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Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.
Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.
The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologists, immunologists, and pharmacologists will find the book invaluable.
First multi-year cumulation covers six years: 1965-70.
This is the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology, and function. It provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs.
Biotechnology is a clearly multidisciplinary field involving biochemistry, molecular biology, genetics, immunology, microbiology, pharmacology, fermentation, agriculture, to name just a few. Each of the contributing subject areas brings its own special vocabulary and nomenclature standards and considerable difficulties of communication is the result. This book summarizes the status of the terminology in the various discipline that make up biotechnology.
Comprehensive Natural Products Chemistry
The evidence that omega-3 fatty acids are essential for human development and most helpful to achieve good health throughout life is clearly documented by Dr. Joyce Nettleton in her new book Omega-3 Fatty Acids and Health. Omega 3 fatty acids are produced by the plants of the land and sea. The tissues of the body require the omega-3 fatty acids for their proper functioning just as they also need the omega-6 essential fatty acids. It is probable in man's evolutionary development that there has always been the proper balance between these two groups of essential fatty acids, but in the modern era with the provision of inexpensive vegetable oils it is possible that the pendulum for increased dietary omega-6 fatty acids in the form of linoleic acid has swung too far and the intake ofomega-3 fatty acids has actualIy declined. In particular, the 22 carbon omega 3 fatty acid, docosahexaenoic acid, which has six double bonds, is important in the membranes of brain cells, heart muscle cells, the rods and cones of the retina and spermatozoa. Docosahexaenoic acid is found only in foods such as fish and other sea life, having been synthesized by the phytoplankton of the waters. An outright deficiency of omega-3 fatty acids has led to a number of distur bances in animals and human infants such as impaired vision, abnormalities of the electroretinogram, of the eye and various behavioral aberrations.
"Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text."--Provided by publisher.