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This book provides tabular and text data relating to normal and diseased tissue materials and materials used in medical devices. Comprehensive and practical for students, researchers, engineers, and practicing physicians who use implants, this book considers the materials aspects of both implantable materials and natural tissues and fluids. Examples of materials and topics covered include titanium, elastomers, degradable biomaterials, composites, scaffold materials for tissue engineering, dental implants, sterilization effects on material properties, metallic alloys, and much more. Each chapter author considers the intrinsic and interactive properties of biomaterials, as well as their appropriate applications and historical contexts. Now in an updated second edition, this book also contains two new chapters on the cornea and on vocal folds, as well as updated insights, data, and citations for several chapters.
PEEK biomaterials are currently used in thousands of spinal fusion patients around the world every year. Durability, biocompatibility and excellent resistance to aggressive sterilization procedures make PEEK a polymer of choice, replacing metal in orthopedic implants, from spinal implants and hip replacements to finger joints and dental implants. This Handbook brings together experts in many different facets related to PEEK clinical performance as well as in the areas of materials science, tribology, and biology to provide a complete reference for specialists in the field of plastics, biomaterials, medical device design and surgical applications. Steven Kurtz, author of the well respected UHMWPE Biomaterials Handbook and Director of the Implant Research Center at Drexel University, has developed a one-stop reference covering the processing and blending of PEEK, its properties and biotribology, and the expanding range of medical implants using PEEK: spinal implants, hip and knee replacement, etc. Covering materials science, tribology and applications Provides a complete reference for specialists in the field of plastics, biomaterials, biomedical engineering and medical device design and surgical applications
UHMWPE Biomaterials Handbook describes the science, development, properties and application of of ultra-high molecular weight polyethylene (UHMWPE) used in artificial joints. This material is currently used in 1.4 million patients around the world every year for use in the hip, knee, upper extremities, and spine. Since the publication of the 1st edition there have been major advances in the development and clinical adoption of highly crosslinked UHMWPE for hip and knee replacement. There has also been a major international effort to introduce Vitamin E stabilized UHMWPE for patients. The accumulated knowledge on these two classes of materials are a key feature of the 2nd edition, along with an additional 19 additional chapters providing coverage of the key engineering aspects (biomechanical and materials science) and clinical/biological performance of UHMWPE, providing a more complete reference for industrial and academic materials specialists, and for surgeons and clinicians who require an understanding of the biomaterials properties of UHMWPE to work successfully on patient applications. - The UHMWPE Handbook is the comprehensive reference for professionals, researchers, and clinicians working with biomaterials technologies for joint replacement - New to this edition: 19 new chapters keep readers up to date with this fast moving topic, including a new section on UHMWPE biomaterials; highly crosslinked UHMWPE for hip and knee replacement; Vitamin E stabilized UHMWPE for patients; clinical performance, tribology an biologic interaction of UHMWPE - State-of-the-art coverage of UHMWPE technology, orthopedic applications, biomaterial characterisation and engineering aspects from recognised leaders in the field
Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology.
The complexity of biological systems and the need to design and develop biomedical therapies poses major challenges to professionals in the biomedical disciplines. An Introduction to Biomaterials emphasizes applications of biomaterials for patient care. Containing chapters prepared by leading authorities on key biomaterial types, this book underscores the process of biomaterial design, development directed toward clinical application, and testing that leads to therapies for clinical targets. The authors provide a lucid perspective on the standards available and the logic behind the standards in which biomaterials address clinical needs. This volume includes chapters on consensus standards and regulatory approaches to testing paradigms, followed by an analysis of specific classes of biomaterials. The book closes with sections on clinical topics that integrate materials sciences and patient applications.
Most current applications of biomaterials involve structural functions, even in those organs and systems that are not primarily structural in their nature, or very simple chemical or electrical functions. Complex chemical functions, such as those of the liver, and complex electrical or electrochemical functions, such as those of the brain and sense organs, cannot be carried out by biomaterials at this time. With these basic concepts in mind, Biomaterials: Principles and Practices focuses on biomaterials consisting of different materials such as metallic, ceramic, polymeric, and composite. It highlights the impact of recent advances in the area of nano- and microtechnology on biomaterial design. Discusses the biocompatibility of metallic implants and corrosion in an in vivo environment Provides a general overview of the relatively bioinert, bioactive or surface-reactive ceramics, and biodegradable or resorbable bioceramics Reviews the basic chemical and physical properties of synthetic polymers, the sterilization of the polymeric biomaterials, the importance of the surface treatment for improving biocompatibility, and the application of the chemogradient surface for the study on cell-to-polymer interactions Covers the fundamentals of composite materials and their applications in biomaterials Highlights commercially significant and successful biomedical biodegradable polymers Examines failure modes of different types of implants based on material, location, and function in the body The book discusses the role of biomaterials as governed by the interaction between the material and the body, specifically, the effect of the body environment on the material and the effect of the material on the body.
Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.
This Handbook covers the fundamental aspects, experimental setup, synthesis, properties, and characterization of different nanocelluloses. It also explores the technology challenges of nanocelluloses and the emerging applications and the global markets of nanocelluloses-based systems. In particular, this book: · Covers the history of nanocelluloses, types and classifications, fabrication techniques, critical processing parameters, physical and chemical properties, surface functionalization, and other treatments to allow practical applications. · Covers all recent aspects of nanocelluloses technologies, from experimental set-up to industrial applications. · Includes new physical, chemical and biological techniques for nanocelluloses fabrication, in-depth treatment of their surface functionalization, and characterization. · Discusses the unique properties of nanocelluloses that can be obtained by modifying their diameter, morphology, composition and dispersion in other materials. · Discusses the properties and morphology of several kinds of dispersion in polymeric materials, such as micro/nanofiberlated cellulose, cellulose nanofibers, cellulose nanocrystals, amorphous cellulose nanoparticles, and hybrid cellulose nanomaterials. · Presents the different techniques for dispersion, and self-assembly of polymeric materials, critical parameters of synthesis, modelling and simulation, and characterization methods. · Highlights a wide range of emerging applications of nanocelluloses, e.g. drug delivery, tissue engineering, medical implants, medical diagnostics and therapy, biosensors, catalysis, energy harvesting, energy storage, water/waste treatment, papermaking, textiles, construction industry, automotive, aerospace and many more. · Provides an outlook on the opportunities and challenges for the fabrication and manufacturing of nanocelluloses in industry. · Provides an in-depth look at the nature of nanocelluloses in terms of their applicability for industrial uses. · Provides in-depth insight and review on most recent types of nanocelluloses-based systems of unique structures and compositions. · Highlights the challenges and interdisciplinary perspective of nanocelluloses-based systems in science, biology, engineering, medicine, and technology, incorporating both fundamentals and applications. - Demonstrates how cutting-edge developments in nanofibers translate into real-world innovations in a range of industry sectors. This Handbook is a valuable reference for materials scientists, biologists, physicians, chemical, biomedical, manufacturing and mechanical engineers working in R&D industry and academia, who want to learn more about how nanocelluloses-based systems are commercially applied.
Handbook of Ionic Substituted Hydroxyapatites provides scientists and researchers with comprehensive information on the synthesis processes of hydroxyapatite, also explaining the application of substituted hydroxyapatite. The book's content is very structured and explanatory, starting with a detailed overview of biological apatite in bones and teeth, as well as a presentation of the analytical tools for hydroxyapatite. Bioceramics and the relative modern and emerging processing techniques are covered, as is 3-D printing, which has gained increasing importance within biomedical materials and in the use of hydroxyapatite in tissue engineering. Finally, the advantages and disadvantages of using ionic substitutions in clinical application are presented. Students and researchers in disciplines, such as Material Science, Ceramics, and Bioengineering will find this book to be very helpful in their work. It will also be a valuable resource for practitioners and surgeons in orthopedics, perio/implantology and maxillo-facial disciplines, and professionals working in R&D in ceramics and pharmaceuticals. - Provides responses to the lack of scientific information about hydroxyapatites for biomedical applications - Solves researchers' issues regarding phase changes with respect to substituted ions and how these substitutions can alter/improve the properties of stoichiometric hydroxyapatite - Explains modern clinical applications and the effects of apatites within biomedical applications - Includes both the advantages and disadvantages of using ionic substitutions in clinical application
This volume focuses on a variety of production and processing aspects of the latest biomaterials. It discusses how scaffolds are used in tissue engineering and describes common implant materials, such as hard tissue, blood contacting, and soft tissue. The book also examines the important role nanotechnology plays in the preparation of drugs, protein delivery, tissue engineering, cardiovascular biomaterials, hard tissue replacements, biosensors, and bio-MEMS. With contributions from renowned international experts and extensive reference lists in each chapter, this book provides detailed, practical information to produce biomaterials and employ them in biomedicine.