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Intended for postgraduate and professional researchers in biochemistry, biomedical sciences and cell biology, this text offers a guide to the extracellular matrix and adhesion proteins.
A compendium of the proteins found in the extracellular matrix and those known to be involved in cell-cell contact and adhesion. Organized alphabetically, it summarizes the essential features of these proteins, giving key references and drawing together information from wide-ranging sources.
Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.
The biology of the 1980s and 1990s may well come to be remembered as the era of discovery of new proteins. Recent advances in molecular biology, genetics, and protein purification have conspired to accelerate the rate at which cellular proteins and their amino acid sequences are being identified. Now that the floodgate of discovery has been opened wide, the amount of new information on cellular proteins is exceeding most scientists' capacity for assimilation. At the same time, however, it has become imperative for research workers to expand their knowledge base because interactions between previously unconnected sets of proteins are being uncovered at such a rapid pace. These considerations have led Thomas E. Kreis and Ronald D. Vale to compile both the Guidebook to Cytoskeletal and Motor Proteins and the Guidebook to the Extracellular Matrix and Adhesion Proteins. Both books are distinguished by numerous outstanding features, including: concise compendiums of molecular information, consolidation of information from widely scattered sources, key references, clearly designed pages with many high-quality illustrations, and the first compilations of concise descriptions of the structure, function, and distribution of the proteins covered. Guidebook to Cytoskeletal and Motor Proteins covers actin and actin binding proteins, tubulin and associated proteins, the intermediate filaments, motor proteins, cytoskeletal anchor proteins, organelle membrane associated structural proteins, and other proteins. Introductory chapters provide overviews for each class of protein. Biological and structural attributes of about 200 individual proteins, or groups of closely related proteins, are concisely described by investigators who participated in their discovery or characterization. In addition, information regarding purification methods, assays of activity, and available reagents, together with a list key review and research articles, are included. Over 240 authors contributed to the entries. Guidebook to the Extracellular Matrix and Adhesion Proteins provides a concise compendium of the proteins found in the extracellular matrix and those known to be involved in cell-cell contact and adhesion. Organized alphabetically, it summarizes the key characteristics of these proteins and includes the same features--such as introductory chapters and contributions from the field's leading experts--that make its companion volume so essential. Designed to explain the each protein in an accessible manner, the book is also referenced for in-depth reading and provides excellent overviews.
The precise shape of a protein is a crucial factor in its function. How do proteins become folded into the right conformation? Molecular chaperones and protein folding catalysts bind to developing polypeptides in the cytoplasm and ensure correct folding and transport. This Guidebook catalogues the latest information on nearly 200 of these molecules, including the important class of heat shock proteins; each entry is written by leading researchers in the field.
"Provides an in-depth review of current print and electronic tools for research in numerous disciplines of biology, including dictionaries and encyclopedias, method guides, handbooks, on-line directories, and periodicals. Directs readers to an associated Web page that maintains the URLs and annotations of all major Inernet resources discussed in th
Essential Developmental Biology is a comprehensive, richly illustrated introduction to all aspects of developmental biology. Written in a clear and accessible style, the third edition of this popular textbook has been expanded and updated In addition, an accompanying website provides instructional materials for both student and lecturer use, including animated developmental processes, a photo gallery of selected model organisms, and all artwork in downloadable format. With an emphasis throughout on the evidence underpinning the main conclusions, this book is an essential text for both introductory and more advanced courses in developmental biology. Shortlisted for the Society of Biology Book Awards 2013 in the Undergraduate Textbook category. Reviews of the Second Edition: "The second edition is a must have for anyone interested in development biology. New findings in hot fields such as stem cells, regeneration, and aging should make it attractive to a wide readership. Overall, the book is concise, well structured, and illustrated. I can highly recommend it." —Peter Gruss, Max Planck Society "I have always found Jonathan Slack's writing thoughtful, provocative, and engaging, and simply fun to read. This effort is no exception. Every student of developmental biology should experience his holistic yet analytical view of the subject." —Margaret Saha, College of William & Mary
Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike. - Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves - Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems - Full-color presentation throughout
The number of cytokines and related growth factors has increased dramatically in recent years to several dozen. This text provides a succinct reference manual for all known cytokines, growth factors, interleukins and lymphokines as well as their receptors.