotides. The following sections explain the pharmacology of antiplatelet drugs, antiplatelet therapies, aspirin resistance, and the association of diabetes mellitus with major platelet dysfunction. The book concludes with chapters on acute coronary problems, interaction between endothelial cells and platelets, and blood biocompatibility studies. Authored by a Minneapolis-based expert in the field, the text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to blood platelets for haematologists Extensive coverage of antiplatelet drugs and resistance Recognised author from University of Minnesota Highly illustrated with clinical photographs, diagrams and tables
A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.
Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. - First edition won Best Book in Medical Science Award from the Association of American Publishers - Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias - A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references
Advanced Cardiovascular Exercise Physiology details the effect of acute and chronic exercise training on each component of the cardiovascular system and how those components adapt to and benefit from a systematic program of exercise training.
Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.
Now in its Third Edition, this authoritative text continues to provide a comprehensive and systematic review of the biology, pathobiology, and clinical disorders of the hemostatic system. Its unique organization of the basic sciences coupled with clinical sections yields a user-friendly integrated text, and a reference tool that meets the needs of diverse investigators and clinicians of contemporary medicine for understanding the hemostatic system. New chapter topics covered in this edition include angiogenesis and vasculogenesis; hemorrhagic complications of antithrombotic therapy; interactions of coagulation and fibrinolytic proteins with the vessel wall; and less common thrombotic disorders.
In 24 contributed chapters, 37 international specialists describe the latest developments in research on snake venom including different types of venoms and toxins, actions, antidotes, and applications and summarize what is known to date on Gila monster and frog toxins. Some 70 tables provide essent