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This volume is the second in the planned coverage of the neurochemical circuitry of the primate central nervous system. While this volume contains only two chapters, their topics and the extraordinarily comprehensive coverage with which the authors have dealt with their topics, will nevertheless contribute equal amounts of knowledge, wisdom, and opportunities for future research extensions as have every volume in this unique series. As such, these chapters extend the goals of this primate series to develop a broad coverage of human and non-human primate chemical neuroanatomic details in a volume which makes clear the known and desirable appreciation for differences between and among subsets of primate brains.The first chapter covers the primate thalamus with equal emphases on new world, old world, pro-simian and human anatomic details and their differences. The second undertakes a comparably comprehensive examination of one of the most intensively studied regions of the primate brain, namely the primate visual cortex. While much has been studied, both chapters also reveal how much remains for future efforts in these enormously important regions which are the archetypes of primate sub-cortical and cortical function.
This volume is the third and final part of the planned coverage of the neurochemical circuitry of the primate central nervous system. The five chapters included in this volume complement and integrate magnificently with the two prior volumes. Included in the volume are the following: a two-fold exposition on the human forebrain, comprised of a comprehensive overview of the entire human forebrain, and a specific focus on the basal forebrain (a region critical for a wide range of human problems ranging from substance abuse to Alzheimer's disease), a critical synthesis of the primate basal ganglia (a region under intense scrutiny for the organization of motor programs, and for their dysfunctions in Parkinson's disease, Huntington's disease and other malfunctions), the chemical and anatomic details of the primate hippocampal formation in extenso, and lastly, a review of the rapidly growing literature on the mesocortical projection of dopaminergic circuits onto the primate frontal cortex ( a system highly linked to higher order mental abstractions, as well as the dysfunctions of schizophrenia). Scholars will recognize that the laying out of these status reports on our still vastly incomplete examination of the primate brains is an opportunity for progress.
This volume is a new, timely and fitting extension to the Handbook of Chemical Neuroanatomy, focussing on the neurochemical circuitry of the primate brain. The book will compliment the growing efforts to apply the analytical strategies of chemical neuroanatomy to the primate brain.The goal of this volume is to develop a broad-based coverage of human and non-human primate chemical neuroanatomic details together within a volume in which details on transmitters and systems can be appreciated.The eight comprehensive chapters that comprise this volume deal with large global concepts and datasets which not only create an initial coverage of the entire primate neuraxis, but also capture useful points of information on the chemical neuranatomy of the primate nervous system.An excellent, informative book, and a welcome addition to the sparse literature in this field.
This textbook provides a thorough and comprehensive overview of the human brain and spinal cord.
This long-awaited update of the classic, The Human Nervous System, stands as an impressive survey of our knowledge of the brain, spinal cord, and peripheral nervous system. The book has been completely redone and brought up-to-date. An impressive and respected cast of international authors have contributed 37 chapters on topics ranging from Brain Evolution, all phases of Brain Development, to all areas of the adult brain and peripheral pathways, along with careful descriptions of the spinal cord and peripheral nervous system, brainstem and cerebellum. The Human Nervous System, Second Edition will again serve as the gold standard, providing a one-stop source of up-to-date information about our knowledge of the human nervous system.This second edition of the standard reference on the human nervous system is extensively and completely revised and updated from the 1990 first edition. Written by the leading researchers, many chapters have been completely rewritten, new chapters have been added. A new section on Evolution and Development provides a broader perspective, and all chapters include references and perspectives to neurological disease.
The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. - Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations
The textbook builds a bridge between the "neurosciences" (theoretical and experimental neurobiology, neurology) and the "psychosciences" (psychology, psychiatry, psychotherapy) and aims to help provide the other disciplines with the most important and scientifically validated knowledge in an understandable form. The question of how mental experience and brain processes relate to each other has long been considered mysterious. In this book you will learn, based on the latest scientific findings, that the two areas form an indissoluble unity, even if we experience and study them differently. We present this unity in concrete terms in psychological-neurobiological theory and psychiatric-psychotherapeutic practice. We treat the principles of neurobiological excitation and information processing, the structure and function of the limbic system, the development of the personality and the interaction of genetic-epigenetic factors and prenatal and postnatal environmental influences, which may be favourable or unfavourable. On this basis, the exemplary presentation of important mental disorders such as addictive disorders, schizophrenic disorders, affective disorders and anxiety disorders takes place. Finally, following in the footsteps of the eminent psychotherapist Klaus Grawe, the concept of "neuropsychotherapy" is introduced and it is shown why psychotherapy and neurobiology belong together and can enrich each other. Our psychoneuroscientific approach paints a picture of man that is not based on opposites, but on an integration of psyche, brain, behavior and experience.
Synthesizing coverage of sensation and reward into a comprehensive systems overview, Neurobiology of Sensation and Reward presents a cutting-edge and multidisciplinary approach to the interplay of sensory and reward processing in the brain. While over the past 70 years these areas have drifted apart, this book makes a case for reuniting sensation a