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Discover twenty transformational habits of some of the most successful leaders, CEOs, and entrepreneurs today!
In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.
The all-new Hummer H3 will reach market in early 2005, just as this book chronicling its development is published. The H3 will offer traditional Hummer off-road durability and stump-pulling power in a smaller, more-affordable SUV-styled package. Interest in the new model is very high and the automotive website "edmunds.com" reported, ". . . the smaller and cheaper H3 is likely to become the most popular Hummer ever."
The patterns we cultivate shape the person we each become. Be Humble. Stay Hungry. Always Hustle. These powerful words describe the leader who is willing to work hard, get it done, and make sure it’s not about him or her; the leader who knows that influence is about developing the right habits for success. Brad Lomenick, former president of Catalyst, shares his hard-earned insights from more than two decades of work alongside thought-leaders such as Jim Collins and Malcom Gladwell, Fortune 500 CEOs and start-up entrepreneurs. Operating within the framework of three core character qualities – humble, hungry, hustle – Lomenick identifies 20 essential leadership habits that help readers embody those qualities, including: Staying open and sharing the real you with others Owning your convictions and sticking to your principles Developing an appetite for what’s next Pursuing innovation by staying current, creative, and engaged Demanding excellence by setting standards that scare you Fostering collaboration with colleagues and competitors Offering practical steps to embrace these habits, H3 Leadership provides a simple but effective guide on how to lead well in whatever capacity the reader may be in.
Graph theory is an area in discrete mathematics which studies configurations (called graphs) involving a set of vertices interconnected by edges. This book is intended as a general introduction to graph theory and, in particular, as a resource book for junior college students and teachers reading and teaching the subject at H3 Level in the new Singapore mathematics curriculum for junior college.The book builds on the verity that graph theory at this level is a subject that lends itself well to the development of mathematical reasoning and proof.