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First multi-year cumulation covers six years: 1965-70.
Aging is one of the most universal and inevitable social and sci entific challenges confronting man. The lives of all multicellular organisms begin with conception, extend through phases of development, maturity, senescence and finally end in death. Man is no exception, but has the unique feature of a complex brain. It plays an integra tive role in adaptation to the physical and social environments through reflexes, conditioning and more complex forms of learning. The brain is a repository for both inherited and acquired information. With the development of speech and the formation of symbolic language, the human brain has made it possible to transmit information cultur ally (horizontal) to other members of society, in addition to genetic (vertical) transmission to progeny. This horizontal transmission, which has reached its highest form in man, is a powerful extension of genetic transmission. The brain may provide man all that is of im portance in life. It has played a key role in the evolution of life by maintaining and extending the life span. Many mental or intellectual capacities of man reach a peak in early adulthood, remain relatively constant throughout maturity and then appear to decline during senescence. Behaviorally, there appears to be a decrease in sensory, learning and motor functions with aging in all mammalian species. As integrated adaptive control systems, the brain and neuroendocrines have been closely associated with the homeostatic adaptation to environmental challenges throughout .the life span.
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
The increase of emotional stress has disturbing effects on the neurohumoral regulation of metabolic processes, especially in relation to the cardiovascular system, and increases the changes of organisms developing atherosclerosis. This book studies the effects on the cardiovascular system (in IHD patients) caused by emotions of diverse biological q
Volume V deals with the problems of turnover in the nervous system. "Turnover" is defined in different ways, and the term is used in different contexts. It is used rather broadly in the present volume, and intentionally so. The turnover of macromolecules is only one aspect; here "turnover" in dicates the simultaneous and coordinated formation and breakdown of macromolecular species. The complexities of cerebral protein turnover are shown in a separate chapter dealing with the synthesis of proteins, in another on breakdown, and in still another on the relationship of these two (showing how the two halves of turnover are controlled). The fact that most likely the two halves of protein turnover, synthesis and breakdown, are separated spatially and the mechanisms involved are different further emphasizes the complexity of macromolecular turnover. "Turnover" is used in a different context when the turnover of a cycle is discussed; but here again a number of complex metabolic reactions have to be interrelated and controlled; some such cycles are discussed briefly in this volume, additional cycles have been discussed with metabolism, and some cycles still await elucidation or discovery.